Biogenic selenium nanoparticles synthesized by Lactobacillus casei ATCC 393 alleviate diquat-induced intestinal barrier dysfunction in C57BL/6 mice through their antioxidant activity

Abstract

Biogenic SeNPs synthesized by Lactobacillus casei ATCC 393 reversed diquat-induced oxidative damage to the epithelium by activating the Nrf2 signaling pathway.

Effects of Selenium- and Zinc-Enriched Lactobacillus plantarum SeZi on Antioxidant Capacities and Gut Microbiome in an ICR Mouse Model

“…In this study, we focused on the changes in the gut microbial composition as well as functional metabolism associated with Se/Zn uptake and utilization. Interestingly, Se/Zn supplementation greatly induced the enrichment of specific genus, Lactococcus (belonging to LAB), which confirmed the previous reports regarding in vitro tolerance of LAB to selenium [ 46 , 47 ]. However, this indigenously enriched LAB by inorganic Se/Zn supplement showed significantly different patterns in the microbial selenocompounds metabolism compared with Se/Zn-bioaccumulated L. plantarum SeZi strain.…”

“…The accumulation of selenium in bacteria is processed by extracellular binding via active groups in the cell-membrane conjunction or intracellular binding via ion transportation on the membrane [ 45 ]. Many Lactobacillus strains are well-known to accumulate and biotransform toxic selenite into non-toxic seleno-amino acids (i.e., selenocysteine and selenomethionine) and selenoprotein [ 46 , 47 ] The utilization of Se-enriched Lactobacillus possesses unique advantages, including low toxicity, low cost production and additional probiotic effects.…”

“…When selenium is incorporated into the selenoenzymes (i.e., GSH-Px), it enhances the antioxidant activities by suppressing the nuclear factor-kappa B (NF-κB) signal pathway [ 53 ]. Most selenoproteins take part in the defense against oxidative stress, protecting tissues and cells from oxidative damages [ 47 ]. Although the SZ group was administered with inorganic forms of Se/Zn, the SZ + Lp group was administered with bio-accumulated Se/Zn in bacteria.…”

Using Green Biosynthesized Lycopene-Coated Selenium Nanoparticles to Rescue Renal Damage in Glycerol-Induced Acute Kidney Injury in Rats

“…In particular, biogenic SeNPs synthesized by green nanotechnology represent promising and safe selenium supplements with low toxicity, high bioavailability, low cost, and eco-friendly processing. 41 In this regard, our study herein illustrated the potential of SeNPs synthesized using LYC as a therapeutic approach to alleviate AKI-related tissue damage in terms of oxidative stress, inflammation, apoptosis, and necroptosis.…”

Biogenic selenium nanoparticles produced by Lactobacillus casei ATCC 393 inhibit colon cancer cell growth in vitro and in vivo

“…Our observation, that the probiotic strain L. casei ATCC 393 is able to synthesize nano-Se, has been further confirmed by three recently published papers. 31,38,39 Most of the microorganisms that are able to produce nano-Se, synthesize nanoparticles of a spherical shape. 40 Their size varies significantly because it depends on the different experimental parameters employed (microbial strain, Se source, incubation period).…”