Biogenesis Evolution Homeostasis

Locker, A.

doi:10.1007/978-3-642-95235-7

Cited by 13 publications

(4 citation statements)

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“…It has often been suggested that polyphosphates were involved in prebiotic evolution (Kulaev 1979;Kulaev et al 2004;Griffith et al 1977; Keefe and Miller 1995;Fernández-Garcia et al 2017;Prieur 2009), where a strong case advocating this molecular family has been made (Gabel 1973(Gabel , 1977. There is, however, no general acceptance for the above rolls of condensed phosphates in prebiotic biochemistry.…”

Section: Chemistrymentioning

confidence: 99%

“…Wyatt and West 2014 Biogenesis Brown and Kornberg 2004;Fernández-Garcia et al 2017;Gabel 1977;Griffith et al 1977;Keefe and Miller 1995;Kulaev et al 2004;Kulaev and Vagabov 1983;Lazcano and Miller 1996;Locker 1973;Oró 1994;Westheimer 1987Archaen, Eoarchaen Karki et al 2017Lazcano and Miller 1996;Maciá 2005;Spang et al 2017; chains with a degree of condensation up to 10 were termed oligophosphatases and were contrasted with the polyphosphate depolymerases and metaphosphatases (cyclophosphatases) (Mattenheimer 1956a, b). The determination of large ring metaphosphates among the products of long chain polyphosphate hydrolysis was never pursued because of the lack of analytical methods capable of adequately distinguishing among the larger polyand meta-phosphate reaction products.…”

Section: Chain Polyphosphate and Cyclic Metaphosphate Hydrolysis And mentioning

confidence: 99%

“…Within the context of a symposium on the origins of life entitled Biogenesis Evolution Homeostasis (Locker 1973), Gabel presented his hypothesis of "structuralization", which involves condensed phosphate as an energy source and as an organizational scaffold (Gabel 1973). In this context "excitability" is defined as the property of an organized group of particles to transfer environmental information along its parts resulting in the maintenance of its structural integrity (Gabel 1965).…”

Section: Gabel's Hypothesismentioning

confidence: 99%

“…It was suggested by Gabel, while discussing the role of circular nucleic acids in evolution, that a more likely primordial condensing agent, namely inorganic circular polyphosphate, could have served as the template and the condensing agent for cyclic polynucleotides, because thermally produced polyphosphate mixtures are known to contain a broad range of cyclic (metaphosphate) rings (Locker 1973).…”

Section: Gabel's Hypothesismentioning

confidence: 99%

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Did Cyclic Metaphosphates Have a Role in the Origin of Life?

Glonek

2021

Orig Life Evol Biosph

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How life began still eludes science life, the initial progenote in the context presented herein, being a chemical aggregate of primordial inorganic and organic molecules capable of self-replication and evolution into ever increasingly complex forms and functions.Presented is a hypothesis that a mineral scaffold generated by geological processes and containing polymerized phosphate units was present in primordial seas that provided the initiating factor responsible for the sequestration and organization of primordial life’s constituents. Unlike previous hypotheses proposing phosphates as the essential initiating factor, the key phosphate described here is not a polynucleotide or just any condensed phosphate but a large (in the range of at least 1 kilo-phosphate subunits), water soluble, cyclic metaphosphate, which is a closed loop chain of polymerized inorganic phosphate residues containing only phosphate middle groups. The chain forms an intrinsic 4-phosphate helix analogous to its structure in Na Kurrol’s salt, and as with DNA, very large metaphosphates may fold into hairpin structures. Using a Holliday-junction-like scrambling mechanism, also analogous to DNA, rings may be manipulated (increased, decreased, exchanged) easily with little to no need for additional energy, the reaction being essentially an isomerization.A literature review is presented describing findings that support the above hypothesis. Reviewed is condensed phosphate inorganic chemistry including its geological origins, biological occurrence, enzymes and their genetics through eukaryotes, polyphosphate functions, circular polynucleotides and the role of the Holliday junction, previous biogenesis hypotheses, and an Eoarchean Era timeline.

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Section: Chemistrymentioning

confidence: 99%

Section: Chain Polyphosphate and Cyclic Metaphosphate Hydrolysis And mentioning

confidence: 99%

Section: Gabel's Hypothesismentioning

confidence: 99%

Section: Gabel's Hypothesismentioning

confidence: 99%

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Did Cyclic Metaphosphates Have a Role in the Origin of Life?

Glonek

2021

Orig Life Evol Biosph

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Overlapping functional systems: A theory for vertebrate central nervous system function in terms of informal systems analysis

Legare

1980

Syst. Res.

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An holistic theory of the functional organization of the central nervous system, a system at the level of the organ, in vertebrate organisms is presented as an alternative to localization of function by using two sets of complementary rules for systems designation derived from systems theory. These rules reveal three types of systems according to levels of operation and the origins of goals. These are: (1) the teleogenic or primary systems (reproductive, food-water intake-use, thermoregulative, immune, oxygen intake-use); (2) the teleozetic or subsystems (internal sensory and motor, external motor, external sensory); (3) the teleonomic systems or echelons (field, local circuit, basic functional unit, basic excitation unit). The systems, subsystems, and echelons are discussed with regard to their hierarchical relationships, the nature of their goals, and the supporting experimental evidence. The theory is discussed as an explicit statement of multileveled relationships for the analysis of the vertebrate CNS and, therefore, as presenting a paradigm for, or a way of thinking about, local and global brain theories, brain dysfunction, and brain evolution.

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Literatur

Schwefel¹

1977

Numerische Optimierung Von Computer-Modellen Mittels Der Evolutionsstrategie

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Biogenesis Evolution Homeostasis

Cited by 13 publications

References 0 publications

Did Cyclic Metaphosphates Have a Role in the Origin of Life?

Did Cyclic Metaphosphates Have a Role in the Origin of Life?

Overlapping functional systems: A theory for vertebrate central nervous system function in terms of informal systems analysis

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