The article defines the role of the Journal of Elementary Mathematics, the Bulletin of Experimental Physics and Elementary Mathematics, and the “Mathesis” Publishing House in transforming the total knowledge about the technology of teaching natural and scientific disciplines into Science. When organizing the research, for a meaningful analysis of its subject, the analysis of information from publications the generalization of the elements of natural and mathematical knowledge presented in the publications, and the systematization of descriptions of the technology of teaching natural and mathematical disciplines were used. Quantification of text, collection of empirical data, their generalization, and mathematical and statistical processing were used in the process of quantitative analysis. As a result of the research of the materials of both magazines and the products of the “Mathesis” Publishing House during the entire period of their operation, the authors came to the following conclusions. Firstly, from 1886–1925, the ideas of technologies were actively developed in the pages of authoritative publications of the Russian Empire at the time, which functioned in the territory of the Dnipro region – “Journal of Elementary Mathematics”, “Bulletin of Experimental Physics and Elementary Mathematics” and book editions of the “Mathesis” Publishing House teaching of natural and mathematical disciplines, the contents of textbooks and methodical manuals in Mathematics and Natural Sciences were published and discussed, the peculiarities of teacher training were analyzed, methodical schools of outstanding scientists and methodologists were started and fixed, educational programs were reviewed. This shows that thanks to the activities of both magazines and publishing houses, real conditions were created for the meaningful and technological provision of the transitional period from the stage of formation of methodological approaches to the stage of scientific substantiation of the technology of teaching natural and mathematical disciplines in high school in the global context of its formation as a Science. The total volumes of publications, the number of their articles and books, the quality of execution, and the breadth of coverage of the content of natural and mathematical disciplines testify to the ability of editorial offices to carry out the planned measures for the production of substantive and methodical support for teaching and distribution of popular science publications to motivate a wide range of young people (and older members of the population) to study Mathematics, Physics, Astronomy, Biology, Chemistry, and Geography. Both journal editors and the management of the publishing house were aware of the important role of practice in the study of natural and mathematical disciplines – for all analyzed institutions, more than a fourth of the volume of all publications was allocated for problem material and laboratory workshops. Articles and books of a methodological nature became an important component of the publications, in which the peculiarities of the teaching technology were revealed, the subject terminology was clarified, discussions were organized about teaching models, the peculiarities of the speeches of famous mathematicians and natural scientists at various level congresses and congresses were highlighted, and the pedagogical and scientific heritage was disseminated, famous scientists.