Bioinspired application of dendrimers: From bio-mimicry to biomedical applications

Jang, Woo Dong; Selim, K. M. Kamruzzaman; Lee, Chi Hwa; Kang, Inn Kyu

doi:10.1016/j.progpolymsci.2008.08.003

Cited by 191 publications

(58 citation statements)

References 145 publications

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“…They have been used efficiently as imaging agents in radiotherapy, X-ray, and magnetic resonance imaging (MRI). 31,32 In X-ray technology, substances of high molecular weight are preferred over low molecular weight as the latter substances equilibrate readily within the extracellular fluid and intravascular compartments of the body. For this reason, they are used to detect disease-induced lesions or view organs such as kidneys, bones, tumors, and arteriosclerotic vasculature.…”

Section: Diagnostic Applicationsmentioning

confidence: 99%

Dendrimers as tunable vectors of drug delivery systems and biomedical and ocular applications

Kalomiraki¹,

Thermos²,

Chaniotakis³

2015

IJN

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Abstract:Dendrimers are large polymeric structures with nanosize dimensions (1-10 nm) and unique physicochemical properties. The major advantage of dendrimers compared with linear polymers is their spherical-shaped structure. During synthesis, the size and shape of the dendrimer can be customized and controlled, so the finished macromolecule will have a specific "architecture" and terminal groups. These characteristics will determine its suitability for drug delivery, diagnostic imaging, and as a genetic material carrier. This review will focus initially on the unique properties of dendrimers and their use in biomedical applications, as antibacterial, antitumor, and diagnostic agents. Subsequently, emphasis will be given to their use in drug delivery for ocular diseases.

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Section: Diagnostic Applicationsmentioning

confidence: 99%

Dendrimers as tunable vectors of drug delivery systems and biomedical and ocular applications

Kalomiraki¹,

Thermos²,

Chaniotakis³

2015

IJN

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“…Literature presents numerous reports on possible methods of using these macromolecules (Bhattacharya et al, 2013), among other things in biology or medicine Gor et al, 2014;Liu et al, 2014;Zhao et al, 2011). Dendrimer macromolecules can fulfil the function of supramolecular nanocarriers of low-molecular ligands: fragments of genetic material (Cao et al, 2013;Eichman et al, 2000;Jang et al, 2009;Pavan et al, 2010a,b;Peng et al, 2010;Shakhbazau et al, 2010;Wang et al, 2010), medical image contrasts (Tomalia et al, 2007) or drugs (Cheng and Xu, 2005;D'Emanuele and Attwood, 2005;Gupta et al, 2006;Kesharwani et al, 2014;Medina and El-Sayed, 2009;Najlah and D'Emanuele, 2006), including oncological drugs Kong et al, 2014;Sadekar et al, 2013;Thomas et al, 2010). Dendrimers can also influence the conformation of protein being of importance for the functioning of protein nervous system (Klajnert et al, 2007;Neelov et al, 2013), reduce the risk of viral infections (Tyssen et al, 2010), including HIV (Date and Destache, 2013;Tyssen et al, 2010;Vacas-Córdoba et al, 2014) and facilitate the permeation of substances through cell membranes (Ainalem et al, 2010;Kelly et al, 2008;Larson, 2006, 2008a,b;Mecke et al, 2004;Tiriveedhi et al, 2011;Voulgarakis et al, 2009) and skin Perumal, 2008, 2009;Yang et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Spectroscopic and calorimetric studies of formation of the supramolecular complexes of PAMAM G5-NH2 and G5-OH dendrimers with 5-fluorouracil in aqueous solution

Buczkowski

Olesiński

Zbicinska

et al. 2015

International Journal of Pharmaceutics

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“…42,43 They can also be used in targeted gene or drug delivery. 17–19,21,44–47 For our purposes, we propose that polyamidoamine (PAMAM) den-drimers, 16,17,19 which are charged nanoparticles, can serve as first model systems to mimic the electrostatic nature of protein-DNA interactions.…”

Section: Introductionmentioning

confidence: 99%

On the Possibility of Facilitated Diffusion of Dendrimers Along DNA

Ficici

Andricioaei

2015

J. Phys. Chem. B

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We investigate the electrostatics, energetics and dynamics of dendrimer-DNA interactions that mimic protein-DNA complexes as means to design facilitated mechanisms by which dendrimers can slide and search DNA for targets. By using all-atom molecular dynamics simulations, we calculated the free energy profiles of dendrimer-binding around the DNA via umbrella sampling. We also calculated electrostatic interaction maps in comparison to proteins, as well as the dynamical changes induced by DNA-dendrimer interactions via NMR-measurable order parameters. Our results show that for dendrimers to go around DNA there is a free energy barrier of 8.5 kcal/mol from the DNA major groove to DNA minor groove, with a minimum in the major groove. This barrier height makes it unlikely for an all-amine dendrimer to slide along DNA longitudinally, but following a helical path may be possible along the major groove. Comparison of the non bonded interaction energy and the interaction free energy profiles reveal a considerable entropic cost as the dendrimer binds to DNA. This is also supported by the mobility patterns obtained from NMR-measurable order parameter values, which show a decreased mobility of the dendrimer N-H bond vectors in the DNA-binding mode.

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Bioinspired application of dendrimers: From bio-mimicry to biomedical applications

Cited by 191 publications

References 145 publications

Dendrimers as tunable vectors of drug delivery systems and biomedical and ocular applications

Dendrimers as tunable vectors of drug delivery systems and biomedical and ocular applications

Spectroscopic and calorimetric studies of formation of the supramolecular complexes of PAMAM G5-NH2 and G5-OH dendrimers with 5-fluorouracil in aqueous solution

On the Possibility of Facilitated Diffusion of Dendrimers Along DNA

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