Biogenic zinc oxide nanoparticles as an antibacterial, antifungal, and photocatalytic tool mediated via leaves of Girardinia diversifolia

Negi, Aayasha; Gangwar, Reena; Vishwakarma, Rahul Kumar; Negi, Devendra Singh

doi:10.1007/s41204-022-00216-6

Cited by 13 publications

(2 citation statements)

References 23 publications

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“…The antifungal efficiency of the biogenic ZnO NPs (100 µg/disc) against C. glabrata was twofold higher than that of the control. A prior study demonstrated the antifungal efficacy of biogenic ZnO NPs (1 mg/mL) synthesized using aqueous leaf extract of Girardinia diversifolia against C. albicans with an inhibitory zone diameter of 20.23 ± 0.65 mm [74]. Overall, the antifungal effectiveness of the biogenic ZnO NPs was significantly higher than that reported in a previous study, where the used concentration was 1 mg/mL, which is 20-fold higher than that used in the current study (50 µg/L), with inhibition zone diameters of 20.23 ± 0.65 and 21.36 ± 0.19 mm against C. albicans strain.…”

Section: Screening Of Anticandidal Efficiency Of the Biosynthesized Z...mentioning

confidence: 99%

Facile Green Synthesis of Zinc Oxide Nanoparticles with Potential Synergistic Activity with Common Antifungal Agents against Multidrug-Resistant Candidal Strains

et al. 2022

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The high incidence of fungal resistance to antifungal drugs represents a global concern, contributing to high levels of morbidity and mortality, especially among immunocompromised patients. Moreover, conventional antifungal medications have poor therapeutic outcomes, as well as possible toxicities resulting from long-term administration. Accordingly, the aim of the present study was to investigate the antifungal effectiveness of biogenic zinc oxide nanoparticles (ZnO NPs) against multidrug-resistant candidal strains. Biogenic ZnO NPs were characterized using physicochemical methods, such as UV-vis spectroscopy, transmission electron microscopy (TEM), energy-dispersive X ray (EDX) spectroscopy, FTIR (Fourier transform infrared) spectroscopy and X-ray powder diffraction (XRD) analysis. UV spectral analysis revealed the formation of two absorption peaks at 367 and 506 nm, which preliminarily indicated the successful synthesis of ZnO NPs, whereas TEM analysis showed that ZnO NPs exhibited an average particle size of 22.84 nm. The EDX spectrum confirmed the successful synthesis of ZnO nanoparticles free of impurities. The FTIR spectrum of the biosynthesized ZnO NPs showed different absorption peaks at 3427.99, 1707.86, 1621.50, 1424.16, 1325.22, 1224.67, 1178.22, 1067.69, 861.22, 752.97 and 574.11 cm−1, corresponding to various functional groups. The average zeta potential value of the ZnO NPs was −7.45 mV. XRD analysis revealed the presence of six diffraction peaks at 2θ = 31.94, 34.66, 36.42, 56.42, 69.54 and 76.94°. The biogenic ZnO NPs (100µg/disk) exhibited potent antifungal activity against C. albicans, C. glabrata and C. tropicalis strains, with suppressive zone diameters of 24.18 ± 0.32, 20.17 ± 0.56 and 26.35 ± 0.16 mm, respectively. The minimal inhibitory concentration (MIC) of ZnO NPs against C. tropicalis strain was found to be 10 μg/mL, whereas the minimal fungicidal concentration (MFC) was found to be 20 μg/mL. Moreover, ZnO NPs revealed a potential synergistic efficiency with fluconazole, nystatin and clotrimazole antifungal drugs against C. albicans strain, whereas terbinafine, nystatin and itraconazole antifungal drugs showed a potential synergism with ZnO NPs against C. glabrata as a multidrug-resistant strain. In conclusion, pomegranate peel extract mediated green synthesis of ZnO NPs with potential physicochemical features and antimicrobial activity. The biosynthesized ZnO NPs could be utilized for formulation of novel drug combinations to boost the antifungal efficiency of commonly used antifungal agents.

