Bioinformatics analysis of structure and function in the MRP gene family and its expression in response to various drugs in Bursaphelenchus xylophilus

Diao, Jian; Hao, Xin; Ma, Wei; Ma, Ling

doi:10.1007/s11676-019-01086-6

Cited by 7 publications

(2 citation statements)

References 29 publications

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“…In addition, the combination of P-gp interfering or MDR-reversal agents with IVM potentiated sensitivity to IVM in adults and microfilariae of B. malayi following overexpression of multiple ABC transporter genes in response to IVM exposure [ 97 ]. Recently, Diao et al [ 98 ] reported that the expression of multiple Bx-MRP genes increased in the pine wood nematode, Bursaphelenchus xylophilus , with increasing concentrations of emamectin benzoate, avermectin and matrine, suggesting a potential role in the regulation of multidrug resistance.…”

Section: Abc Transporters and Drug Resistance In Nematodes/evidence F...mentioning

confidence: 99%

Importance of ABC Transporters in the Survival of Parasitic Nematodes and the Prospect for the Development of Novel Control Strategies

2023

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ABC transporters, a family of ATP-dependent transmembrane proteins, are responsible for the active transport of a wide range of molecules across cell membranes, including drugs, toxins, and nutrients. Nematodes possess a great diversity of ABC transporters; however, only P-glycoproteins have been well-characterized compared to other classes. The ABC transport proteins have been implicated in developing resistance to various classes of anthelmintic drugs in parasitic nematodes; their role in plant and human parasitic nematodes still needs further investigation. Therefore, ABC transport proteins offer a potential opportunity to develop nematode control strategies. Multidrug resistance inhibitors are becoming more attractive for controlling nematodes due to their potential to increase drug efficacy in two ways: (i) by limiting drug efflux from nematodes, thereby increasing the amount of drug that reaches its target site, and (ii) by reducing drug excretion by host animals, thereby enhancing drug bioavailability. This article reviews the role of ABC transporters in the survival of parasitic nematodes, including the genes involved, their regulation and physiological roles, as well as recent developments in their characterization. It also discusses the association of ABC transporters with anthelmintic resistance and the possibility of targeting them with next-generation inhibitors or nutraceuticals (e.g., polyphenols) to control parasitic infections.

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Section: Abc Transporters and Drug Resistance In Nematodes/evidence F...mentioning

confidence: 99%

Importance of ABC Transporters in the Survival of Parasitic Nematodes and the Prospect for the Development of Novel Control Strategies

2023

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“…Pine wood nematode (PWN) (Bursaphelenchus xylophilus (Steiner & Buhrer) Nickle)) is the pathogen of pine wilt disease (PWD). Due to its complex pathogenic mechanism [1,2] and drug resistance [3], as well as the poor resistance of the host pine to pine wood nematode [4,5], the disease has become a major threat to pine forests worldwide, remaining a concern for many countries. The population genetics, geographical origin, and spread of PWN have also received much attention [6,7].…”

Section: Introductionmentioning

confidence: 99%

Genetic Diversity and Population Structure of Bursaphelenchus xylophilus in Guangdong, Guangxi, and Jiangsu Provinces in China

Feng,

Jian,

Ding

et al. 2024

Forests

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This study aimed to investigate the genetic structures of pine wood nematodes (PWNs, Bursaphelenchus xylophilus (Steiner & Buhrer) Nickle)), in Guangdong (GD), Guangxi (GX), and Jiangsu (JS) Provinces (the major PWN dispersal centers). Furthermore, we also explored potential migration routes among the different provinces in order to provide insights into the epidemic source of PWNs in the three provinces in China. We re-sequenced a total of 241 PWNs collected from the above provinces using next-generation sequencing to obtain raw genomic data. Bioinformatics analysis was used to identify the SNPs, genetic structures, and selective sweeps of the PWNs. The results indicate that the PWNs from these three provinces can be classified into five groups (A, B, C, D, and E), among which the genetic variations are significant. All PWN strains from JS were exclusively found in Group A. The PWNs in Groups B and C were composed of strains from GD and GX, while Groups D and E comprised only GD strains. Introgression analysis identified two possible pathways: (1) from Group A to Group B-GX and (2) from Group E to Group D. Selective sweep analysis showed that in Groups B and C, the candidate genes of Group B were mainly related to pectin lyase activity.

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Nematicidal phytochemicals against pine wood nematode, Bursaphelenchus xylophilus (nematoda: aphelenchoididae)

Feng

Wang

et al. 2022

J Plant Dis Prot

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Bioinformatics analysis of structure and function in the MRP gene family and its expression in response to various drugs in Bursaphelenchus xylophilus

Cited by 7 publications

References 29 publications

Importance of ABC Transporters in the Survival of Parasitic Nematodes and the Prospect for the Development of Novel Control Strategies

Importance of ABC Transporters in the Survival of Parasitic Nematodes and the Prospect for the Development of Novel Control Strategies

Genetic Diversity and Population Structure of Bursaphelenchus xylophilus in Guangdong, Guangxi, and Jiangsu Provinces in China

Nematicidal phytochemicals against pine wood nematode, Bursaphelenchus xylophilus (nematoda: aphelenchoididae)

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