Bioinformatic prediction of depression-related signaling pathways regulated by miR-146a in peripheral blood of patients with post-stroke depression

Jionoside A1 alleviates ischemic stroke ischemia/reperfusion injury by promoting Nix-mediated mitophagy

“…Despite the fact that this work demonstrates that Jionoside A1 can reduce ischemic stroke ischemia/reperfusion injury by encouraging Nix-mediated mitophagy, Jionoside A1's protective effects are probably not exclusive to this pathway. In the process of ischemic stroke ischemia/reperfusion injury, many damaged mitochondria emerge (4,5). The increase in mitochondrial content under Jionoside A1 administration may also be accompanied by accelerated mitochondrial biogenesis, which could be caused by Jionoside A1 administration or a compensatory effect of mitophagy activation.…”

“…The process of restoring blood flow and inducing reperfusion injury heeding cerebral ischemia is commonly referred to as cerebral ischemia/reperfusion (I/R) injury. The mitochondrial respiratory chain's function is compromised in the initial stages of ischemia/ reperfusion injury (3), and this impairment lasts for at least a week (4,5). When the brain is injured by cerebral ischemia/reperfusion (I/R), mitochondrial damage can result in neuronal death, which affects neural function (6,7).…”

Huatanmaitong tablet alleviate cerebral ischemic reperfusion injury with hyperlipidaemia in rats by regulating OATPs/VEGF axis

“…Ischemic stroke can result in severe neurological impairments, including consciousness disorders, limb paralysis, and cognitive decline, imposing significant economic and social burdens on affected regions (2). Hyperlipidemia has been established as a vital risk factor for ischemic stroke (3). Relevant studies have confirmed an increase in serum cholesterol levels within a population could lead to an estimated 9.2 million additional cardiovascular events between 2010 and 2030 (4,5).…”