Biogenic silver nanoparticles for cancer treatment: An experimental report

Jeyaraj, Murugaraj; Sathishkumar, Gnanasekar; Sivanandhan, Ganeshan; MubarakAli, D.; Rajesh, Manoharan; Renganathan, Arun; Kapildev, Gnanajothi; Manickavasagam, Markandan; Thajuddin, Nooruddin; Premkumar, Kumpati; Ganapathi, A.

doi:10.1016/j.colsurfb.2013.01.027

Cited by 417 publications

(220 citation statements)

References 24 publications

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“…Therefore, MCF-7 is potentially a very suitable epithelial cell model for the hazard identification of nanomaterials. AgNP toxicity to MCF-7 cells has been reported to be size (Liu et al, 2010b) and dose dependent (Jeyaraj et al, 2013) after 24 h exposure.…”

Section: Introductionmentioning

confidence: 99%

Different responses of Caco-2 and MCF-7 cells to silver nanoparticles are based on highly similar mechanisms of action

et al. 2016

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The mode of action of silver nanoparticles (AgNPs) is suggested to be exerted through both Ag + and AgNP dependent mechanisms. Ingestion is one of the major NP exposure routes, and potential effects are often studied using Caco-2 cells, a well-established model for the gut epithelium. MCF-7 cells are epithelial breast cancer cells with extensive well-characterized toxicogenomics profiles. In the present study, we aimed to gain a deeper understanding of the cellular molecular responses in Caco-2 and MCF-7 cells after AgNP exposure in order to evaluate whether epithelial cells derived from different tissues demonstrated similar responses. These insights could possibly reduce the size of cell panels for NP hazard identification screening purposes. AgNPs of 20, 30, 60, and 110 nm, and AgNO 3 were exposed for 6 h and 24 h. AgNPs were shown to be taken up and dissolve intracellularly. Compared with MCF-7 cells, Caco-2 cells showed a higher sensitivity to AgNPs, slower gene expression kinetics and absence of NP size-dependent responses. However, on a molecular level, no significant differences were observed between the two cell types. Transcriptomic analysis showed that Ag(NP) exposure caused (oxidative) stress responses, possibly leading to cell death in both cell lines. There was no indication for effects specifically induced by AgNPs. Responses to AgNPs appeared to be induced by silver ions released from the AgNPs. In conclusion, differences in mRNA responses to AgNPs between Caco-2 and MCF-7 cells were mainly related to timing and magnitude, but not to a different underlying mechanism.

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Section: Introductionmentioning

confidence: 99%

Different responses of Caco-2 and MCF-7 cells to silver nanoparticles are based on highly similar mechanisms of action

et al. 2016

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“…Among the various nanoparticles available, silver nanoparticles are gaining more importance due to their diversified biological properties and potential applications. Silver has been used since ancient times for the treatment of wounds and inflammation and nanoparticles of silver have been developed which have potent antiinflammatory [6] and antioxidant activities [7].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of In-vitro Anti-Inflammatory Activity of Silver Nanoparticles Synthesised using Piper Nigrum Extract

S¹

2015

J Nanomed Nanotechnol

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Introduction: Nanotechnology has emerged as an exciting approach in the drug development process and among the various nanoparticles, silver nanoparticles have been explored for its variety of medical applications. Phyto assisted synthesis of silver nanoparticles is an eco-friendly and cost effective method for the development of silver nanoparticles with additional properties conferred by the capping phytochemicals.

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“…This attachment of drug is done via functional groups or drug can be loaded inside the CNTs. Binding of the drug to the outer surface of the CNTs can be done through covalent or non-covalent bonding such as hydrophobic, π-π interaction, electrostatic interactions or Van Der Walls forces [19]. …”

Section: C) Cnts In Drug Deliverymentioning

confidence: 99%

“…The plant has been widely used in conventional medicines as well as in advanced medicines for the treatment of diseases viz. tumour and liver disorders [19]. S. Grandiflora (L.) leaf extract was made by mixing 20 g of leaf powder in 200 ml distilled water.…”

Section: (Iv) Silver Nanoparticlesmentioning

confidence: 99%

Revolutionary Therapies and Manipulation of Nanoparticles to Cure Cancer

2016

J Bioelectron Nanotechnol

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Cancer is a malignant neoplastic disease that proliferates throughout the whole body rapidly causing the body to deteriorate and eventually kills the human because of its fatality. Remarkably large number of types of cancers have been discovered by to-day which are named according to their causes and the site of tumour. Cancer spreads quickly across the body. The 1.5 million lives lost per year represent 25% of the estimated 6 million premature cancer deaths that will occur by 2025, and the 6 million figure is itself based on population projections of current numbers and aging. Various therapies have been invented in order to reduce the proliferation pace. Use of nanoparticles such as Au, Ag, Zn nanoparticles in the treatment of cancer into various renowned therapies have been elucidated in the review article. Along with these, the review article has detailed description about two specific therapies namely, Magnetic Hyperthermia and Magnetic Chemotherapy.

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Biogenic silver nanoparticles for cancer treatment: An experimental report

Cited by 417 publications

References 24 publications

Different responses of Caco-2 and MCF-7 cells to silver nanoparticles are based on highly similar mechanisms of action

Different responses of Caco-2 and MCF-7 cells to silver nanoparticles are based on highly similar mechanisms of action

Evaluation of In-vitro Anti-Inflammatory Activity of Silver Nanoparticles Synthesised using Piper Nigrum Extract

Revolutionary Therapies and Manipulation of Nanoparticles to Cure Cancer

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