2023
DOI: 10.1186/s12890-023-02584-4
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Bioinformatics analysis of the immune cell infiltration characteristics and correlation with crucial diagnostic markers in pulmonary arterial hypertension

Abstract: Background Pulmonary arterial hypertension (PAH) is a pathophysiological syndrome, characterized by pulmonary vascular remodeling. Immunity and inflammation are progressively recognized properties of PAH, which are crucial for the initiation and maintenance of pulmonary vascular remodeling. This study explored immune cell infiltration characteristics and potential biomarkers of PAH using comprehensive bioinformatics analysis. Methods Microarray dat… Show more

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Cited by 2 publications
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“…Pulmonary hypertension (PH) is characterized by remodeling of the pulmonary artery, resulting in irreversible right heart failure and progressive symptoms that often lead to fatality. The extracellular matrix remodeling and fibrosis in the pulmonary vessels, which correlate with loss of compliance, have been linked to chronic perivascular inflammation and immune dysregulation [1][2][3]. Among the five subtypes of PH, group 1 is known as pulmonary arterial hypertension (PAH) [4].…”
Section: Introductionmentioning
confidence: 99%
“…Pulmonary hypertension (PH) is characterized by remodeling of the pulmonary artery, resulting in irreversible right heart failure and progressive symptoms that often lead to fatality. The extracellular matrix remodeling and fibrosis in the pulmonary vessels, which correlate with loss of compliance, have been linked to chronic perivascular inflammation and immune dysregulation [1][2][3]. Among the five subtypes of PH, group 1 is known as pulmonary arterial hypertension (PAH) [4].…”
Section: Introductionmentioning
confidence: 99%