Bioinspired, Bioactive, and Bactericidal: Anodized Nanotextured Dental Implants

Chopra, Divya; Guo, Tianqi; Jayasree, Anjana; Gulati, Karan; Ivanovski, Sašo

doi:10.1002/adfm.202314031

Cited by 8 publications

(2 citation statements)

References 140 publications

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“…120 In other words, the bacterial membrane cannot be easily stretched and spread on the surface with nanofeatures (eg, nanospears) causing perforation of the bacterial cell. 119,121 For example, Chopra et al have shown that nanopillar-like topographies including spinules, daggers, papillae, spikes, and flame could induce stretching in the bacterial membrane through adhesion forces which led to bacterial cell death. 121 In addition, the spinules and spikes with smaller sharp tips improved the antibacterial efficiency by the application of pressure on the membrane.…”

Section: Topography-mediated Antibacterial Performancementioning

confidence: 99%

“…119,121 For example, Chopra et al have shown that nanopillar-like topographies including spinules, daggers, papillae, spikes, and flame could induce stretching in the bacterial membrane through adhesion forces which led to bacterial cell death. 121 In addition, the spinules and spikes with smaller sharp tips improved the antibacterial efficiency by the application of pressure on the membrane. This finding indicated the key role of the sharpness of nanotopography in antibacterial properties.…”

Section: Topography-mediated Antibacterial Performancementioning

confidence: 99%

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Surface Topography Steer Soft Tissue Response and Antibacterial Function at the Transmucosal Region of Titanium Implant

Safaei,

Mohammadi,

Beddu

et al. 2024

IJN

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Metallic dental implants have been extensively used in clinical practice due to their superior mechanical properties, biocompatibility, and aesthetic outcomes. However, their integration with the surrounding soft tissue at the mucosal region remains challenging and can cause implant failure due to the peri-implant immune microenvironment. The soft tissue integration of dental implants can be ameliorated through different surface modifications. This review discussed and summarized the current knowledge of topography-mediated immune response and topography-mediated antibacterial activity in Ti dental implants which enhance soft tissue integration and their clinical performance. For example, nanopillar-like topographies such as spinules, and spikes showed effective antibacterial activity in human salivary biofilm which was due to the lethal stretching of bacterial membrane between the nanopillars. The key findings of this review were (I) cross-talk between surface nanotopography and soft tissue integration in which the surface nanotopography can guide the perpendicular orientation of collagen fibers into connective tissue which leads to the stability of soft tissue, (II) nanotubular array could shift the macrophage phenotype from pro-inflammatory (M1) to anti-inflammatory (M2) and manipulate the balance of osteogenesis/osteoclasia, and (III) surface nanotopography can provide specific sites for the loading of antibacterial agents and metallic nanoparticles of clinical interest functionalizing the implant surface. Silver-containing nanotubular topography significantly decreased the formation of fibrous encapsulation in per-implant soft tissue and showed synergistic antifungal and antibacterial properties. Although the Ti implants with surface nanotopography have shown promising in targeting soft tissue healing in vitro and in vivo through their immunomodulatory and antibacterial properties, however, long-term in vivo studies need to be conducted particularly in osteoporotic, and diabetic patients to ensure their desired performance with immunomodulatory and antibacterial properties. The optimization of product development is another challenging issue for its clinical translation, as the dental implant with surface nanotopography must endure implantation and operation inside the dental microenvironment. Finally, the sustainable release of metallic nanoparticles could be challenging to reduce cytotoxicity while augmenting the therapeutic effects.

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Section: Topography-mediated Antibacterial Performancementioning

confidence: 99%

Section: Topography-mediated Antibacterial Performancementioning

confidence: 99%

Surface Topography Steer Soft Tissue Response and Antibacterial Function at the Transmucosal Region of Titanium Implant

Safaei,

Mohammadi,

Beddu

et al. 2024

IJN

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Enhancing Antibacterial Properties and Biocompatibility of Titanium Surfaces through Synergy of Plasma Electrolytic Oxidation and Hydrothermal Process

Mazinani,

Nine,

Rastin

et al. 2024

Adv Eng Mater

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Plasma electrolytic oxidation (PEO) is a well‐established electrochemical method to modify titanium (Ti) surfaces for various industrial applications, including automobile, aerospace, nuclear, sports, defense, and biomedical industries. However, PEO surfaces, with their subsequent nanostructural modification to achieve enhanced antibacterial properties, osseointegration, and biocompatibility on biomedical implants are barely explored. This study investigates the combined approach of PEO and hydrothermal (HT) processes to introduce a range of nanostructures on PEO‐induced porous titania for enhanced antibacterial and improved osseointegration properties. Different fabrication conditions of combined PEO and HT process enabled the fabrication of multidimensional nano‐morphologies, such as blades, needles, belts, and grass that exhibit mechano‐bactericidal properties with enhanced biocompatibility. Antibacterial performance shows that nanostructures generated using HT on the acidic PEO process have excellent antibacterial activity, destroying 88% of E. coli and ≈99% of S. aureus colonies after 24 h incubation. All these fabricated structures show very high biomineralization ability, as confirmed by simulated body fluid (SBF) tests. This study provides valuable contributions showing the potential of low‐cost PEO technology combined with other surface engineering methods for scalable modification and improvements of titanium implants with advanced antibacterial and biointegration properties.

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Biomimetic Materials for Antibacterial Applications

Zhang,

Dong,

Liu

et al. 2024

Small

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The rise of antibiotic resistance poses a critical threat to global health, necessitating the development of novel antibacterial strategies to mitigate this growing challenge. Biomimetic materials, inspired by natural biological systems, have emerged as a promising solution in this context. These materials, by mimicking biological entities such as plants, animals, cells, viruses, and enzymes, offer innovative approaches to combat bacterial infections effectively. This review delves into the integration of biomimicry with materials science to develop antibacterial agents that are not only effective but also biocompatible and less likely to induce resistance. The study explores the design and function of various biomimetic antibacterial materials, highlighting their therapeutic potential in anti‐infection applications. Further, the study provides a comprehensive summary of recent advancements in this field, illustrating how these materials have been engineered to enhance their efficacy and safety. The review also discusses the critical challenges facing the transition of these biomimetic strategies from the laboratory to clinical settings, such as scalability, cost‐effectiveness, and long‐term stability. Lastly, the study discusses the vast opportunities that biomimetic materials hold for the future of antibacterial therapy, suggesting that continued research and multidisciplinary collaboration will be essential to realize their full potential.

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Bioinspired, Bioactive, and Bactericidal: Anodized Nanotextured Dental Implants

Cited by 8 publications

References 140 publications

Surface Topography Steer Soft Tissue Response and Antibacterial Function at the Transmucosal Region of Titanium Implant

Surface Topography Steer Soft Tissue Response and Antibacterial Function at the Transmucosal Region of Titanium Implant

Enhancing Antibacterial Properties and Biocompatibility of Titanium Surfaces through Synergy of Plasma Electrolytic Oxidation and Hydrothermal Process

Biomimetic Materials for Antibacterial Applications

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