BioGlue Surgical Adhesive as a Thermal Reflector During Laparoscopic Cryoablation: Effect on Iceball Size and Ablation Zone Diameter

Abstract

In a porcine model, the application of BioGlue did not appear to increase the size of the iceball generated, nor did it change the amount of subjective bleeding noted.

Nanotechnology in Cancer Treatment

“…Although not yet specific on a molecular level, current thermal-ablative approaches do have a high demonstrated success rate with up to 97% positive response using RFA and 98% using LITT for treatment of breast metastases [103] and colorectal cancer metastases [104]. Cryoablation alternatively uses localized low temperatures to freeze and kill neoplastic tissue [105]. Our laboratory demonstrated that DNA-encased MWNTs had the capacity to thermally eradicate prostate cancer xenografts [74] in nude mice model upon near-infrared(NIR) radiation, without causing significant damage to the adjacent tissue.…”

Nanotechnology for cancer treatment

“…Although not yet specific on a molecular level, current thermal-ablative approaches do have a high demonstrated success rate with up to 97% positive response using RFA and 98% using LITT for treatment of breast metastases [103] and colorectal cancer metastases [104]. Cryoablation alternatively uses localized low temperatures to freeze and kill neoplastic tissue [105]. Our laboratory demonstrated that DNA-encased MWNTs had the capacity to thermally eradicate prostate cancer xenografts [74] in nude mice model upon near-infrared(NIR) radiation, without causing significant damage to the adjacent tissue.…”