Bioinformatic Investigation of Micro RNA-802 Target Genes, Protein Networks,  and Its Potential Prognostic Value in Breast Cancer

Eini, Maryam; Parsi, Sepideh; Barati, Mahmood; Bahramali, Golnaz; Zarei, Marziyeh Alizadeh; Kiani, Jafar; Azarnezhad, Assad; Hosseini, Arshad

doi:10.18502/ajmb.v14i2.8882

Cited by 2 publications

(1 citation statement)

References 75 publications

(72 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…4,5 Based on WHO reports, the worldwide BC patients will step-up from 2 069 792 to 2 778 850 instances from 2018 to 2040, indicating the importance of further research about the disease's molecular basis. 6 The current trend emphasizes the necessity for deeper insights into the molecular biology of BC. 7 MicroRNAs(miRNA/miR), one of the noncoding single-stranded RNAs with a length of 18-22 nucleotides, are involved in diverse biological activities.…”

Section: Introductionmentioning

confidence: 99%

Effect of microRNA-141-3p, E2F3, CDK3, and KAT2B overexpression on histologic tumor grade and metastasis status in untreated breast cancer tissues

Ebrahimian Vargahan,

Barati,

Roudbari

et al. 2024

Bioimpacts

View full text Add to dashboard Cite

Introduction: Increasing evidence has reported gene expression alterations in breast cancer (BC) tissues, necessitating their investigating to highlight the molecular basis of the disease development or progression. This study investigated the expression of miR-141, E2F3, CDK3, TP53, and KAT2B, and their association with histologic grade and metastasis in BC tissues. Methods: The RNA expression level of miR-141, E2F3, CDK3, TP53, and KAT2B genes was analyzed in 23 BC and 23 normal tissue samples by RT-qPCR. The associations of the expression level of these genes with clinicopathological features of the BC tissue samples were evaluated. The study also explored the correlation between RNA levels of genes and miR-141. Results: Expression of miR-141, E2F3, CDK3, and KAT2B demonstrated significantly higher levels in BC tumor than normal tissues. TP53 expression showed an increase in tumor compared to normal tissues, although it was insignificant. Moreover, increased RNA expression of miR-141, E2F3, CDK3, and KAT2B corresponded to the advanced stage and regional metastasis of BC. Additionally, the results demonstrated a significant correlation between RNA expression levels of miR-141 with CDK3 and E2F3 with KAT2B. Conclusion: Our findings highlighted clinicopathologic indicators that were relevant to aggressive BC. Besides, Correlations between overexpression of miR-141, E2F3, CDK3, and KAT2B in BC tissues suggest regulatory effects. Taken together, it seems results of this study could provide evidence that dysregulation of gene expression contributes significantly to unveiling the underlying molecular basis of BC.

show abstract

Section: Introductionmentioning

confidence: 99%

Effect of microRNA-141-3p, E2F3, CDK3, and KAT2B overexpression on histologic tumor grade and metastasis status in untreated breast cancer tissues

Ebrahimian Vargahan,

Barati,

Roudbari

et al. 2024

Bioimpacts

View full text Add to dashboard Cite

show abstract

Elucidating hepatocellular carcinoma progression: a novel prognostic miRNA–mRNA network and signature analysis

Wang,

Kang,

et al. 2024

Sci Rep

View full text Add to dashboard Cite

There is increasing evidence that miRNAs play an important role in the prognosis of HCC. There is currently a lack of acknowledged models that accurately predict patient prognosis. The aim of this study is to create a miRNA-based model to precisely forecast a patient’s prognosis and a miRNA–mRNA network to investigate the function of a targeted mRNA. TCGA miRNA dataset and survival data of HCC patients were downloaded for differential analysis. The outcomes of variance analysis were subjected to univariate and multivariate Cox regression analyses and LASSO analysis. We constructed and visualized prognosis-related models and subsequently used violin plots to probe the function of miRNAs in tumor cells. We predicted the target mRNAs added those to the String database, built PPI protein interaction networks, and screened those mRNA using Cytoscape. The hub mRNA was subjected to GO and KEGG analysis to determine its biological role. Six of them were associated with prognosis: hsa-miR-139-3p, hsa-miR-139-5p, hsa-miR-101-3p, hsa-miR-30d-5p, hsa-miR-5003-3p, and hsa-miR-6844. The prognostic model was highly predictive and consistently performs, with the C index exceeding 0.7 after 1, 3, and 5 years. The model estimated significant differences in the Kaplan–Meier plotter and the model could predict patient prognosis independently of clinical indicators. A relatively stable miRNA prognostic model for HCC patients was constructed, and the model was highly accurate in predicting patients with good stability over 5 years. The miRNA–mRNA network was constructed to explore the function of mRNA.

show abstract

Bioinformatic Investigation of Micro RNA-802 Target Genes, Protein Networks, and Its Potential Prognostic Value in Breast Cancer

Cited by 2 publications

References 75 publications

Effect of microRNA-141-3p, E2F3, CDK3, and KAT2B overexpression on histologic tumor grade and metastasis status in untreated breast cancer tissues

Effect of microRNA-141-3p, E2F3, CDK3, and KAT2B overexpression on histologic tumor grade and metastasis status in untreated breast cancer tissues

Elucidating hepatocellular carcinoma progression: a novel prognostic miRNA–mRNA network and signature analysis

Contact Info

Product

Resources

About