Biogenesis of endosome-derived transport carriers

Richard, J.; Harrison, Megan S.; Burd, Christopher G.

doi:10.1007/s00018-015-1935-x

Cited by 49 publications

(53 citation statements)

References 148 publications

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“…The early endosome is a central hub in membrane trafficking, particularly in neurons (Kennedy and Ehlers, 2006), and cellular mechanisms carefully regulate the balance of transport in and out of this organelle (Chi et al, 2015; Pfeffer, 2013). Enlarged endosomes represent an imbalance in endosomal trafficking and this phenotype is therefore one, although not the only, manifestation of endosomal traffic jams.…”

Section: Endosomal Traffic Jams In Alzheimer’s Diseasementioning

confidence: 99%

Endosomal Traffic Jams Represent a Pathogenic Hub and Therapeutic Target in Alzheimer’s Disease

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Simoes-Spassov

Mayeux

et al. 2017

Trends in Neurosciences

129

111

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While clues have existed that endosomal trafficking is associated with Alzheimer’s disease (AD), whether it plays a central role in the disease and if so how has remained unknown. Here we rely on recent genetic and cellular findings to construct a model proposing that traffic jams in the early endosome can act as an upstream pathogenic hub in AD. We also rely on an independent series of findings to suggest how the traffic jams can act as a unified mediator of downstream pathophysiology. The model predicts, therefore, that interventions designed to unjam the endosome carry high therapeutic promise.

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Section: Endosomal Traffic Jams In Alzheimer’s Diseasementioning

confidence: 99%

Endosomal Traffic Jams Represent a Pathogenic Hub and Therapeutic Target in Alzheimer’s Disease

Small

Simoes-Spassov

Mayeux

et al. 2017

Trends in Neurosciences

129

111

View full text Add to dashboard Cite

show abstract

“…trans‐Golgi network and/or cell surface) for reuse. This process is orchestrated by a number of endosomal sorting machineries which play a crucial role in the maintenance of cellular homeostasis (Chi et al ., ). However, the molecular nature of these endosomal sorting machineries is not clearly understood, especially not in filamentous fungi.…”

Section: Introductionmentioning

confidence: 97%

The endosomal recycling of FgSnc1 by FgSnx41–FgSnx4 heterodimer is essential for polarized growth and pathogenicity in Fusarium graminearum

et al. 2018

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Endosomal sorting machineries regulate the transport of their cargoes among intracellular compartments. However, the molecular nature of such intracellular trafficking processes in pathogenic fungal development and pathogenicity remains unclear. Here, we dissect the roles and molecular mechanisms of two sorting nexin proteins and their cargoes in endosomal recycling in Fusarium graminearum using high-resolution microscopy and high-throughput co-immunoprecipitation strategies. We show that the sorting nexins, FgSnx41 and FgSnx4, interact with each other and assemble into a functionally interdependent heterodimer through their respective BAR domains. Further analyses demonstrate that the dimer localizes to the early endosomal membrane and coordinates endosomal sorting. The small GTPase FgRab5 regulates the correct localization of FgSnx41-FgSnx4 and is consequently required for its trafficking function. The protein FgSnc1 is a cargo of FgSnx41-FgSnx4 and regulates the fusion of secreted vesicles with the fungal growing apex and plasma membrane. In the absence of FgSnx41 or FgSnx4, FgSnc1 is mis-sorted and degraded in the vacuole, and null deletion of either component causes defects in the fungal polarized growth and virulence. Overall, for the first time, our results reveal the mechanism of FgSnc1 endosomal recycling by FgSnx41-FgSnx4 heterodimer which is essential for polarized growth and pathogenicity in F. graminearum.

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“…14 and 15). It is the spatial and temporal coordination of the interactions between the retromer and retromer interactome that enables it to coordinate multiple endosome-derived trafficking pathways (16).…”

mentioning

confidence: 99%

Parkinson Disease-linked Vps35 R524W Mutation Impairs the Endosomal Association of Retromer and Induces α-Synuclein Aggregation

Follett

Bugarčić

Yang

et al. 2016

Journal of Biological Chemistry

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Endosomal sorting is a highly orchestrated cellular process. Retromer is a heterotrimeric complex that associates with endosomal membranes and facilitates the retrograde sorting of multiple receptors, including the cation-independent mannose 6-phosphate receptor for lysosomal enzymes. The cycling of retromer on and off the endosomal membrane is regulated by a network of retromer-interacting proteins. Here, we find that Parkinson disease-associated Vps35 variant, R524W, but not P316S, is a loss-of-function mutation as marked by a reduced association with this regulatory network and dysregulation of endosomal receptor sorting. Expression of Vps35 R524W-containing retromer results in the accumulation of intracellular ␣-synuclein-positive aggregates, a hallmark of Parkinson disease. Overall, the Vps35 R524W-containing retromer has a decreased endosomal association, which can be partially rescued by R55, a small molecule previously shown to stabilize the retromer complex, supporting the potential for future targeting of the retromer complex in the treatment of Parkinson disease.

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Biogenesis of endosome-derived transport carriers

Cited by 49 publications

References 148 publications

Endosomal Traffic Jams Represent a Pathogenic Hub and Therapeutic Target in Alzheimer’s Disease

Endosomal Traffic Jams Represent a Pathogenic Hub and Therapeutic Target in Alzheimer’s Disease

The endosomal recycling of FgSnc1 by FgSnx41–FgSnx4 heterodimer is essential for polarized growth and pathogenicity in Fusarium graminearum

Parkinson Disease-linked Vps35 R524W Mutation Impairs the Endosomal Association of Retromer and Induces α-Synuclein Aggregation

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