Origami-inspired mechanisms possess a diverse range of strengths, including tunable mechanical properties, transforming geometries, and their ease of manufacturing. Many of these qualities have been formalized into mathematical and physics-based models, and have been applied in space deployment, microscale manufacturing, computational fabrication, and other areas of interest. This makes origami engineering a promising approach for mechanism transformation; however, building machines using these principles and controlling their performance is difficult due to inherent limitations in their mechanical design. This thesis presents models and physical experiments to demonstrate the following improvements to origami engineering: (1) speeding up transformations to less than one second; (2) solving actuation difficulties, increasing transformation efficiency, and achieving reliable and predictable origami transformations; and (3) increasing self-folding origami machines' sizes to meter-scale while retaining their load-bearing capabilities. In total, these advances can be used to improve the robustness and functionality of origami machines. Given that origami can replicate almost any shape, we expect that this framework will be applicable for the transformation of arbitrary structures and mechanisms.