Bioinspired by cell membranes: functional polymeric materials for biomedical applications

Chen, Xingyu; Li, Jianshu

doi:10.1039/c9qm00717b

Cited by 52 publications

(28 citation statements)

References 255 publications

(359 reference statements)

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“…Using the analogy of a hypothetical biomimetic material we realize that man-made materials still lag far behind its biological counterparts. It is encouraging, however, that this opportunity has been recognized, nucleating a rapidly growing research field ( Amaral and Pasparakis, 2019 ; Chen and Li, 2020 ). Future advancements into bioinspired and biomimetic material will likely benefit from computational approaches ( Sun et al, 2018 ; Schroer et al, 2020 ), which allow rapid advancement of theoretical and experimental data of membrane-MCA-cortex dynamics at an ever-increasing spatio-temporal resolution.…”

Section: Discussionmentioning

confidence: 99%

Cellular Membranes, a Versatile Adaptive Composite Material

Lamparter

Galic

2020

Front. Cell Dev. Biol.

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Cellular membranes belong to the most vital yet least understood biomaterials of live matter. For instance, its biomechanical requirements substantially vary across species and subcellular sites, raising the question how membranes manage to adjust to such dramatic changes. Central to its adaptability at the cell surface is the interplay between the plasma membrane and the adjacent cell cortex, forming an adaptive composite material that dynamically adjusts its mechanical properties. Using a hypothetical composite material, we identify core challenges, and discuss how cellular membranes solved these tasks. We further muse how pathological changes in material properties affect membrane mechanics and cell function, before closing with open questions and future challenges arising when studying cellular membranes.

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Section: Discussionmentioning

confidence: 99%

Cellular Membranes, a Versatile Adaptive Composite Material

Lamparter

Galic

2020

Front. Cell Dev. Biol.

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“…Considering this natural process of the cell membrane fusion as an analogy, their materials’ counterpart [ 65 ] through chemical synthesis can be a promising approach for the formation of nanoscale assembly materials which is also helpful for the understanding of the fusion process at the nanoscale in more detail. Therefore, here, a spontaneous self‐assembling process has been conducted for the case of assembling polymeric nanoparticles during ongoing polymerization which is termed as “continuous self‐assembly” because the assembling has been realized during ongoing continuous polymerization by a single‐step synthesis approach.…”

Section: Continuous Self‐assemblymentioning

confidence: 99%

Hierarchical Assemblies of Polymer Particles through Tailored Interfaces and Controllable Interfacial Interactions

Visaveliya

Köhler

2020

Adv Funct Materials

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Hierarchical assembly architectures of functional polymer particles are promising because of their physicochemical and surface properties for multi‐labeling and sensing to catalysis and biomedical applications. While polymer nanoparticles’ interior is mainly made up of the cross‐linked network, their surface can be tailored with soft, flexible, and responsive molecules and macromolecules as potential support for the controlled particulate assemblies. Molecular surfactants and polyelectrolytes as interfacial agents improve the stability of the nanoparticles whereas swellable and soft shell‐like cross‐linked polymeric layer at the interface can significantly enhance the uptake of guest nano‐constituents during assemblies. Besides, layer‐by‐layer surface‐functionalization holds the ability to provide a high variability in assembly architectures of different interfacial properties. Considering these aspects, various assembly architectures of polymer nanoparticles of tunable size, shapes, morphology, and tailored interfaces together with controllable interfacial interactions are constructed here. The microfluidic‐mediated platform has been used for the synthesis of constituents polymer nanoparticles of various structural and interfacial properties, and their assemblies are conducted in batch or flow conditions. The assemblies presented in this progress report is divided into three main categories: cross‐linked polymeric network's fusion‐based self‐assembly, electrostatic‐driven assemblies, and assembly formed by encapsulating smaller nanoparticles into larger microparticles.

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“…CP-modified surface could not only improve the hydrophilicity of materials but also can promote cell adhesion though the CP-PC interaction. [20][21][22][23][24][25] On the basis of this special interaction, many studies have conjugated CP to copolymer/micelles for drug delivery systems. [16,17] The CP group can enhance cell membrane adhesion of drug delivery system, promote…”

Section: Doi: 101002/mabi202000069mentioning

confidence: 99%

Cell‐Membrane‐Targeted Drug Delivery System Based on Choline‐Phosphate‐Functionalized β‐Cyclodextrin

Feng

Xin

Zhang

et al. 2020

Macromolecular Bioscience

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In this study, a novel cyclodextrin derivative, i.e., zwitterionic choline phosphate (CP)‐functionalized β‐cyclodextrin (CP‐β‐CD) is successfully synthesized by click chemistry reaction. CP‐β‐CD has excellent cell‐membrane‐targeted ability because of the CP group can bind to phosphate choline (PC) in the cell membrane and promote the cellular uptake. Due to the introduction of CP group on β‐CD, it disrupts the hydrogen network between natural β‐CD molecules. Meanwhile, the water solubility of CP‐β‐CD is improved dramatically to 816 mg mL−1, which is 440 times as that of unmodified β‐CD. Apatinib, a small molecular inhibitor, is used as a model of hydrophobic drug and loaded into CP‐β‐CD to study the solubilization effect and the anti‐angiogenisis activity. In addition, the cytotoxicity of CP‐β‐CD is also studied, and it is demonstrated that CP‐β‐CD is nontoxic. These results indicate that the apatinib can be transported into cell interior and play an excellent anti‐angiogenisis activity after being loaded into CP‐β‐CD drug delivery system. This work suggests that the water soluble CP‐β‐CD with excellent cell internalization efficiency has a potential application prospect in the field of drug delivery.

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Bioinspired by cell membranes: functional polymeric materials for biomedical applications

Abstract: This review describes the functional biomedical polymers developed by the biomimetic/bioinspired strategies from various prototypes of cell membranes.

Cited by 52 publications

References 255 publications

Cellular Membranes, a Versatile Adaptive Composite Material

Cellular Membranes, a Versatile Adaptive Composite Material

Hierarchical Assemblies of Polymer Particles through Tailored Interfaces and Controllable Interfacial Interactions

Cell‐Membrane‐Targeted Drug Delivery System Based on Choline‐Phosphate‐Functionalized β‐Cyclodextrin

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