Biogeographical characteristics of Schistosoma mansoni endemic areas in Ethiopia: a systematic review and meta analysis

Ponpetch, Keerati; Erko, Berhanu; Bekana, Teshome; Richards, Lindsay; Liang, Song

doi:10.1186/s40249-021-00864-x

Cited by 12 publications

(13 citation statements)

References 53 publications

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“…It is interesting to note that the model performance was also influenced by elevation, which is the most influential variable in the WC-based model and the second most in the SDSM-based model. This result confirmed that elevation was an important indicator for spatial monitoring of snail-borne diseases because certain ranges of elevation favor some snail species [ 15 ]. Consequently, elevation can be used to help identify the populations most vulnerable to schistosomiasis [ 55 ].…”

Section: Discussionsupporting

confidence: 63%

“…For example, a study in the United States showed a potentially suitable habitat for three different fishes [ 53 ], and Dal Maso and Montecchio [ 54 ] studied the geographical distribution of ash dieback disease among trees in Europe. Results from our ensemble models showed that the majority of suitable areas for S. mansoni in Ethiopia were located in the West Montane and Rift Valley ecozones [ 15 ]. The findings largely agreed with reports of the high rate of infection in villages around Lake Tana and in rift valley areas near Lake Ziway and Lake Abaya reported three decades ago [ 55 ].…”

Section: Discussionmentioning

confidence: 99%

“…A GIS database of historical S. mansoni infection surveys was developed from a systematic review and described in a separate paper [ 15 ]. In brief, a systematic review was conducted to assess S. mansoni infections (e.g., prevalence of infection, infection intensity, and distribution) in Ethiopia.…”

Section: Methodsmentioning

confidence: 99%

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Environmental Drivers and Potential Distribution of Schistosoma mansoni Endemic Areas in Ethiopia

et al. 2021

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In Ethiopia, human schistosomiasis is caused by two species of schistosome, Schistosoma mansoni and S. haematobium, with the former being dominant in the country, causing infections of more than 5 million people and more than 37 million at risk of infection. What is more, new transmission foci for S. mansoni have been reported over the past years in the country, raising concerns over the potential impacts of environmental changes (e.g., climate change) on the disease spread. Knowledge on the distribution of schistosomiasis endemic areas and associated drivers is much needed for surveillance and control programs in the country. Here we report a study that aims to examine environmental determinants underlying the distribution and suitability of S. mansoni endemic areas at the national scale of Ethiopia. The study identified that, among five physical environmental factors examined, soil property, elevation, and climatic factors (e.g., precipitation and temperature) are key factors associated with the distribution of S. mansoni endemic areas. The model predicted that the suitable areas for schistosomiasis transmission are largely distributed in northern, central, and western parts of the country, suggesting a potentially wide distribution of S. mansoni endemic areas. The findings of this study are potentially instrumental to inform public health surveillance, intervention, and future research on schistosomiasis in Ethiopia. The modeling approaches employed in this study may be extended to other schistosomiasis endemic regions and to other vector-borne diseases.

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Section: Discussionsupporting

confidence: 63%

Section: Discussionmentioning

confidence: 99%

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Environmental Drivers and Potential Distribution of Schistosoma mansoni Endemic Areas in Ethiopia

et al. 2021

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“…The pooled prevalence of S. mansoni infection among children was highest in the SNNPR 41.49% (95%CI: 19.52-63.46) followed by the Amhara region 41.11%, (95%CI: 30.41-51.80), the Tigray region 31.4%, (95%CI: 11.72-51.09), and the Oromia regional state 28.98%, (95%CI: 18.85-39.10). This variation might be due to the different environmental and ecological variations, the difference in population density, and variability in efficacy of praziquantel [81][82][83]. The difference in environmental sanitation, personal hygiene, altitude differences, sanitation of streams/rivers, ponds, epidemiology of the snail vector, habit of open defecation, utilization of night soil as a fertilized might also contribute to the difference [84].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Schistosoma mansoni infection among children in Ethiopia: a systematic review and meta-analysis

