Biogenic amine metabolism in juvenile neurocardiogenic syncope with dysautonomia

Butler, Ian J.; Lankford, Jeremy; Hashmi, S. Shahrukh; Numan, Mohammed T

doi:10.1002/acn3.49

Cited by 6 publications

(4 citation statements)

References 22 publications

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“…Vitamin D plays a crucial role in autonomic balance and may act as a central neuroactive substance. In a case report of a patient diagnosed with postural orthostatic tachycardia syndrome by tilt table studies, 1,25-dihydroxyvitamin D 1 25(OH) 2D] 1 25(OH) D3, calcitriol] – the main biologically active form of Vitamin D was found to be below normal. Supplementation with calcitriol resulted in improvement of orthostatic intolerance and palpitations.…”

Section: Itamin D For a mentioning

confidence: 95%

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Is Vitamin D deficiency implicated in autonomic dysfunction?

Wadhwania

2017

J Pediatr Neurosci

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Dysautonomia, dysfunction of the autonomic nervous system, presents with heterogeneous clinical features from an imbalanced regulation of the sympathetic and parasympathetic nervous systems. Low Vitamin D levels can explain the heterogeneous clinical features of migraine headaches, cardiac and gastrointestinal dysfunction, and oxidative stress evident in dysautonomia patients. The role of Vitamin D in modulating pain sensitivity has been recently established. However, there is a lack of research and understanding regarding the association between Vitamin D deficiency and autonomic dysfunction. Vitamin D is a neuroactive hormone that modulates autonomic balance, regulating the sympathetic and parasympathetic nervous systems, and has multisystem benefits. The following review explores the literature and addresses the relationship between Vitamin D deficiency and autonomic dysfunction. Overall, this literature review implicates Vitamin D deficiency in autonomic dysfunction and elucidates the potential therapeutic role of Vitamin D in autonomic disorders. PubMed search was performed for English articles from 1996 to 2016. Following keywords: Vitamin D, autonomic dysfunction and orthostatic hypotension, Vitamin D receptor, migraine and traumatic brain injury, Vitamin D, cardiac and gastrointestinal disease, Vitamin D, glutathione, oxidative stress, and serotonin were included. Only articles reporting primary data relevant to the above question were included in the study.

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Section: Itamin D For a mentioning

confidence: 95%

“…Oxidative stress with increased pro-inflammatory markers and low levels of cerebrospinal fluid serotonin and dopamine metabolites- 5HIAA, and HVA are evident in a subset of patients with juvenile neurocardiogenic syncope with dysautonomia based on abnormal tilt table test. [ 1 2 ]…”

Section: Introductionmentioning

confidence: 99%

Is Vitamin D deficiency implicated in autonomic dysfunction?

Wadhwania

2017

J Pediatr Neurosci

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“…Despite an extensive evidence base of Vitamin D's deficiency and insufficiency studies in connection to numerous children's diseases, many aspects of this connection are left unclear and disputable. In the recent years, there are many reports on Vitamin D deficiency's implication in children's syncope pathogenesis [11][12][13]. In 2018, the European Society of Cardiology (ESC) published the clinical Guidelines for the diagnosis and management of syncope, in which all the nontraumatic transient losses of consciousness were classified according to four principal groups: syncope (reflex, orthostatic hypotension, cardiogenic), epileptic seizures, psychogenic (psychogenic pseudosyncope (PPS), psychogenic non-epileptic seizures (PNES) and some rare diseases Лекції, огляди / Lectures, Reviews [14].…”

Section: Introductionmentioning

confidence: 99%

Вітамін-D-Статус У Пацієнтів Із Транзиторними Втратами Свідомості Нетравматичного Генезу (Огляд Літератури)

Kovalchuk¹,

Boyarchuk²

2021

PJS

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The article presents an analysis of the recent scientific findings on vitamin D status in patients with different etiopathogene tic varieties of nontraumatic transient loss of consciousness. The results of recent researches suggest that vitamin D may play an indirect and, in some cases, direct role in the pathogenesis of nontraumatic transient loss of consciousness. Data on the causeeffect relationship between a low vitamin D status and syncope are mixed, controversial and ambiguous, which is largely due to the use of different doses of vitamin D, its initial concentration, duration of therapy, genetic diffe rences in the vitamin D receptors, different age groups, physical parameters of the surveyed, medications, peculiarities of nutrition with special supplements, differences in physical activity, peculiarities of the climate and season, and others. Until now there is no convincing evidence of the benefits of using vitamin D in the treatment and prevention of syncope. Most studies are observational and relate mainly to adult populations. Therefore, randomized controlled studies focused on children may be a promising field of research.

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“…It presents with multiple symptoms including constipation, insomnia, dizziness, blurred vision, cold and clammy palms and soles, abnormal blood pressure, headaches, lightheadedness with orthostatic intolerance and palpitations. Autonomic dysfunction has also been associated with increased pain sensitivity as in reflex sympathetic dystrophy with pain out of proportion to the cause [3][4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Autonomic Dysfunction in Epileptic Patients

Özer¹

2018

J Clin Exp Invest

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To investigate autonomic symptoms in different types of epilepsy in comparison to control subjects. To observe whether autonomic symptoms cause possible morbidity and mortality and to make a preliminary remedy Patients and Methods: A retrospective chart review was conducted for 28 patients diagnosed with epilepsy including 18 patients with complex partial epilepsy (CPE) and 10 patients with primary generalized epilepsy (PJE). Their autonomic symptoms were assessed using the COMPASS-31 questionnaire in comparison to a control group of 18 subjects. Results: No statistically significant differences were found in autonomic dysfunction symptoms between patients with CPE and patients with PJE. However, constipation and insomnia which autonomic symptoms were statistically significantly more common in epileptic patients compared to the control group. Conclusions: It is important to recognize and watch out for symptoms of autonomic dysfunction in patients with epilepsy. We believe that awareness for these symptoms is essential both to reduce associated disability and develop specific treatment strategies and to predict sudden unexpected death in epileptic patients.

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Biogenic amine metabolism in juvenile neurocardiogenic syncope with dysautonomia

Cited by 6 publications

References 22 publications

Is Vitamin D deficiency implicated in autonomic dysfunction?

Is Vitamin D deficiency implicated in autonomic dysfunction?

Вітамін-D-Статус У Пацієнтів Із Транзиторними Втратами Свідомості Нетравматичного Генезу (Огляд Літератури)

Autonomic Dysfunction in Epileptic Patients

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