Bioinspired composite packed in blunt needles, integrated microextraction and determination of oxycodone and naloxone in saliva by substrate spray mass spectrometry

Millán-Santiago, Jaime; Lucena, Rafael; Cárdenas, Soledad

doi:10.1016/j.aca.2024.342376

Cited by 3 publications

(2 citation statements)

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“…10 In solid-phase microextraction, the substrate integrates the isolation and analysis steps. Different solid substrates have been proposed for this integration, including paper, 11 wooden tips, 12−14 needles, 15,16 tapes, 17,18 or coated blades. 19,20 As SSI measurements are typically fast, the analysis time in microextraction-SSI couplings mainly depends on the sample preparation step.…”

Section: ■ Introductionmentioning

confidence: 99%

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Coupling Miniaturized Stir Bar Sorptive Dispersive Microextraction to Needle-Based Electrospray Ionization Emitters for Mass Spectrometry: Determination of Tetrahydrocannabinol in Human Saliva as a Proof of Concept

López-Juan,

Millán-Santiago,

Benedé

et al. 2024

Anal. Chem.

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Direct coupling of sample preparation with mass spectrometry (MS) can speed up analysis, enabling faster decision-making. In such combinations, where the analysis time is mainly defined by the extraction procedure, magnetic dispersive solid-phase extraction emerges as a relevant technique because of its rapid workflow. The dispersion and retrieval of the magnetic sorbent are typically uncoupled stages, thus reducing the potential simplicity. Stir bar sorptive dispersive microextraction (SBSDME) is a novel technique that integrates both stages into a single device. Its miniaturization (mSBSDME) makes it more portable and compatible with low-availability samples. This article reports the direct combination of mSBSDME and MS using a needle-based electrospray ionization (NESI) emitter as the interface. This combination is applied to determine tetrahydrocannabinol in saliva samples, a relevant societal problem if the global consumption rates of cannabis are considered. The coupling requires only the transference of the magnet (containing the sorbent and the isolated analyte) from the mSBSDME to the hub of a hypodermic needle, where the online elution occurs. The application of 5 kV on the needle forms an electrospray on its tip, transferring the ionized analyte to the MS inlet. The excellent performance of mSBSDME-NESI-MS/MS relies on the sensitivity (limits of detection as low as 2.25 ng mL–1), the precision (relative standard deviation lower than 15%), and the accuracy (relative recoveries ranged from 87 to 127%) obtained. According to the results, the mSBSDME-NESI-MS/MS technique promises faster and more efficient chemical analysis in MS-based applications.

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Section: ■ Introductionmentioning

confidence: 99%

“…In solid-phase microextraction, the substrate integrates the isolation and analysis steps. Different solid substrates have been proposed for this integration, including paper, wooden tips, − needles, , tapes, , or coated blades. , …”

Section: Introductionmentioning

confidence: 99%