“…Faced with chemical, physical, and microbial aggressions, the pulp–dentin complex responds by combining inflammation with the production of tertiary or reactive dentin due to stimuli experienced by the odontoblasts ( Chaves et al, 2022a , Chaves et al, 2022b ). The pulp tissue defense pathways occur concomitantly and the inflammatory response orchestrates tissue activity, being related to the ability of pulp cells to organize an immunological response against aggressors ( Moore et al, 2022 , Kale et al, 2022 ).…”