Bioinformatic Analysis of Diagnosis, Targeted Therapeutic Values and Potential Regulatory Network of FOXF1 in Ovarian Cancer

Abstract

Background: FOXF1 acts a crucial part to tumor initiation and progression. In this study, we aimed to analyzed FOXF1 in ovarian cancer from different databases which showed diagnosis and targeted therapeutic values.Results: The expression of FOXF1 in ovarian cancer tissue was markedly lower than that in normal tissue. Among different tumor subgroups, FOXF1 expression was conspicuously lower in higher grade stage. Additionally, FOXF1 expression and genetic variations were significantly correlated with various immune infiltrating cells. Altogether, 2594 co-expressed genes evidently pertinent to FOXF1. These genes were correlated with cell adhesion, NADH dehydrogenase complex and cytokine binding in results of enrichment analysis. In addition, FOXF1 was associated with gene networks regulated by PRKG1, miR-151, and SRF respectively. CMap analysis screened several potential small molecules for ovarian cancer treatment.Conclusions: FOXF1 has been shown to be a vital biomarker for the diagnosis of ovarian cancer and the immune infiltrating levels. The small molecules screened here supply rationale for new drug development for ovarian cancer.