The research is based on a comprehensive analysis of scientific articles devoted to the problems of obtaining, storing and using genomic information about a person. As a result of the analysis, the author put forward a hypothesis about the interdisciplinary interaction of social sciences and humanities in the process of research, the object of which is the human genome. The study tests the proposed hypothesis on the basis of the disclosure of its subject - the human genome as an object of interdisciplinary social and humanitarian research and the system of methodological means corresponding to them. During the research, the author relied on the general philosophical means of the methodology of science (categories of materialistic dialectics, foundations, conditions and principles of scientific knowledge), the systemstructural method and general logical methods (analogy, synthesis, analysis) used in socio-humanitarian studies. As a result of the study, it was concluded that the special significance of the consequences of the study and use of human genome for society and each individual personally determines the a priori social and humanitarian interdisciplinary connections, due to which human genome becomes the object of interdisciplinary social and humanitarian research. The analysis of these studies allowed revealing their subject orientation towards the social regulation of genomic research, the legal protection of genomic information and the focus on standardization (and in this sense, foreseeability) of research on human genome and the use of their results. At the same time, the use of methodological means of three levels is traced: philosophical and methodological analysis, general scientific methodological principles and a special scientific methodological approach.