“…Senthilkumar et al discovered the role of Laurusnobilis plant extricated SeNPs as an effective inhibitory agent for Mycobacterium smegmatus with the ZOI of 15 mm, this extracted SeNPs is shown to hinder Listeria monocytogenes , B. megaterium and S. aureus growth. The discoveries of this investigation are similar to those previously expressed 23 . Figure 10 ( A ) The antibacterial activity of SeNPs on different pathogenic bacteria ( B. subtilis and E.coli ) at different concentration (25, 50, 75, and 100 µg) and control antibiotic methicillin (The zone of inhibition values are expressed as mean ± SD and analyzed by one-way variance (ANOVA).…”
Section: Resultssupporting
confidence: 88%
“…Protein-protein interaction study for the selection of BRCA2 for SeNPs complexity. www.nature.com/scientificreports/ www.nature.com/scientificreports/ The ionic interaction between the negatively charged SeNPs and the penetrated gram positive B. subtilis or gram negative E. coli leads the SeNPs to cause cell damage by destrupting the cell wall 23,24 . The morphological changes of untreated and SeNPs treated B. Subtilis and E. coli were observed with FE-SEM analysis (Fig.…”
Section: In-silico Analysis For Carrierness Of Senp In Breast Cancer mentioning
The present study is to design an eco-friendly mode to rapidly synthesize selenium nanoparticles (SeNPs) through Ceropegia bulbosa tuber’s aqueous extracts and confirming SeNPs synthesis by UV–Vis spectroscopy, FT-IR, XRD, FE-SEM-EDS mapping, HR-TEM, DLS and zeta potential analysis. In addition, to assess the anti-cancer efficacy of the SeNPs against the cultured MDA-MB-231, as studies have shown SeNPs biosynthesis downregulates the cancer cells when compared to normal HBL100 cell lines. The study observed the IC50 value of SeNPs against MDA-MB-231 cells was 34 µg/mL for 48 h. Furthermore, the SeNPs promotes growth inhibitory effects of certain clinical pathogens such as Bacillus subtilis and Escherichia coli. Apart, from this the SeNPs has shown larvicidal activity after 24 h exposure in Aedes albopitus mosquito’s larvae with a maximum of 250 g/mL mortality concentration. This is confirmed by the histopathology results taken at the 4th larval stage. The histopathological studies revealed intense deterioration in the hindgut, epithelial cells, mid gut and cortex region of the larvae. Finally, tried to investigate the photocatalytic activity of SeNPs against the toxic dye, methylene blue using halogen lamp and obtained 96% degradation results. Withal computational study SeNPs was shown to exhibit consistent stability towards breast cancer protein BRCA2. Overall, our findings suggest SeNPs as a potent disruptive agent for MDA-MB-231 cells, few pathogens, mosquito larvae and boosts the photocatalytic dye degradation.
“…Senthilkumar et al discovered the role of Laurusnobilis plant extricated SeNPs as an effective inhibitory agent for Mycobacterium smegmatus with the ZOI of 15 mm, this extracted SeNPs is shown to hinder Listeria monocytogenes , B. megaterium and S. aureus growth. The discoveries of this investigation are similar to those previously expressed 23 . Figure 10 ( A ) The antibacterial activity of SeNPs on different pathogenic bacteria ( B. subtilis and E.coli ) at different concentration (25, 50, 75, and 100 µg) and control antibiotic methicillin (The zone of inhibition values are expressed as mean ± SD and analyzed by one-way variance (ANOVA).…”
Section: Resultssupporting
confidence: 88%
“…Protein-protein interaction study for the selection of BRCA2 for SeNPs complexity. www.nature.com/scientificreports/ www.nature.com/scientificreports/ The ionic interaction between the negatively charged SeNPs and the penetrated gram positive B. subtilis or gram negative E. coli leads the SeNPs to cause cell damage by destrupting the cell wall 23,24 . The morphological changes of untreated and SeNPs treated B. Subtilis and E. coli were observed with FE-SEM analysis (Fig.…”
Section: In-silico Analysis For Carrierness Of Senp In Breast Cancer mentioning
The present study is to design an eco-friendly mode to rapidly synthesize selenium nanoparticles (SeNPs) through Ceropegia bulbosa tuber’s aqueous extracts and confirming SeNPs synthesis by UV–Vis spectroscopy, FT-IR, XRD, FE-SEM-EDS mapping, HR-TEM, DLS and zeta potential analysis. In addition, to assess the anti-cancer efficacy of the SeNPs against the cultured MDA-MB-231, as studies have shown SeNPs biosynthesis downregulates the cancer cells when compared to normal HBL100 cell lines. The study observed the IC50 value of SeNPs against MDA-MB-231 cells was 34 µg/mL for 48 h. Furthermore, the SeNPs promotes growth inhibitory effects of certain clinical pathogens such as Bacillus subtilis and Escherichia coli. Apart, from this the SeNPs has shown larvicidal activity after 24 h exposure in Aedes albopitus mosquito’s larvae with a maximum of 250 g/mL mortality concentration. This is confirmed by the histopathology results taken at the 4th larval stage. The histopathological studies revealed intense deterioration in the hindgut, epithelial cells, mid gut and cortex region of the larvae. Finally, tried to investigate the photocatalytic activity of SeNPs against the toxic dye, methylene blue using halogen lamp and obtained 96% degradation results. Withal computational study SeNPs was shown to exhibit consistent stability towards breast cancer protein BRCA2. Overall, our findings suggest SeNPs as a potent disruptive agent for MDA-MB-231 cells, few pathogens, mosquito larvae and boosts the photocatalytic dye degradation.
