Bioinspired fabrication of high strength hydrogels from non-covalent interactions

Wang, Wei; Zhang, Yinyu; Liu, Wenguang

doi:10.1016/j.progpolymsci.2017.04.001

Cited by 416 publications

(195 citation statements)

References 185 publications

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“…This increase in mechanical properties of the patches may be due to the electrostatic interactions between the positively charged groups in Bio-IL and the negatively charged functional groups present in the GelMA polymer. Ionic interactions, such as these, have previously been shown to increase mechanical strength in hydrogels [48]. In addition, there might be chemical bonding between the Bio-IL and GelMA prepolymer through photopolymerization, which can also increase the mechanical properties of the patches.…”

Section: Mechanical Characterization Of Gelma/bio-il Cardiopatchesmentioning

confidence: 99%

Engineering a naturally-derived adhesive and conductive cardiopatch

et al. 2019

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Myocardial infarction (MI) leads to a multi-phase reparative process at the site of damaged heart that ultimately results in the formation of non-conductive fibrous scar tissue. Despite the widespread use of electroconductive biomaterials to increase the physiological relevance of bioengineered cardiac tissues in vitro, there are still several limitations associated with engineering biocompatible scaffolds with appropriate mechanical properties and electroconductivity for cardiac tissue regeneration. Here, we introduce highly adhesive fibrous scaffolds engineered by electrospinning of gelatin methacryloyl (GelMA) followed by the conjugation of a choline-based bio-ionic liquid (Bio-IL) to develop conductive and adhesive cardiopatches. These GelMA/Bio-IL adhesive patches were optimized to exhibit mechanical and conductive properties similar to the native myocardium. Furthermore, the engineered patches strongly adhered to murine myocardium due to the formation of ionic bonding between the Bio-IL and native tissue, eliminating the need for suturing. Co-cultures of primary cardiomyocytes and cardiac fibroblasts grown on GelMA/Bio-IL patches exhibited comparatively better contractile profiles compared to pristine GelMA controls, as demonstrated by over-expression of the gap junction protein connexin 43. These cardiopatches could be used to provide mechanical support and restore electromechanical coupling at the site of MI to minimize cardiac remodeling and preserve normal cardiac function.

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Section: Mechanical Characterization Of Gelma/bio-il Cardiopatchesmentioning

confidence: 99%

Engineering a naturally-derived adhesive and conductive cardiopatch

et al. 2019

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“…Various tough hydrogels have been developed, associating with different mechanism and design strategy . However, toward tissue engineering, the application of most currently practiced tough hydrogels are limited.…”

Section: Discussionmentioning

confidence: 99%

“…Various tough hydrogels have been developed, associating with different mechanism and design strategy. 9,27 However, toward tissue engineering, the application of most currently practiced tough hydrogels are limited. Because many tough hydrogels are often designed based on non-degradable polymers, such as polyacrylic acid derivatives.…”

Section: Discussionmentioning

confidence: 99%

Dextran‐based hydrogel with enhanced mechanical performance via covalent and non‐covalent cross‐linking units carrying adipose‐derived stem cells toward vascularized bone tissue engineering

Cai

Quan

et al. 2019

J Biomedical Materials Res

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Hydrogels for biomedical applications were limited toward bone tissue engineering due to the poor mechanical performance. Tough hydrogels with strong and elastic features have received extensive attention, the application of which, however, was limited by their degradation. The present study introduced an approach to enhance mechanical properties of hydrogel while ensuring its degradation. Carboxyl dextran (Dex) was grafting modified by poly (ε‐caprolactone) (PCL), sequentially followed by being cross‐linked through polyethyleneglycol 400 (PEG400) to yield a gel with covalent cross‐linking units in DMSO. The gel was underwent solvent displacement in H2O to induce hydrophobic association of PCL to form non‐covalent cross‐linking units. The tough Dex‐g‐PCL hydrogel showed maximum strain of Dex‐g‐PCL hydrogel was 90% ± 6%, with the corresponding stress of 2.7 ± 0.2 MPa, which was significantly enhanced when comparing to dextran hydrogel (maximum strain 65% ± 5%, with the corresponding stress of 0.225 ± 0.06 MPa). Most hydrogel degraded after 12 w in vivo with only a little residues. Adipose‐derived stem cells (ASCs) proliferated well after being seeded in hydrogel to form micro‐mass at 14 days post‐seeding. In vitro and in vivo angiogenesis, as well as in vitro osteogenesis illustrated the potential of the Dex‐g‐PCL hydrogel carrying ASCs toward vascularized bone tissue engineering. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 1120–1131, 2019.

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“…At present, hydrogels used in deformation studies are relativelyw eak and cannotm eet the needs of practical applications. However,i n recent years, high-strength hydrogels have been rapidlyd eveloped, [92][93][94] which should be considered for the construction of patterned hydrogels with improved mechanical strength and controllable deformation. Second, new actuating means, especially the remote ones, should be developed to trigger the deformations.…”

Section: Discussionmentioning

confidence: 99%

Photolithographically Patterned Hydrogels with Programmed Deformations

Hao

et al. 2018

Chemistry An Asian Journal

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Programmed deformations are widespread in nature, providinge legantp aradigms to design self-morphing materials with promising applications in biomedical devices, flexible electronics, soft robotics, etc. In this emerging field, hydrogels are an ideal materialt oi nvestigate the deformation principle and the structure-deformation relationship. One crucial step is to construct heterogeneouss tructures in af acile yet effective way.H erein, we provide af ocus review on different deformation modes and corresponding structural features of hydrogels. Photolithography is av ersatile approach to control the outer shape of the hydrogel and spatiald istribution of the component in the hydrogel, endowing the patterned hydrogels with programmed internal stress and thus controllable deformations. Specifically, cooperative deformations take place in periodically patterned hydrogelsw ith in-plane gradients, and multiple morphing structures are formed in one patternedh ydrogel using selective preswelling to directt he buckling of each unit. The structuralc ontrol strategy and deformation principles should be applicable to other materials with broad applications in diverseareas.

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Bioinspired fabrication of high strength hydrogels from non-covalent interactions

Cited by 416 publications

References 185 publications

Engineering a naturally-derived adhesive and conductive cardiopatch

Engineering a naturally-derived adhesive and conductive cardiopatch

Dextran‐based hydrogel with enhanced mechanical performance via covalent and non‐covalent cross‐linking units carrying adipose‐derived stem cells toward vascularized bone tissue engineering

Photolithographically Patterned Hydrogels with Programmed Deformations

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