Biogenesis of selenium nanoparticles and their anti-leukemia activity

Anu, Kasi; Devanesan, Sandhanasamy; Prasanth, Ramesh; AlSalhi, Mohamad S.; Ajithkumar, S.; Ganesan, Singaravelu

doi:10.1016/j.jksus.2020.04.018

Cited by 64 publications

(46 citation statements)

References 39 publications

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“…In vitro cytotoxicity. Figure 6A-E displays the in-vitro cytotoxic potentiality of SeNPs at different concentrations (0, 5,10,15,20,25,30,35,40,45, 50 µg/mL) and its effects on proliferation of HBL-100 cells (Fig. 6A,C) and MDA-MB-231 cells (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…The larval toxicity was analyzed www.nature.com/scientificreports/ as per the WHO standard guidelines (WHO, 1996) with slight modifications. Accordingly, 25 healthy 1st to 4th instar larvae were introduced separately into a 250 mL bioassay container, loaded with 199 mL tap water and SeNPs at various concentrations (10,20,30,40 and 50 mg/mL). Larval tissues from control and treated Ae.…”

Section: Tetrazoliummentioning

confidence: 99%

“…To deal with this cataclysm researchers recommend advanced green nanotechnology technics to acquire solutions for vector disease 7 . Selenium is one of the critical trace elements required for normal functioning in the living cells of mammals and higher animals [8][9][10] . Nowadays, selenium nanoparticles (SeNPs) are accepted by many enthusiastic researchers and recommended for use in various scientific disciplines due to their less toxicity and high stability 11 .…”

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confidence: 99%

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Green synthesis of selenium nanoparticles mediated from Ceropegia bulbosa Roxb extract and its cytotoxicity, antimicrobial, mosquitocidal and photocatalytic activities

Vetrivel

Durairaj

Kalaimurugan

et al. 2021

Sci Rep

181

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The present study is to design an eco-friendly mode to rapidly synthesize selenium nanoparticles (SeNPs) through Ceropegia bulbosa tuber’s aqueous extracts and confirming SeNPs synthesis by UV–Vis spectroscopy, FT-IR, XRD, FE-SEM-EDS mapping, HR-TEM, DLS and zeta potential analysis. In addition, to assess the anti-cancer efficacy of the SeNPs against the cultured MDA-MB-231, as studies have shown SeNPs biosynthesis downregulates the cancer cells when compared to normal HBL100 cell lines. The study observed the IC50 value of SeNPs against MDA-MB-231 cells was 34 µg/mL for 48 h. Furthermore, the SeNPs promotes growth inhibitory effects of certain clinical pathogens such as Bacillus subtilis and Escherichia coli. Apart, from this the SeNPs has shown larvicidal activity after 24 h exposure in Aedes albopitus mosquito’s larvae with a maximum of 250 g/mL mortality concentration. This is confirmed by the histopathology results taken at the 4th larval stage. The histopathological studies revealed intense deterioration in the hindgut, epithelial cells, mid gut and cortex region of the larvae. Finally, tried to investigate the photocatalytic activity of SeNPs against the toxic dye, methylene blue using halogen lamp and obtained 96% degradation results. Withal computational study SeNPs was shown to exhibit consistent stability towards breast cancer protein BRCA2. Overall, our findings suggest SeNPs as a potent disruptive agent for MDA-MB-231 cells, few pathogens, mosquito larvae and boosts the photocatalytic dye degradation.

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Section: Resultsmentioning

confidence: 99%

Section: Tetrazoliummentioning

confidence: 99%

mentioning

confidence: 99%

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Green synthesis of selenium nanoparticles mediated from Ceropegia bulbosa Roxb extract and its cytotoxicity, antimicrobial, mosquitocidal and photocatalytic activities

Vetrivel

Durairaj

Kalaimurugan

et al. 2021

Sci Rep

181

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“…Hu et al demonstrated the bioavailability of SeNPs in roots and shoots where they could be biotransformed into organic Se compounds, selenite and selenate to generate Se-biofortified plants [236]. However, the in vitro synthesis using plant extracts is better since it eliminates the lengthy process of cultivation, but still allows for screening the experimental parameters, such as the biomass choice, extraction process and amount, the pH, and temperature [237].…”

Section: Plant-mediated Synthesis Of Metalloid Nanoparticlesmentioning

confidence: 99%

Green Synthesis of Selenium and Tellurium Nanoparticles: Current Trends, Biological Properties and Biomedical Applications

Zambonino

Quizhpe

Jaramillo

et al. 2021

IJMS

112

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The synthesis and assembly of nanoparticles using green technology has been an excellent option in nanotechnology because they are easy to implement, cost-efficient, eco-friendly, risk-free, and amenable to scaling up. They also do not require sophisticated equipment nor well-trained professionals. Bionanotechnology involves various biological systems as suitable nanofactories, including biomolecules, bacteria, fungi, yeasts, and plants. Biologically inspired nanomaterial fabrication approaches have shown great potential to interconnect microbial or plant extract biotechnology and nanotechnology. The present article extensively reviews the eco-friendly production of metalloid nanoparticles, namely made of selenium (SeNPs) and tellurium (TeNPs), using various microorganisms, such as bacteria and fungi, and plants’ extracts. It also discusses the methodologies followed by materials scientists and highlights the impact of the experimental sets on the outcomes and shed light on the underlying mechanisms. Moreover, it features the unique properties displayed by these biogenic nanoparticles for a large range of emerging applications in medicine, agriculture, bioengineering, and bioremediation.

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“…Biomolecules present in the extracts of plants, such as polysaccharides, phenolic compounds, flavonoids, tannins, saponins, amino acids, enzymes, proteins, and sugars, are known to be potential reducing agents of selenium and have medicinal importance. Nanoparticles tend to agglomerate, thus, a stabilizer is often used to inhibit their over-growth by coating with a single layer of polymer or surfactant which reduces the interactions between nanoparticles [22,30,53,59]. Some authors reported that the used plant extracts contained phytochemicals that exhibited stabilizing properties [24,25,28,32,57].…”

Section: Biosynthesismentioning

confidence: 99%

Biosynthesis of selenium nanoparticles using plant extracts

2021

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Selenium nanoparticles (SeNPs) have the potential to be used for various applications. Therefore, they have attracted more attention in recent years and several synthesis methods have been exploited. Green synthesis using plant extracts has gained popularity because it requires non-toxic solvents and moderate temperatures. Furthermore, it is environmentally friendly and uses a reducing agent that is easily accessible and biodegradable. In this review, we present recent reports concerning the capability of different plant materials for the biosynthesis of selenium nanoparticles. The synthesis conditions (temperature, time, selenium precursor, and extract concentration) are discussed in combination with the characteristics of the obtained product (composition, size, shape, stability). The application of synthesized selenium nanoparticles was briefly presented. Graphic abstract

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Biogenesis of selenium nanoparticles and their anti-leukemia activity

Cited by 64 publications

References 39 publications

Green synthesis of selenium nanoparticles mediated from Ceropegia bulbosa Roxb extract and its cytotoxicity, antimicrobial, mosquitocidal and photocatalytic activities

Green synthesis of selenium nanoparticles mediated from Ceropegia bulbosa Roxb extract and its cytotoxicity, antimicrobial, mosquitocidal and photocatalytic activities

Green Synthesis of Selenium and Tellurium Nanoparticles: Current Trends, Biological Properties and Biomedical Applications

Biosynthesis of selenium nanoparticles using plant extracts

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