Bioinformatic Analysis Of Epithelial Cell Gene Expression In Chronic Rhinosinusitis Identifies Constitutive Differences Between CRSwNP And CRSsNP

Expression of the extracellular matrix gene periostin is increased in chronic rhinosinusitis and decreases following successful endoscopic sinus surgery

“…In CRS, a potential role for dysregulation of the ECM is suggested by pooling‐based genomewide association studies (p‐GWAS) identifying ECM genes (FBLN1, LAMB1, LAMA2) as top candidates 2,3. Further support for a potential role of the ECM in the pathogenesis of CRS is afforded by the demonstration of increased expression of periostin (POSTN), a component of the ECM, in CRS biopsy samples.…”

An Evaluation of SPARC Protein as a Serum Biomarker of Chronic Rhinosinusitis

“…SPARC (secreted protein acidic and rich in cysteine), also known as osteonectin, belongs to the basic HLH factors. 17 We have previously described elevated SPARC expression patterns in gene expression profiles of primary epithelial cultures raised from CRS mucosal biopsies, 18 which prompted our current investigation. Our objective in this study was to evaluate the SPARC protein in serum as a biomarker of EMT activation in patients with CRS.…”

Clinical features of cytotoxic CD8+ T‐lymphocyte deficiency in chronic rhinosinusitis patients: a demographic and functional study

“…Evidence for a role in immune deficiency in CRS has already been suggested by studies of innate immunity in CRS by the documentation of reduced number of Toll‐like receptor 2 (TLR2) receptors in patients with CRS and a reduced function of TLR2 receptors in epithelial cells cultured from CRS subjects . Altered function of major histocompatibility complex class I (MHCI) molecules and/or of CD8 lymphocyte functions may also play a role.…”