Biogenic production of seleno-amino acids and seleno-nanoparticles by Saccharomyces boulardii

González-Salitre, Lourdes; Castañeda‐Ovando, Araceli; Basilio-Cortés, Ulin Antobelli; García-Contreras, Adelfa del Carmen; Serrano, Gabriela M Rodríguez; Cardelle‐Cobas, Alejandra; Román‐Gutiérrez, Alma Delia; González-Olivares, Luis Guillermo

doi:10.1016/j.fbio.2023.102552

Cited by 11 publications

(5 citation statements)

References 37 publications

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“…boulardii resulted in a diameter of approximately 235 nm; González-Salitre et al reported that BioSeNPs produced by S. boulardii had diameters ranging from 100 to 200 nm, both of which exhibited a spherical morphology and nonuniform distribution. EDS analysis also confirmed the presence of BioSeNPs, with a relative selenium content of 8.32% in the BWT group and 17.53% in the BMS group (Figures E,F and S1,S2).…”

Section: Resultsmentioning

confidence: 99%

“…In contrast, the BioSeNPs generated using the BWT predominantly showed a size distribution between 100 and 200 nm, with an average particle size of approximately 134.59 nm (Figure 3B−D). Based on the work of Brammer et al, the green synthesis of BioSeNPs produced by S. boulardii resulted in a diameter of approximately 235 nm; 20 Gonzaĺez-Salitre et al reported that BioSeNPs produced by S. boulardii had diameters ranging from 100 to 200 nm, 21 both of which exhibited a spherical morphology and nonuniform distribution. EDS analysis also confirmed the presence of BioSeNPs, with a relative selenium content of 8.32% in the BWT group and 17.53% in the BMS group (Figures 3E,F and S1,S2).…”

Section: Properties Of the Biosenps Under Optimizedmentioning

confidence: 99%

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Superoxide Dismutase Catalyzed Size-Adjustable Selenium Nanoparticles in Saccharomyces boulardii

Yang,

Song,

Gao

et al. 2024

J. Agric. Food Chem.

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Selenium nanoparticles (SeNPs) are important and safe food and feed additives that can be used for dietary supplementation. In this study, a mutagenic strain of Saccharomyces boulardii was employed to obtain biologically synthesized SeNPs (BioSeNPs) with the desired particle size by controlling the dosage and duration of sodium selenite addition, and the average particle size achieved was 55.8 nm with protease A encapsulation. Transcriptomic analysis revealed that increased expression of superoxide dismutase 1 (SOD1) in the mutant strain effectively promoted the synthesis of BioSeNPs and the formation of smaller nanoparticles. Under sodium selenite stress, the mutant strain exhibited significantly increased expression of glutathione peroxidase 2 (GPx2), which was significantly greater in the mutant strain than in the wild type, facilitating the synthesis of glutathione selenol and providing abundant substrates for the production of BioSeNPs. Furthermore, based on the experimental results and transcriptomic analysis of relevant genes such as sod1, gpx2, the thioredoxin reductase 1 gene (trr1) and the thioredoxin reductase 2 gene (trr2), a yeast model for the size-controlled synthesis of BioSeNPs was constructed. This study provides an important theoretical and practical foundation for the green synthesis of controllable-sized BioSeNPs or other metal nanoparticles with potential applications in the fields of food, feed, and biomedicine.

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Section: Resultsmentioning

confidence: 99%

Section: Properties Of the Biosenps Under Optimizedmentioning

confidence: 99%

Superoxide Dismutase Catalyzed Size-Adjustable Selenium Nanoparticles in Saccharomyces boulardii

Yang,

Song,

Gao

et al. 2024

J. Agric. Food Chem.

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“…Se is an indispensible trace element (50-200 g/day) to human health, more than 40 diseases are highly related to Se deficiency, such as Se supply can maintain glucose and lipid homeostasis in type 2 diabetes patients, its deficiency or excess led to βcell dysfunction [144]; Se deficiency lead to increased vascular endothelial permeability and vascular tissue damage by decreasing SelO expression [200]. Se-rich soy peptides can prevent liver damage caused by heat stress and exercise fatigue by increased glutathione content and glutathioneperoxidase peroxidase activity in rat liver, and protected rat liver by regulating NF-κB/IκB pathway and preventing the release of interleukin-1, interleukin-6 and tumor necrosis factor α; anticancer SeNPs enhanced the autophagy ability of cancer cells by activating the ROS mediated JNK pathway and inhibiting the PI3K/Akt/mTOR pathway [144]; The fermented beer enriched with organic Se (0.378mg / kg) produce for functional foods [201]. Ca may alter the composition of bile by preventing the reabsorption of secondary bile acids in the colon, thus reducing the deoxycholate and cholesterol content of the bile [149].…”

