Biogenesis of Peroxisomes

Peroxisomes: simple in function but complex in maintenance

“…The implications are numerous, but the evidence is scarce. The experiments carried out in Y. lipolytica 28 are the only real challenge to the model originally proposed by Lazarow and Fujiki in 1985 that states that peroxisomes multiply by growth and division of preexisting organelles 29 . The experiments by the Rachubinski group showed that Pex2p and Pex16p are N-glycosylated and can be followed in a pulse-chase experiment from ER to peroxisomes, and it will be important to confirm these results using other organisms.…”

Tetratricopeptide repeat domain of Yarrowia lipolytica Pex5p is essential for recognition of the type 1 peroxisomal targeting signal but does not confer full biological activity on Pex5p

“…Peroxisomal proteins are encoded by nuclear genes and are synthesized on cytosolic polysomes before being imported into peroxisomes posttranslationally [1]. So far, three peroxisomal targeting signals (PTSs) have been identified (reviewed in [2,3]).…”

Hansenula polymorpha: An attractive model organism for molecular studies of peroxisome biogenesis and function

“…Despite their simple morphology, the organelles show a great diversity in enzyme repertoires and, as a consequence, may be involved in a variety of metabolic processes [2][3][4]. These functions are partly inducible in nature and may also vary with the developmental stage and/or growth conditions of the related organism.…”