Bisetegn

Eshetu

Erkihun

2021

Trop Dis Travel Med Vaccines

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Background Schistosomiasis is a neglected tropical disease caused by mainly Schistosoma mansoni and Schistosoma hematobium. The disease is very common in Africa including Ethiopia. Schistosoma mansoni is a major public health problem in Ethiopia especially among children. This review is aimed to indicate the prevalence of Schistosoma mansoni among children at the national and regional levels. Methods and material The PRISMA guidelines were followed. An electronic search of PubMed, Google Scholar, Web of Science, Scopus, MEDLINE, and Google search were carried out using key terms. Articles published from the proceeding of professional associations such as the Ethiopian medical laboratory association, the Ethiopian public health association, and annual national research conferences were also searched to find additional eligible studies. Data were extracted independently by two investigators, and cross-checked by a third reviewer. The quality of included studies was assessed using JBI quality assessment criteria. Data were extracted using Microsoft excel and finally analyzed using STATA version 12. The pooled prevalence was done using a random-effects model. Result Overall 49 studies involving 20,493 children (10,572 male and 9, 921 females) were included in this meta-analysis. The pooled prevalence of Schistosoma mansoni infection was 37.13% (95%CI:30.02–44.24). High heterogeneity was observed with I2 of 99.4%, P < 0.000. According to subgroup analysis, the pooled prevalence was high in the SNNPR (41.49%: 95%CI: 19.52–63.46) followed by the Amhara region (41.11%: 95%CI: 30.41–51.8), the Tigray region (31.40%: 95%CI:11.72–51.09), and the Oromia region (28.98%: 95%CI: 18.85–39.1). Year from 2011 to 2015 contributed to the highest prevalence of Schistosoma mansoni infection among children (46.31%: 95%:34.21–59.05). Conclusion This study revealed a 37.13% prevalence of Schistosoma mansoni infection among children. This is an alert to improve and implement appropriate control strategies such as mass drug administration in Ethiopia.

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“…Schistosoma mansoni is the predominant cause of schistosomiasis in Ethiopia. Several studies were conducted on the prevalence of S. mansoni in different endemic areas of Ethiopia [20][21][22][23][24]. Understanding the impact of S. mansoni on the human coagulation system and platelet parameters are vital for planning, monitoring, and evaluating strategies to control schistosomiasis-associated morbidity and mortality.…”

Section: Introductionmentioning

confidence: 99%

A Comparative Cross-Sectional Study of Coagulation Profiles and Platelet Parameters of Schistosoma mansoni-Infected Adults at Haik Primary Hospital, Northeast Ethiopia

Bisetegn

Feleke

Ebrahim

et al. 2022

Interdisciplinary Perspectives on Infectious Diseases

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Introduction. Schistosoma mansoni is an intravascular parasite that interacts with all components of the host blood. Nearly, 10% of S. mansoni-infected patients progress to severe hepatosplenic Schistosomiasis is characterized by periportal fibrosis, obstruction of intrahepatic veins, presinusoidal portal hypertension, and splenomegaly. Thus, this study aimed to compare the basic coagulation profiles and platelet parameters of S. mansoni-infected adults and noninfected individuals as controls at Haik Primary Hospital, Northeast Ethiopia. Methods. A comparative cross-sectional study was conducted at Haik Primary Hospital from April to June 2021. The diagnosis and intensity of S. mansoni infection was determined using the Kato–Katz technique. The coagulation profiles and platelet parameters were analyzed using coagulation and hematology analyzers. Data were analyzed using SPSS version 26.0. The Kolmogorov–Smirnov and Shapiro–Wilk tests were done to check the distribution of continuous variables. The Mann–Whitney U test was used to compare the coagulation profiles and platelet parameters. Spearman’s rank-order correlation was done to assess the correlation between the intensity of infection and coagulation profiles and platelet parameters. In all comparison, a P value <0.05 was considered statistically significant. Result. In this study, a total of 180 study participants (90 S. mansoni-infected adults and 90 controls) were included. Of the total S. mansoni-infected adults, 55.6%, 28.9%, 33, and 15.6% had light, moderate, and heavy intensity of infections, respectively. All S. mansoni-infected study participants had prolonged prothrombin time (PT) and international normalized ratio (INR). Moreover, about 80% of S. mansoni-infected adults had prolonged activated partial thromboplastin time (APTT). Thrombocytopenia was found in 26.7% of the S. mansoni-infected adults. The Mann–Whitney U test showed a statistically significant difference in coagulation profiles between S. mansoni-infected adults and healthy controls ( P -value ≤0.001). The Kruskal–Wallis H-test showed a significant difference in PT, APTT, and INR between the intensity of infection and healthy controls ( P -value <0.05). Conclusion. This study showed a prolonged coagulation time in S. mansoni-infected individuals. Thus, screening of schistosomiasis patients for hemostatic abnormalities and treating the underlying disorder is crucial.

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Biogeographical characteristics of Schistosoma mansoni endemic areas in Ethiopia: a systematic review and meta analysis

Cited by 12 publications

References 53 publications

Environmental Drivers and Potential Distribution of Schistosoma mansoni Endemic Areas in Ethiopia

Environmental Drivers and Potential Distribution of Schistosoma mansoni Endemic Areas in Ethiopia

Prevalence of Schistosoma mansoni infection among children in Ethiopia: a systematic review and meta-analysis

A Comparative Cross-Sectional Study of Coagulation Profiles and Platelet Parameters of Schistosoma mansoni-Infected Adults at Haik Primary Hospital, Northeast Ethiopia

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