Biohydrogenation of C20 polyunsaturated fatty acids by anaerobic bacteria

Sakurama, Haruko; Kishino, Shigenobu; Mihara, Kousuke; Ando, Akinori; Kita, Keiko; Takahashi, Satoshi; Shimizu, Sakayu; Ogawa, Jun

doi:10.1194/jlr.m045450

Cited by 23 publications

(23 citation statements)

References 36 publications

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“…Moreover, Vasta et al (2007) and Schofield et al (2001) suggested that tannins may inhibit the activity of biohydrogenating bacteria because tannins can interfere with bacterial growth. Within the bacterial population residing in the rumen, a number of bacteria that participate in fatty acid saturation have been identified, which include bacteria belonging to the genera Pseudobutyrivibrio and Lactobacillus (Jenkins et al 2008;Sakurama et al 2014). In the present experiment, the abundance of the genera Selenomonas and Butyrivibrio were similar across treatments.…”

Section: Effect Of Unsaturated Fatty Acids Extrusion and Dietary Tansupporting

confidence: 49%

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Effect of partially replacing a barley-based concentrate with flaxseed-based products on the rumen bacterial population of lactating Holstein dairy cows

et al. 2017

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Aims: The effects of partial replacement of a barley-based concentrate with flaxseed-based products on the rumen bacterial population of lactating Holstein dairy cows were evaluated. Methods and Results: Treatments fed were CONT, a normal diet that included barley silage, alfalfa hay and a barley-based concentrate that contained no flaxseed or faba beans; FLAX, inclusion of a nonextruded flaxseed-based product containing 55Á0% flaxseed, 37Á8% field peas and 6Á9% alfalfa; EXT, similar to FLAX, but the product was extruded and EXTT, similar to FLAX, but product was extruded and field peas were replaced by high-tannin faba beans. The rumen bacterial population was evaluated by utilizing 16S rRNA gene sequencing. Most abundant phyla, families and genera were unaffected. However, some taxa were affected; for example, unsaturated fatty acid content was negatively correlated with Clostridiaceae, and tannin content was negatively correlated with BS11 and Paraprevotellaceae. Conclusions: Predominant rumen bacterial taxa were not affected, but the abundance of some taxa found in lower proportions shifted, possibly due to sensitivity to unsaturated fatty acids or tannins. Significance and Impact of the Study: Flaxseed-based products were effective for partially replacing barley-based concentrate in rations of lactating dairy cows. No negative effects of these products were observed on the abundance of predominant rumen bacterial taxa, with only minor shifts in less abundant bacteria.

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Section: Effect Of Unsaturated Fatty Acids Extrusion and Dietary Tansupporting

confidence: 49%

“…; Sakurama et al . ). In the present experiment, the abundance of the genera Selenomonas and Butyrivibrio were similar across treatments.…”

Section: Discussionmentioning

confidence: 97%

Effect of partially replacing a barley-based concentrate with flaxseed-based products on the rumen bacterial population of lactating Holstein dairy cows

et al. 2017

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“…[39, 40] Comorbidities and access to health care may also confound our findings; however, given the population studied, we would expect the latter to be diminished. Moreover, although comorbidities have may influence overall survival,[41, 42] such diseases are less likely to affect CRC-specific mortality,[43] the primary endpoint of this study. In addition, only a fraction of patients providing post-diagnosis data were included in this study.…”

Section: Discussionmentioning

confidence: 99%

Marine ω-3 polyunsaturated fatty acid intake and survival after colorectal cancer diagnosis

Song

Zhang

Meyerhardt

et al. 2016

Gut

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Objective Experimental evidence supports an antineoplastic activity of marine omega-3 polyunsaturated fatty acids (ω-3 PUFAs; including eicosapentaenoic acid, docosahexaenoic acid, and docosapentaenoic acid). However, the influence of ω-3 PUFAs on colorectal cancer (CRC) survival is unknown. Design Within the Nurses’ Health Study and Health Professionals Follow-up Study, we prospectively studied CRC-specific and overall mortality in a cohort of 1,659 CRC patients according to intake of marine ω-3 PUFAs and its change after diagnosis. Results Higher intake of marine ω-3 PUFAs after CRC diagnosis was associated with lower risk of CRC-specific mortality (P for trend=0.03). Compared with patients who consumed less than 0.10 g/day of marine ω-3 PUFAs, those consuming at least 0.30 g/day had an adjusted hazard ratio for CRC-specific mortality of 0.59 (95% confidence interval [CI], 0.35 to 1.01). Patients who increased their marine ω-3 PUFA intake by at least 0.15 g/day after diagnosis had a hazard ratio of 0.30 (95% CI, 0.14 to 0.64, P for trend<0.001) for CRC deaths, compared with those who did not change or changed their intake by less than 0.02 g/day. No association was found between post-diagnostic marine ω-3 PUFA intake and all-cause mortality (P for trend=0.47). Conclusion High marine ω-3 PUFA intake after CRC diagnosis is associated with lower risk of CRC-specific mortality. Increasing consumption of marine ω-3 PUFAs after diagnosis may confer additional benefits to patients with CRC.

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“…These two omega-3 fatty acids have been reported to have some differing metabolic (59) effects and EPA has been reported to be the more anti-inflammatory fatty acid (60). It is conceivable that intestinal microbiota, which differ between individuals, could biodegrade n-3 fatty acids (61) and alter their absorption. This is unlikely to have occurred in a major way in our study since red cell phospholipid DHA content increased so markedly…”

Section: Discussionmentioning

confidence: 99%

Docosahexaenoic acid supplementation is not anti-inflammatory in adipose tissue of healthy obese postmenopausal women

Holt

Alemán

Walker

et al. 2017

IJN

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Adipose tissue inflammation is associated with obesity comorbidities. Reducing such inflammation may ameliorate these comorbidities. n-3 fatty acids have been reported to have anti-inflammatory properties in obesity, which may modulate this inflammatory state. In the current study a 1 gram per day oral supplement of the n-3 fatty acid docosahexaenoic acid (DHA) was administered for 12 weeks to 10 grade 1-2 obese postmenopausal women and markers of adipose tissue and systemic inflammation measured and compared before and after supplementation. DHA administration resulted in approximately a doubling of plasma and red cell phospholipid and adipose tissue DHA content but no change in systemic markers of inflammation, such as circulating C-reactive protein (CRP) or interleukins (IL) 6, 8 and 10 (IL-6, IL-8, IL-10). DHA supplementation did not alter the adipose tissue marker of inflammation crown-like structure density nor did it affect any gene expression pathways, including anti-inflammatory, hypoxic and lipid metabolism pathways. The obese postmenopausal women studied were otherwise healthy, which leads us to suggest that in such women DHA supplementation is not an effective means for reducing adipose tissue or systemic inflammation. Further testing is warranted to determine if n-3 fatty acids may ameliorate inflammation in other, perhaps less healthy, populations of obese individuals.

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Biohydrogenation of C20 polyunsaturated fatty acids by anaerobic bacteria

Cited by 23 publications

References 36 publications

Effect of partially replacing a barley-based concentrate with flaxseed-based products on the rumen bacterial population of lactating Holstein dairy cows

Effect of partially replacing a barley-based concentrate with flaxseed-based products on the rumen bacterial population of lactating Holstein dairy cows

Marine ω-3 polyunsaturated fatty acid intake and survival after colorectal cancer diagnosis

Docosahexaenoic acid supplementation is not anti-inflammatory in adipose tissue of healthy obese postmenopausal women

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