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Section: Screening Of Anticandidal Efficiency Of the Biosynthesized Z...mentioning

confidence: 99%

Facile Green Synthesis of Zinc Oxide Nanoparticles with Potential Synergistic Activity with Common Antifungal Agents against Multidrug-Resistant Candidal Strains

et al. 2022

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“…In addition to being safe, affordable, environmentally friendly, non-hazardous, and biocompatible, this usage of plant extract offers the potential for large-scale production [ 37 ]. A prior report indicated the anticandidal efficiency of ZnO-NPs fabricated utilizing Girardinia diversifolia extract against C. albicans strains with a relative suppressive zone diameter of 20.23 ± 0.65 mm [ 38 ]. Moreover, the biogenic ZnO-NPs synthesized using Carissa opaca extract revealed antifungal efficiency against C. albicans strains with a relative inhibitory zone diameter of 16.0 ± 1 mm [ 39 ].…”

Section: Introductionmentioning

confidence: 99%

Synergistic Anticandidal Effectiveness of Greenly Synthesized Zinc Oxide Nanoparticles with Antifungal Agents against Nosocomial Candidal Pathogens

Yassin,

Al-Otibi,

Al-Askar

et al. 2023

Microorganisms

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The high prevalence of fungal resistance to antifungal drugs necessitates finding new antifungal combinations to boost the antifungal bioactivity of these agents. Hence, the aim of the present investigation was to greenly synthesize zinc oxide nanoparticles (ZnO-NPs) using an aqueous leaf extract of Salvia officinalis and investigate their antifungal activity and synergistic efficiency with common antifungal agents. The biofabricated ZnO-NPs were characterized to detect their physicochemical properties. A disk diffusion assay was employed to investigate the antifungal effectiveness of the greenly synthesized ZnO-NPs and evaluate their synergistic patterns with common antifungal agents. The Candida tropicalis strain was detected to be the most susceptible strain to ZnO-NPs at both tested concentrations of 50 and 100 µg/disk, demonstrating relative suppressive zones of 19.68 ± 0.32 and 23.17 ± 0.45 mm, respectively. The minimum inhibitory concentration (MIC) of ZnO-NPs against the C. tropicalis strain was 40 µg/mL, whereas the minimum fungicidal concentration (MFC) was found to be 80 µg/mL. The highest synergistic efficiency of the biogenic ZnO-NPs with terbinafine antifungal agent was detected against the C. glabrata strain, whereas the highest synergistic efficiency was detected with fluconazole against the C. albicans strain, demonstrating relative increases in fold of inhibition area (IFA) values of 6.82 and 1.63, respectively. Moreover, potential synergistic efficiency was detected with the nystatin antifungal agent against the C. tropicalis strain with a relative IFA value of 1.06. The scanning electron microscopy (SEM) analysis affirmed the morphological deformations of candidal cells treated with the biosynthesized ZnO-NPs as the formation of abnormal infoldings of the cell wall and membranes and also the formation of pores in the cell wall and membranes, which might lead to the leakage of intracellular constituents. In conclusion, the potential synergistic efficiency of the biogenic ZnO-NPs with terbinafine, nystatin, and fluconazole against the tested candidal strains highlights the potential application of these combinations in formulating novel antifungal agents of high antimicrobial efficiency. The biogenic ZnO nanoparticles and antifungal drugs exhibit powerful synergistic efficiency, which highlights their prospective use in the formulation of efficient antimicrobial medications, including mouthwash, ointments, lotions, and creams for effective candidiasis treatment.

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Antimicrobial activity of the biologically synthesized zinc oxide nanoparticles against important rice pathogens

Cheema

Abbas

Noman

et al. 2022

Physiol Mol Biol Plants

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Biogenic zinc oxide nanoparticles as an antibacterial, antifungal, and photocatalytic tool mediated via leaves of Girardinia diversifolia

Cited by 13 publications

References 23 publications

Facile Green Synthesis of Zinc Oxide Nanoparticles with Potential Synergistic Activity with Common Antifungal Agents against Multidrug-Resistant Candidal Strains

Facile Green Synthesis of Zinc Oxide Nanoparticles with Potential Synergistic Activity with Common Antifungal Agents against Multidrug-Resistant Candidal Strains

Synergistic Anticandidal Effectiveness of Greenly Synthesized Zinc Oxide Nanoparticles with Antifungal Agents against Nosocomial Candidal Pathogens

Antimicrobial activity of the biologically synthesized zinc oxide nanoparticles against important rice pathogens

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