Biogenic Synthesis of Gold Nanoparticles Using Dual Extract of Tulsi– Vinca for Breast Cancer Tumor Regression in Mice

Abstract

Aim: This work aims to synthesize the gold nanoparticles (GNPs) using a dual extract of tulsi and Vinca (T+V-Gold) for breast cancer tumor regression. Methods: The GNPs were synthesized and characterized for their microscopic, spectroscopic and crystalline properties. Further, the GNPs were investigated for in vitro and in vivo studies for the treatment of the 4T1-induced triple-negative breast cancer murine model. Results: The GNPs for 4T1 tumor-challenged mice resulted in delayed tumor development and lower tumor burden, with T+V-Gold demonstrating the highest prevention of tumor spread. The antitumor effect of T+V-Gold is highly significant in the glutathione family antioxidants glutathione S-transferase and glutathione in tumor tissue samples. Conclusion: The bioefficacy and anticancer outcomes of T+V-Gold nanoformulation can be used as therapeutic agents and drug-delivery vehicles.

Biogenic synthesis of dual-emission chlorophyll-rich carbon quantum dots for detection of toxic heavy metal ions – Hg(ii) and As(iii) in water and mouse fibroblast cell line NIH-3T3

“…9(c)). 71,72 Almost negligible hemolysis was detected in all experimental groups compared to that of the positive control (Triton-X) proving their biocompatibility with red blood cells at both time intervals. Nanoparticles such as gold nanoparticles, silver nanoparticles, and CdTe nanoparticles have been widely used in biosensing assays, but their toxicity has been a concern.…”