Bioinformatics analysis and tissue-specific expression of intestinal-type fatty acid binding protein in domestic pigeons (<i>Columba livia</i>)

Xu, Xiu; Mao, Hai Guang; Liu, Hong Hua; Dong, Xin; Zou, Xiao Ting; Yin, Zhonglong

doi:10.1080/09712119.2020.1735397

Cited by 2 publications

(1 citation statement)

References 27 publications

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“…FABP2 is similarly found in enterocytes and has been established to play roles in the absorption of dietary fatty acids in the gut [ 37 ]. Its content in the systemic circulation serves as a biomarker for human intestinal disorders such as necrotizing enterocolitis and ileitis [ 38 ]. FABP6 is also present in the distal region of the small intestine, wherein it functions as an intracellular transporter of bile acids in ileal epithelial cells, assisting in the catalysis and metabolism of cholesterol [ 39 ].…”

Section: Fatty Acid-binding Proteinsmentioning

confidence: 99%

Fatty Acid-Binding Proteins: Their Roles in Ischemic Stroke and Potential as Drug Targets

Guo

Kawahata

Cheng

et al. 2022

IJMS

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Stroke is among the leading causes of death and disability worldwide. However, despite long-term research yielding numerous candidate neuroprotective drugs, there remains a lack of effective neuroprotective therapies for ischemic stroke patients. Among the factors contributing to this deficiency could be that single-target therapy is insufficient in addressing the complex and extensive mechanistic basis of ischemic brain injury. In this context, lipids serve as an essential component of multiple biological processes and play important roles in the pathogenesis of numerous common neurological diseases. Moreover, in recent years, fatty acid-binding proteins (FABPs), a family of lipid chaperone proteins, have been discovered to be involved in the onset or development of several neurodegenerative diseases, including Alzheimer’s and Parkinson’s disease. However, comparatively little attention has focused on the roles played by FABPs in ischemic stroke. We have recently demonstrated that neural tissue-associated FABPs are involved in the pathological mechanism of ischemic brain injury in mice. Here, we review the literature published in the past decade that has reported on the associations between FABPs and ischemia and summarize the relevant regulatory mechanisms of FABPs implicated in ischemic injury. We also propose candidate FABPs that could serve as potential therapeutic targets for ischemic stroke.

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Section: Fatty Acid-binding Proteinsmentioning

confidence: 99%

Fatty Acid-Binding Proteins: Their Roles in Ischemic Stroke and Potential as Drug Targets

Guo

Kawahata

Cheng

et al. 2022

IJMS

View full text Add to dashboard Cite

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The Effects of Acidifier Inclusion in the Diet on Growth Performance, Gastrointestinal Health, Ileal Microbial Population, and Gene Expression in Broilers

Sedghi,

Azghadi,

Mohammadi

et al. 2024

Braz. J. Poult. Sci.

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The purpose of this study was to investigate the effects of acidifier on broilers' performance. A total of 648-day-old broilers were assigned to four treatments (0, 1, 2, and 3 g/kg acidifier in the diet). In the grower period, the acidifier inclusion resulted in a higher average daily weight gain (ADWG) than in the control. On the 40th day of age, 3 g/ kg of acidifier increased ADWG and average daily feed intake (ADFI). The highest ADWG was observed in the 3 g/kg of acidifier treatment for the whole period. Orthogonal contrast between acidifier and control indicated that cholesterol and high-density lipoprotein (HDL) concentration in the serum was lower in the acidifier-fed broilers. Inclusion of 2 and 3 g/kg of acidifier reduced Salmonella population in the ileum. Adding 2 and 3 g/kg acidifier to the diet increased crypt depth compared to other treatments. Weight and length of the tibia were also significantly increased by acidifier. The quadratic effect showed that the acidifier had a significant effect on the tibio-tarsal index. The mRNA expression of PPARγ and Toll-Like Receptor 4 (TLR4) genes in the ileum of broilers that were fed 3 g/kg acidifier was significantly higher than in other treatments. Fatty Acid-Binding Protein 1 gene showed a significant enhancement effect by the acidifier: with increasing levels of acidifier, its expression also increased. In conclusion, the acidifier improved the performance, upregulated the expression of ileal fatty acid-binding protein 1 (FABP1), TLR4, and PPARγ genes, as well as increased the tibia length, and reduced the Salmonella population in the ileum.

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Bioinformatics analysis and tissue-specific expression of intestinal-type fatty acid binding protein in domestic pigeons (Columba livia)

Cited by 2 publications

References 27 publications

Fatty Acid-Binding Proteins: Their Roles in Ischemic Stroke and Potential as Drug Targets

Fatty Acid-Binding Proteins: Their Roles in Ischemic Stroke and Potential as Drug Targets

The Effects of Acidifier Inclusion in the Diet on Growth Performance, Gastrointestinal Health, Ileal Microbial Population, and Gene Expression in Broilers

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