The purpose of this chapter is to introduce the information science reader to the wide range of data and other resources that constitute "biological information". Attention is paid to both paper and digital sources and the use of digital libraries and cyberinfrastructure for the creation, use, and re-use of information. The chapter discusses various user communities and their needs, including scientists, educators and students, policymakers, and other secondary users. The chapter concludes with challenges for data sharing, preservation, and access.