“…GPX2 overexpression has been characterized in several cancers such as colorectal adenomas and carcinomas, as well as promoting progression of lung adenocarcinomas [ [28] , [29] , [30] ]. Though, the effects of the upregulation of GPXs are not entirely clear; in some cases (and with some genetic variants) this is associated with improved prognosis, tumor suppression, and even increased sensitivity to chemotherapeutics, while several cancer types instead exhibit decreases in GPX expression [ [30] , [31] , [32] , [33] ]. Fig.…”
“…GPX2 overexpression has been characterized in several cancers such as colorectal adenomas and carcinomas, as well as promoting progression of lung adenocarcinomas [ [28] , [29] , [30] ]. Though, the effects of the upregulation of GPXs are not entirely clear; in some cases (and with some genetic variants) this is associated with improved prognosis, tumor suppression, and even increased sensitivity to chemotherapeutics, while several cancer types instead exhibit decreases in GPX expression [ [30] , [31] , [32] , [33] ]. Fig.…”
“…Some of them are being studied with cancerous diseases. But, on the other hand, different GPx subtypes play different roles in tumors, and the mechanisms of action need to be studied further [13][14][15][16]. In the presented catalytic cycle of H 2 O 2 reduction by GPx, the active selenol of L-Sec 2, maintained in its ionized form through a hydrogen bond network with the neighboring amino acid environment (glutamine and tryptophan residues [17]) is first oxidized to the selenenic acid 3, and further regenerated in the presence of two GHS molecules.…”
A series of unsymmetrical phenyl β-carbonyl selenides with o-amido function substituted on the nitrogen atom with chiral alkyl groups was obtained. The compounds form a series of enantiomeric and diastereomeric pairs and present the first examples of this type of chiral Se derivatives. All obtained selenides were further evaluated as antioxidants and anticancer agents to define the influence of the particular stereochemistry of the attached functional groups on the bioactivity of the molecules. The highest H2O2 reduction potential was observed for N-(cis-2-hydroxy-1-indanyl)-2-((2-oxopropyl)selanyl)benzamide, and the best radical scavenging properties for N-(-1-hydroxy-2-butanyl)-2-((2-oxopropyl)selanyl)benzamide. Also, both enantiomers of the N-(1-hydroxy-2-butanyl) selenide expressed the highest cytotoxic potential towards human promyelocytic leukemia HL-60 cell line with similar IC50 values 14.4 ± 0.5 and 16.2 ± 1.1 µM, respectively. On the other hand, breast cancer cell line MCF-7 was most sensitive to N-((R)-(-)-1-hydroxy-2-butanyl)- 2-((2-oxopropyl)selanyl)benzamide (IC50 of 35.7 ± 0.6 µM). The structure–activity dependence of the obtained Se derivatives was discussed, and the most potent compounds were selected.
Prosopis farcta was previously used in folk medicine as a dry fruit to relieve pain before its active biological components that contribute to this were known. This study assessed the effectiveness of a dry fruit extract of P. farcta by measuring the indicators of inflammation in albino rats after they were dosed with ethanol. As such, looking at the antioxidant potential of P. farcta fruit aqueous extract (PFFAE) in resistance to ethanol's harm in rats given ethanol showed a notable increase in serum C reactive protein (CRP), malondialdehyde (MDA), CRP/ALB ratio (CAR), and WBC count. At the same time, glutathione peroxidase (GPx) and albumin were markedly reduced. PFFAE diminished ethanol-induced amounts of CRP, MDA, and CAR in plasma; additionally, it strengthened the ethanol-induced decline in GPx activity, and albumin had no apparent effect on the ESR level. Consequently, the current findings demonstrate that PFFAE counteracts the toxicity of ethanol and has a protective impact against the ethanol effect.
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