Bioinformatics analysis reveals three key genes and four survival genes associated with youth-onset NSCLC

Abstract

Youth-onset non-small cell lung cancer (NSCLC) is a heterogeneous disease. It has a unique clinicopathology and special genetic background. In this study, three key genes, CDC20, CCNB2, and BUB1, have been identified in youth-onset NSCLC tumor tissues based on the TCGA and GEO cohorts. Functional enrichment analysis reveals that the “oocyte meiosis,” “cell cycle,” and the “P53 signaling pathway” are significantly enriched. Additionally, four survival genes, including AKAP12, CRIM1, FEN1, and SLC7A11, that affect the prognosis of youth-onset NSCLC patients are identified in this study. Finally, we construct a risk model to predict the overall survival of youth-onset NSCLC patients, the AUC of the risk model in 1, 3, and 5 years of overall survival is 0.808, 0.844, and 0.728. This study aims to provide a novel idea to explore the pathogenic genes of youth-onset NSCLC.

Key genes involved with prognosis were identified in lung adenocarcinoma by integrated bioinformatics analysis

“…In addition, as a heterogeneous disease. Based on TCGA and GEO databases, CDC20 and CCNB2 may be the pathogenic genes of young-onset non-small cell lung cancer [ 30 ]. More importantly, based on genome-wide association analysis of GWAS, many key genes associated with lung adenocarcinoma were identified through co-expression networks, including CCNB2, which plays a key role in the cell cycle [ 31 ].…”

Silencing of long non-coding RNA SDCBP2-AS1/microRNA-656-3p/CRIM1 axis promotes ferroptosis of lung cancer cells

“…It is newly identified to promote tumor cell migration and adhesion in lung cancer (26). In addition, CRIM1 may be a prognosis biomarker of lung cancer (27). However, whether CRIM1 was associated with ferroptosis remains unknown.…”

Advancements in the diagnosis and treatment of sub‑centimeter lung cancer in the era of precision medicine (Review)

“…Notably, KRAS mutations are associated with a higher rate of CD8 + T cell infiltration, stronger proliferative and immunosuppressive signals ( 92 , 102 , 104 ). ALK mutations are more frequently observed in young adults and are mainly diagnosed at an advanced tumor stage ( 100 , 105 , 106 ). It is worth mentioning that ALK mutation is associated with EGFR mutation, suggesting an increased malignant potential leading to decreased OS of patients ( 105 ).…”