Bioinspired colloidal systems vialayer-by-layer assembly

Angelatos, Alexandra S.; Katagiri, Kiyofumi; Caruso, Frank

doi:10.1039/b511930h

Cited by 137 publications

(116 citation statements)

References 56 publications

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“…A lipid membrane on top of a PEM provides a suitable interface of the artificial polyelectrolyte composite with biological systems, since on one hand it minimizes non-specific interactions and on the other hand it enables the tailoring of the surface with specific interactions through the incorporation of membrane-associated biological functions. [18][19][20] For capsules consisting of polyelectrolyte multilayers, the applications of polyelectrolyte supported lipid layers focus on controlling the permeability of the supporting capsule walls.…”

Section: -17mentioning

confidence: 99%

Lipid layers on polyelectrolyte multilayer supports

et al. 2008

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The mechanism of formation of supported lipid layers from phosphatidylcholine and phosphatidylserine vesicles in solution on polyelectrolyte multilayers was studied by a variety of experimental techniques. The interaction of zwitterionic and acidic lipid vesicles, as well as their mixtures, with polyelectrolyte supports was followed in real time by micro-gravimetry. The fabricated lipid-polyelectrolyte composite structures on top of multilayer coated colloidal particles were characterized by flow cytometry and imaging techniques. Lipid diffusion over the macroscopic scale was quantified by fluorescence recovery after photobleaching, and the diffusion was related to layer connectivity. The phospholipid-polyelectrolyte binding mechanism was investigated by infrared spectroscopy. A strong interaction of polyelectrolyte primary amino groups with phosphate and carboxyl groups of the phospholipids, leading to dehydration, was observed. Long-range electrostatic attraction was proven to be essential for vesicle spreading and rupture. Fusion of lipid patches into a homogeneous bilayer required lateral mobility of the lipids on the polyelectrolyte support. The binding of amino groups to the phosphate group of the zwitterionic lipids was too weak to induce vesicle spreading, but sufficient for strong adsorption. Only the mixture of phosphatidylcholine and phosphatidylserine resulted in the spontaneous formation of bilayers on polyelectrolyte multilayers. The adsorption of phospholipids onto multilayers displaying quarternary ammonium polymers produced a novel 3D lipid polyelectrolyte structure on colloidal particles.

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Section: -17mentioning

confidence: 99%

Lipid layers on polyelectrolyte multilayer supports

et al. 2008

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“…Recently, this technique has been applied for the fabrication of tiny three-dimensional microstructures, called hollow polyelectrolyte capsules, by LbL coating of a sacrificial template followed by the dissolution of this template. [8,9] Due to the multifunctionality of the LbL technique, it is possible to fabricate tailor-made capsules with functionalized [10,11] or stimuli-responsive [12,13] walls which could be promising for drug-delivery applications. [14,15] Nanoparticle-containing capsules have already been reported in literature, although in all cases the number of nanoparticle layers was limited to one [16] or the nanoparticles were introduced (e.g., by synthesis within the capsule wall) after the fabrication of the capsules.…”

Section: Introductionmentioning

confidence: 99%

Stimuli‐Responsive Multilayered Hybrid Nanoparticle/Polyelectrolyte Capsules

Geest

Skirtach

Beer

et al. 2007

Macromol. Rapid Commun.

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Gold nanoparticles (AuNP) with carboxyl groups on their surface were used in combination with PAH for the layer‐by‐layer coating of CaCO3 microparticles, followed by the dissolution of the CaCO3 core. SEM, TEM, and confocal microscopy are used to characterize the hybrid nanoparticles/polyelectrolyte capsules. As the AuNP have carboxyl groups on their surface, their charge density is pH dependent; therefore, the capsules exhibit a pH‐dependent swelling and can be deconstructed both at low and high pH. By covalent cross‐linking of the carboxyl groups of the AuNP and the amino groups of the PAH, it is possible to suppress the pH‐responsive behavior. AuNP are used as activation centers using IR light and this ability is used to release encapsulated material from the nanoparticles/polyelectrolyte capsules as well as for the enhancement of detection and imaging of such capsules by Raman microspectrosopy.magnified image

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“…Thus, core-shell designed nanoparticles, specifically, are considered advanced nanostructures offering superior advantages over traditional nanomaterials, giving significance and need for their use [20][21][22][23]. Caruso and group have previously highlighted the feasibility and potential of the L-b-L technique in formulating novel particles and modifying basic polymeric bio-inspired colloidal systems [23].…”

