Bioinspired copper single‐atom nanozyme as a superoxide dismutase‐like antioxidant for sepsis treatment

Yang, Ji; Zhang, Ruofei; Zhao, Hanqing; Qi, Haifeng; Li, Jingyun; Li, Jian‐Feng; Zhou, Xinyao; Wang, Aiqin; Fan, Kelong; Yan, Xiyun; Zhang, Tao

doi:10.1002/exp.20210267

Cited by 142 publications

(84 citation statements)

References 68 publications

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“…Nanozyme is also another area of interest that is gaining popularity in recent years due to its unique enzyme-mimetic activities that serve as a highly versatile candidate for many disease therapy (Zhang et al, 2021;Ren et al, 2022). For example, the nanozyme developed by Yang et al display promising results for the treatment of sepsis (Yang et al, 2022). Surface modifications of nanozyme were also shown to provide antitumor properties (Tang et al, 2021).…”

Section: Future Perspectives For Np Designmentioning

confidence: 99%

Design principles of bioinspired interfaces for biomedical applications in therapeutics and imaging

et al. 2022

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In the past two decades, we have witnessed rapid developments in nanotechnology, especially in biomedical applications such as drug delivery, biosensing, and bioimaging. The most commonly used nanomaterials in biomedical applications are nanoparticles, which serve as carriers for various therapeutic and contrast reagents. Since nanomaterials are in direct contact with biological samples, biocompatibility is one of the most important issues for the fabrication and synthesis of nanomaterials for biomedical applications. To achieve specific recognition of biomolecules for targeted delivery and biomolecular sensing, it is common practice to engineer the surfaces of nanomaterials with recognition moieties. This mini-review summarizes different approaches for engineering the interfaces of nanomaterials to improve their biocompatibility and specific recognition properties. We also focus on design strategies that mimic biological systems such as cell membranes of red blood cells, leukocytes, platelets, cancer cells, and bacteria.

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Section: Future Perspectives For Np Designmentioning

confidence: 99%

Design principles of bioinspired interfaces for biomedical applications in therapeutics and imaging

et al. 2022

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“…Researchers have attempted to intervene sepsis by targeting specific proinflammatory mediators, such as counteracting the burst of ROS with nanozymes [19][20][21]. Many nanozymes have been found to exhibit excellent antioxidant capacity, either by themselves or after surface modification [22][23][24][25]. They have shown significant ROS scavenging capacity in the treatment of proinflammatory sepsis [26,27].…”

Section: Introductionmentioning

confidence: 99%

Decoy Nanozymes Enable Multitarget Blockade of Proinflammatory Cascades for the Treatment of Multi-Drug-Resistant Bacterial Sepsis

Zhang

Zhou

et al. 2022

Research

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Sepsis is a life-threatening organ dysfunction characterized by severe systemic inflammatory response to infection. Effective treatment of bacterial sepsis remains a paramount clinical challenge, due to its astonishingly rapid progression and the prevalence of bacterial drug resistance. Here, we present a decoy nanozyme-enabled intervention strategy for multitarget blockade of proinflammatory cascades to treat multi-drug-resistant (MDR) bacterial sepsis. The decoy nanozymes (named MCeC@MΦ) consist mesoporous silica nanoparticle cores loaded with CeO2 nanocatalyst and Ce6 photosensitizer and biomimetic shells of macrophage membrane. By acting as macrophage decoys, MCeC@MΦ allow targeted photodynamic eradication of MDR bacteria and realize simultaneous endotoxin/proinflammatory cytokine neutralization. Meanwhile, MCeC@MΦ possess intriguing superoxide dismutase and catalase-like activities as well as hydroxyl radical antioxidant capacity and enable catalytic scavenging of multiple reactive oxygen species (ROS). These unique capabilities make MCeC@MΦ to collaboratively address the issues of bacterial infection, endotoxin/proinflammatory cytokine secretion, and ROS burst, fully cutting off the path of proinflammatory cascades to reverse the progression of bacterial sepsis. In vivo experiments demonstrate that MCeC@MΦ considerably attenuate systemic hyperinflammation and rapidly rescue organ damage within 1 day to confer higher survival rates (>75%) to mice with progressive MDR Escherichia coli bacteremia. The proposed decoy nanozyme-enabled multitarget collaborative intervention strategy offers a powerful modality for bacterial sepsis management and opens up possibilities for the treatment of cytokine storm in the COVID-19 pandemic and immune-mediated inflammation diseases.

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“…Moreover, nanomaterials with enzyme-like activity, widely termed as nanozymes, have also inspired the extended direction of EBFCs, based on their superior characteristics compared to natural enzymes, such as long-term stability and robustness for extended lifetime, facile scale-up synthesis with low cost, and high and tunable enzyme-like activities enabling sufficient power output . Nanozymes have been extensively studied as a replacement to natural enzymes in biosensor, biomedicine, bioimaging, and environmental remediation; and in the bioenergetic engineering area, they have been recognized promising enzyme-like material to enhance the power-generating performance of EBFCs. − …”

Section: Introductionmentioning

confidence: 99%

Tailoring Nanostructured Supports to Achieve High Performance in Enzymatic Biofuel Cells

Kong

et al. 2022

ACS Appl. Energy Mater.

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Enzymatic biofuel cells (EBFCs) are attractive power sources capable of utilizing biomolecules to generate electrical power. However, their practical utility is limited because of their relatively low power output and short lifetime, which arise from the low enzyme loading capacity on the support materials, activity loss during enzyme immobilization, intrinsically poor enzyme stability, and limited substrate and electron transport. Nanobiocatalytic approaches, in which enzymes are incorporated with nanostructured supports, have been recognized as a potent solution to resolve these limitations. They construct high-performance enzyme electrodes utilizing the affirmative characteristics of the materials coupled with appropriate immobilization strategies. In this review, the roles of nanostructured supports and catalytic mechanisms for generating biofuel-driven electrical power, the recent research progress on EBFCs based on widely investigated nanocarbons, nanoparticles, and polymeric nanofibers, and newly emerged metal–organic frameworks, nanoflowers, and other nanohybrids are discussed. The current challenges and prospects for utilizing nanostructured supports in EBFCs are also discussed.

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Bioinspired copper single‐atom nanozyme as a superoxide dismutase‐like antioxidant for sepsis treatment

Cited by 142 publications

References 68 publications

Design principles of bioinspired interfaces for biomedical applications in therapeutics and imaging

Design principles of bioinspired interfaces for biomedical applications in therapeutics and imaging

Decoy Nanozymes Enable Multitarget Blockade of Proinflammatory Cascades for the Treatment of Multi-Drug-Resistant Bacterial Sepsis

Tailoring Nanostructured Supports to Achieve High Performance in Enzymatic Biofuel Cells

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