Section: Minerals Mechanismmentioning

confidence: 99%

Actional Mechanism of Functional Ingredients in Beer and Barley for Human Health

Zeng,

Ahmed,

et al. 2024

Preprint

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Nutrition therapy is the best solution to human chronic diseases, especially beer and barley which play an important role in human health and civilization. We demonstrated the actional mechanism of functional ingredients in beer and barley to combat chronic diseases, based on PubMed, google, CNKI, and ISI Web of Science databases from 1997 to 2024. Beer is rich in functional ingredients that is a complex of barley malt and hops; the health effect of beer against 26 chronic diseases is highly similar to that of barley, due to molecular mechanism of polyphenols (phenolic acids, flavonoids), melatonin, minerals, bitter acids, vitamins, and peptides. The ancient German Beer Purity Law provides much scientific basis today, especially indirectly supporting the human one cell disease theory. Low purine beer can be produced by enzymatic and biological degradation and adsorption of purines as well as dandelion addition. Functional beer with low purine and high active ingredients made from Beer Purity and barley malt as well as functional foods addition will be the key and important development direction, such as ginger beer and ginseng beer, especially coix-lily beer at the ancestors ca. 9000 years ago. This review paper not only reveals the actional mechanism of beer overcoming human chronic diseases, but also provides scientific basis for the development of functional beer for the prevention and treatment of human chronic diseases.

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“…For example, Xu et al [ 46 ] synthesized SeNPs by fermentation under anaerobic conditions using the probiotic Lactobacillus casei ATCC 393 as the starting strain and Na 2 SeO 3 as the selenium source ( Figure 5 ). In another study, Gonzalez-Salitre et al [ 48 ] investigated the progress of bioproduction of Se nanoparticles by probiotic yeast due to their ease of culture, lack of toxicity and pathogenicity. Fan et al [ 11 ] realized the green synthesis of SeNPs by using rose eggplant leaf extract as the reducing agent.…”

Section: Synthesis Strategy Of Selenium Nanoparticlesmentioning

confidence: 99%

The Developments of Surface-Functionalized Selenium Nanoparticles and Their Applications in Brain Diseases Therapy

Wang

Han

et al. 2023

Biomimetics

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Selenium (Se) and its organic and inorganic compounds in dietary supplements have been found to possess excellent pharmacodynamics and biological responses. However, Se in bulk form generally exhibits low bioavailability and high toxicity. To address these concerns, nanoscale selenium (SeNPs) with different forms, such as nanowires, nanorods, and nanotubes, have been synthesized, which have become increasingly popular in biomedical applications owing to their high bioavailability and bioactivity, and are widely used in oxidative stress-induced cancers, diabetes, and other diseases. However, pure SeNPs still encounter problems when applied in disease therapy because of their poor stability. The surface functionalization strategy has become increasingly popular as it sheds light to overcome these limitations in biomedical applications and further improve the biological activity of SeNPs. This review summarizes synthesis methods and surface functionalization strategies employed for the preparation of SeNPs and highlights their applications in treating brain diseases.

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Biogenic production of seleno-amino acids and seleno-nanoparticles by Saccharomyces boulardii

Cited by 11 publications

References 37 publications

Superoxide Dismutase Catalyzed Size-Adjustable Selenium Nanoparticles in Saccharomyces boulardii

Superoxide Dismutase Catalyzed Size-Adjustable Selenium Nanoparticles in Saccharomyces boulardii

Actional Mechanism of Functional Ingredients in Beer and Barley for Human Health

The Developments of Surface-Functionalized Selenium Nanoparticles and Their Applications in Brain Diseases Therapy

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