Section: Bio-functionalized Core-shell Designed Nanomaterials and Nanmentioning

confidence: 99%

“…A simple, well-known and highly-adaptable method is the layer-by-layer (L-b-L) self-assembly technique [20]. By dictating and controlling the type, composition, number and thickness of alternating layers surrounding the core, multi-functional core-shell nanostructures of various MW can be formulated where both, magnetic and luminescent layers can be combined to detect and manipulate the particles in situ [23]. Thus, core-shell designed nanoparticles, specifically, are considered advanced nanostructures offering superior advantages over traditional nanomaterials, giving significance and need for their use [20][21][22][23].…”

Section: Bio-functionalized Core-shell Designed Nanomaterials and Nanmentioning

confidence: 99%

“…By dictating and controlling the type, composition, number and thickness of alternating layers surrounding the core, multi-functional core-shell nanostructures of various MW can be formulated where both, magnetic and luminescent layers can be combined to detect and manipulate the particles in situ [23]. Thus, core-shell designed nanoparticles, specifically, are considered advanced nanostructures offering superior advantages over traditional nanomaterials, giving significance and need for their use [20][21][22][23]. Caruso and group have previously highlighted the feasibility and potential of the L-b-L technique in formulating novel particles and modifying basic polymeric bio-inspired colloidal systems [23].…”

Section: Bio-functionalized Core-shell Designed Nanomaterials and Nanmentioning

confidence: 99%

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Bio-Inspired/-Functional Colloidal Core-Shell Polymeric-Based NanoSystems: Technology Promise in Tissue Engineering, Bioimaging and NanoMedicine

Haidar

2010

Polymers

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Abstract:Modern breakthroughs in the fields of proteomics and DNA micro-arrays have widened the horizons of nanotechnology for applications with peptides and nucleic acids. Hence, biomimetic interest in the study and formulation of nanoscaled bio-structures, -materials, -devices and -therapeutic agent delivery vehicles has been recently increasing. Many of the currently-investigated functionalized bio-nanosystems draw their inspiration from naturally-occurring phenomenon, prompting the integration of molecular signals and mimicking natural processes, at the cell, tissue and organ levels. Technologically, the ability to obtain spherical nanostructures exhibiting combinations of several properties that neither individual material possesses on its own renders colloidal core-shell architectured nanosystems particularly attractive. The three main developments presently foreseen in the nanomedicine sub-arena of nanobiotechnology are: sensorization (biosensors/ biodetection), diagnosis (biomarkers/bioimaging) and drug, protein or gene delivery (systemic vs. localized/targeted controlled-release systems). Advances in bio-applications such as cell-labelling/cell membrane modelling, agent delivery and targeting, tissue engineering, organ regeneration, nanoncology and immunoassay strategies, along the major limitations and potential future and advances are highlighted in this review. Herein, is an attempt to address some of the most recent works focusing on bio-inspired and -functional polymeric-based core-shell nanoparticulate systems aimed for agent OPEN ACCESSPolymers 2010, 2 324 324 delivery. It is founded, mostly, on specialized research and review articles that have emerged during the last ten years.Keywords: tissue engineering; quantum dots; drug delivery; dentistry; core-shell; liposomes; polymer; PLLA; biomedicine; nanoncology; nanofibers; bioimaging; biomimetic; biosensors; bone regeneration; glucose; nanoshell; artificial virus; amphiphilic co-polymers; ligand; micelles Abbreviations AL= alginate; BMP-7/OP-1 = bone morphogenetic protein -7/Osteogenic protein-1; CdSe = cadmium selenide; ZnS = zinc sulfide; CH = chitosan; GOD = glucose oxidase; HA = hyaluronic acid; IgG = Immunoglobulin G; L = liposome; L-b-L = layer-by-layer self-assembly technique; MPS = mononuclear phagocyte system; MRI = magnetic resonance imaging; MW = molecular weight; nIR = near infra-red; NZW = New Zealand White; PAC = poly aluminum chloride (cationic); PCL = poly(ε-caprolactone); PEG = polyethylene glycol; PEO = polyethylene oxide; PGA = polyglycolic acid; PLA = polylactic acid; PLGA = poly(lactic-co-glycolic acid); PLLA = poly(l-lactide); PVA = poly (vinyl alcohol); PVP = polyvinylpyrrolidone; QDs = Quantum Dots; RES = reticulo-endothelial system; rh = recombinant human.

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Bioinspired colloidal systems vialayer-by-layer assembly

Cited by 137 publications

References 56 publications

Lipid layers on polyelectrolyte multilayer supports

Lipid layers on polyelectrolyte multilayer supports

Stimuli‐Responsive Multilayered Hybrid Nanoparticle/Polyelectrolyte Capsules

Bio-Inspired/-Functional Colloidal Core-Shell Polymeric-Based NanoSystems: Technology Promise in Tissue Engineering, Bioimaging and NanoMedicine

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