“…The details are summarized in Table 1, and parts of TEM or SEM images of CeO 2 with different morphologies are shown in Figure 2. Sphericalshaped CeO 2 NPs showed antibacterial activity against Gramnegative bacteria Escherichia coli (E. coli) and Pseudomonas aeruginosa (P. aeruginosa) and less or no antibacterial activity against Gram-positive bacteria Staphylococcus aureus (S. aureus) (Ravishankar et al, 2015;Selvaraj et al, 2015;Surendra and Roopan, 2016;Senthilkumar et al, 2019), because of the direct contact onto the membrane surface of E. coli that blocks the synthesis of the cell wall and membrane and disturbs other cellular processes (Senthilkumar et al, 2019). Similarly, it was found that the CeO 2 NPs showed superior activity against Gramnegative E. coli than Gram-positive Bacillus subtilis (B. subtilis), which has a slight reduction in survival (Patil et al, 2016).…”
Section: Cerium Oxide For Antibacterial Applicationmentioning
Infectious diseases caused by bacteria remain a serious and global problem in human health. Herein, the discovery and application of antibiotics, which has attracted much attention in the past years, has helped to cure numerous infectious diseases and made huge contributions in the biomedical field. However, the widespread use of the broad-spectrum antibiotics has led to serious drug resistance for many human bacterial pathogens. In particular, bacterial drug resistance decreases therapeutic effects and leads to high mortality. Inspiringly, the introduction of nanomaterials in the biomedical field makes it possible to overcome the difficulty in bacterial drug resistance attributed to their unique antibacterial mechanism. Recently, a variety of metal-and metal oxide-based nanomaterials have been fully integrated in antibacterial applications and achieved excellent performances. Among them, cerium-and cerium oxide-based nanomaterials have received much attention worldwide. Remarkably, cerium oxide nanoparticles with lower toxicity act as effective antibacterial agents owing to their unique functional mechanism against pathogens through the reversible conversion of oxidation state between Ce(III) and Ce(IV). This article provides an overview of the state-of-the-art design and antibacterial applications of cerium-and cerium oxidebased materials. The first part discusses the underlying antibacterial mechanisms for cerium-and cerium oxide-based materials currently applied in biomedicine. The second part focuses on various antibacterial-related materials and their applications. In addition, the existing problems and future perspectives of the cerium-and cerium oxide-based materials make up the third part of this review. This paper could provide the possible mechanisms for antibacterial activities, various designs of cerium-and cerium oxide-based materials, and related antibacterial properties.
“…However, among the various biological systems for nanoparticle synthesis, plant mediated synthesis has captured major attention due to its role in rapid synthesis of nanoparticles, low cost, easy availability, safe handling and presence of broad range of biomolecules like tannins, flavanoids, alkaloids, phenols and hence this gives it the edge as the chassis of choice for an environment friendly and sustained application [11]. Nanoparticles have been synthesized using many different plant sources, to mention a few, silver nanoparticles using Cordia dichotoma fruit [12], iron oxide nanoparticles using Cynometra ramiflora leaf [13], copper nanoparticles using Solanum lycopersicum leaf [14], zinc oxide nanoparticles using Phyllanthus emblica leaf [15], gold nanoparticles using Artocarpus Lakoocha fruit, cerium oxide nanoparticles using Sida acuta leaf [16], titanium nanoparticles using Vigna Radiata seeds [17].…”
An environment friendly green synthesis of iron oxide nanoparticles using the seed coat extract of B.flabellifer was investigated. The nanoparticles were characterized using XRD, UV–vis spectroscopy, FTIR, TGA, SEM and EDS. The x-ray diffraction spectrum showed the formation of crystalline inverse spinel magnetite nanoparticles with crystallite size of 35 nm and the UV–vis absorption recorded characteristic peak at 352 nm for iron oxide nanoparticles. The surface functionalization of the nanoparticles was confirmed from the various functional group peaks present in the FTIR spectrum and the thermal decomposition of the synthesized nanoparticles from TGA. The morphological study using SEM showed the formation of hexagonal shaped, well dispersed nanoparticles. The cytocompatibilty of the iron oxide nanoparticles was studied using MTT assay and haemolytic analysis. The antimicrobial activity of the nanoparticles against E. coli, S. aureus, B.subtilis, Shigella, A.niger and Candida albicans were measured and the nanoparticles showed significant activity against all the microorganisms which increased with increase in the nanoparticle concentration. The free radical scavenging activity of the nanoparticles against DPPH, Hydrogen peroxide and hydroxyl radical was performed which showed efficient antioxidant activity.
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