Bioinformatics analysis and experimental validation reveal that CDC20 overexpression promotes bladder cancer progression and potential underlying mechanisms

Liu, Yuan; Zou, Shao-hui; Gao, Xin

doi:10.1007/s13258-024-01505-x

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2024

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Cited by 3 publications

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Impact of potential biomarkers, SNRPE, COX7C, and RPS27, on idiopathic Parkinson’s disease

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Over-expression of KRT17 and MDK genes at mRNA levels in urine-exfoliated cells is associated with early non-invasive diagnosis of non-muscle-invasive bladder cancer

Dayati,

Shakhssalim,

Allameh

2024

Clinical Biochemistry

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Prognostic Impact and Therapeutic Potential of CDC20 in Cervical Cancer: Insights from Clinical and Experimental Analyses

Xian,

Zhu,

Zhang

et al. 2024

Preprint

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CDC20 has been identified as an oncogene involved in the development and prognosis of various cancers, yet its role in cervical cancer remains unclear. This study aimed to evaluate CDC20 expression in cervical cancer tissues and its clinical significance. We conducted a retrospective analysis of 249 cervical cancer patients diagnosed at Nanchong Central Hospital from January to December 2022. Immunohistochemistry was used to assess CDC20 expression, and statistical methods compared clinicopathological characteristics. Survival analysis employed the Kaplan-Meier method, and Cox regression identified survival risk factors. Additionally, siRNA was used to knock down CDC20 in HeLa cells to examine its effects on proliferation, invasion, and migration. Results indicated that CDC20 expression was significantly higher in cervical cancer tissues (61.85%) compared to adjacent normal tissues (7.5%) (p < 0.05). High CDC20 expression was associated with poorer overall survival, particularly in specific subgroups (p < 0.05) and identified as an independent risk factor (p < 0.05). Silencing CDC20 inhibited cancer cell proliferation and invasion, while xenograft models demonstrated reduced tumor growth with CDC20 inhibition (p < 0.01). CDC20 may serve as a valuable prognostic biomarker and therapeutic target for cervical cancer.

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Bioinformatics analysis and experimental validation reveal that CDC20 overexpression promotes bladder cancer progression and potential underlying mechanisms

Cited by 3 publications

References 30 publications

Impact of potential biomarkers, SNRPE, COX7C, and RPS27, on idiopathic Parkinson’s disease

Impact of potential biomarkers, SNRPE, COX7C, and RPS27, on idiopathic Parkinson’s disease

Over-expression of KRT17 and MDK genes at mRNA levels in urine-exfoliated cells is associated with early non-invasive diagnosis of non-muscle-invasive bladder cancer

Prognostic Impact and Therapeutic Potential of CDC20 in Cervical Cancer: Insights from Clinical and Experimental Analyses

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