Bioinspired Flexible and Tough Layered Peptide Crystals

Adler‐Abramovich, Lihi; Arnon, Zohar A.; Sui, XiaoMeng; Azuri, Ido; Cohen, Hadar; Hod, Oded; Kronik, Leeor; Shimon, Linda J. W.; Wagner, H. Daniel; Gazit, Ehud

doi:10.1002/adma.201704551

Cited by 35 publications

(35 citation statements)

References 33 publications

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“…Before actuating properties of TS crystals can be explored as a platform for conversion of thermal energy to mechanical work, the range of their basic performance capabilities must be established based on commonly accepted performance indices. With exception of several special cases of organic materials with unusually high Young's moduli, organic crystals are generally known to be soft in nature, particularly when compared to metals and alloys. A large contribution to the mechanical properties of organic crystals is governed by intermolecular interactions, which are considerably weaker than the intramolecular (covalent) or metallic bonds.…”

Section: Discussionmentioning

confidence: 99%

Global Performance Indices for Dynamic Crystals as Organic Thermal Actuators

Karothu

Halabi

et al. 2020

Advanced Materials

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same basic thermodynamic principles of energy transduction and are collectively referred to as actuators. [1][2][3][4][5][6][7][8][9][10] While complex natural biomechanical systems have evolved to aid functions such as dispersal and survival, the artificially manufactured actuators are specifically designed for integration in mechatronic or adaptronic systems that range from miniature devices such as navigation and positioning systems in flying machines, to complex systems that can perform tasks in specific environments, such as humanoid robots and spacecraft. The current applications of actuators are many and diverse; they include sensors, [11,12] artificial muscles, [13] soft robotics, [14] and energy-harvesting materials. [15] Simple or complex actuating motions can be induced by heat, light, electricity, pressure, and moisture, among other stimuli, and can be realized with shape-memory polymers, [16] conductive fibers, [17] liquid crystal elastomers, [18] piezoelectric, [19] magnetostrictive, [20] and electromagnetic materials. [21] The energy supplied to the artificial actuators can vary from fluid pressure or flow in the pneumatics, to current, charge or voltage in the electromagnetic, piezoelectric and magnetostrictive actuators, to heat in shape memory and thermal expansion actuators.The active media in actuators include fluids, hard solids such as metals, and even complex soft matter such as tissuesensembles of cells with similar structure that act together to perform a specific function. While molecular crystals do not immediately appeal as working actuating medium, their dynamic properties have recently transpired as an alternative to other materials and they are thought to hold an untapped potential for miniature, soft actuating devices, quickly shaping up into a new research field, crystal adaptronics. [22,23] Smallscale demonstrations of the usefulness of molecular crystals as microscale devices, including cantilevers, [24,25] ratchets, [26] optical waveguides, [27][28][29][30][31][32][33][34][35][36] and other "crystal gears" [37] that can move or reshape are occasionally reported for dynamic crystals. Although being very illustrative, these demonstrations have thus far remained limited to a laboratory scale and have not been implemented in actual, functional devices. Some of the obstacles toward wider applications are difficulties with reproducible growth of crystals of predictable size without the use Crystal adaptronics is an emergent materials science discipline at the intersection of solid-state chemistry and mechanical engineering that explores the dynamic nature of mechanically reconfigurable, motile, and explosive crystals. Adaptive molecular crystals bring to materials science a qualitatively new set of properties that associate long-range structural order with softness and mechanical compliance. However, the full potential of this class of materials remains underexplored and they have not been considered as materials of choice in an engineer's toolbox. A set of general performance metric...

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Section: Discussionmentioning

confidence: 99%

Global Performance Indices for Dynamic Crystals as Organic Thermal Actuators

Karothu

Halabi

et al. 2020

Advanced Materials

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“…The dosage-dependent MTT experiments showed that the cellular viabilities are all higher than 95%, even for the highest concentrations, implying that the nanobelts are not toxic and biocompatible to living organisms (Figure 6a). It can be accounted for the flexibility endowed by the laminated organization of the nanobelts, 45 which makes them deformable when interacting with the cells. Based on this positive result, we conducted the polarized imaging experiments in MCF-7 cells.…”

Section: Resultsmentioning

confidence: 99%

Crystalline Dipeptide Nanobelts Based on Solid–Solid Phase Transformation Self-Assembly and Their Polarization Imaging of Cells

Song

Xing

Jiao

et al. 2018

ACS Appl. Mater. Interfaces

103

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Controlled phase transformation involving biomolecular organization to generate dynamic biomimetic selfassembly systems and functional materials is currently an appealing topic of research on molecular materials. Herein, we achieve by ultrasonic irradiation the direct solid−solid transition of bioinspired dipeptide organization from triclinic structured aggregates to nanofibers and eventually to monoclinic nanobelts with strong polarized luminescence. It is suggested that the locally high temperature and pressure produced by cavitation effects cleaves the hydrophobic, π−π stacking or self-locked intramolecular interactions involved in one phase state and then rearranges the molecular packing to form another well-ordered aromatic dipeptide crystalline structure. Such a sonication-modulated solid−solid phase transition evolution is governed by distinct molecular interactions at different stages of structural organization. The resulting crystalline nanobelts are for the first time applied for polarization imaging of cells, which can be advantageous to directly inspect the uptake and fate of nanoscale delivery platforms without labeling of fluorescent dyes. This finding provides a new perspective to comprehend the dynamic evolution of biomolecular self-organization with energy supply by an external field and open up a facile and versatile approach of using anisotropic nanostructures for polarization imaging of cells and even live organisms in future.

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“…The large aspect ratio of those nanostructures implied that the growth kinetics preferred the axial direction. 35 The assemblies were examined further by powder X-ray diffraction (XRD). The diffraction peaks appeared at 5.8°, 11.2°, 17.1°, and 20.5°for 1-S assemblies (Figure 3d) and at 5.2°, 8.0°, 10.5°, 15.7°, and 26.3°for 2-R assemblies (Figure 3f), which could be attributable to the lattice spacing of the assemblies.…”

Section: -R 2-r and 3-r Showed Visible Suspended Solids Under An mentioning

confidence: 99%

Self-Assembly of Constrained Cyclic Peptides Controlled by Ring Size

Xiong

Sun

et al. 2020

CCS Chem

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The de novo design of new peptide assemblies that expands the repertoire of biomaterial nanostructures has been of a tremendous challenge. Hence, it is evident that a successful research achievement in this area would increase the understanding of molecular interactions in supramolecules and create novel scaffolds exploitable in biotechnology and synthetic biology. The manipulation of cyclic peptide self-assembly is particularly intriguing for this purpose. Herein, we report that a novel type of cyclic peptides, referred to as chiral tether constrained cyclic peptides (CCP), shows promising self-assembly properties. CCPs are the first example of a controllable assembly of all-L-α-cyclic peptides with different ring sizes. A noteworthy feature of the CCP system is good tolerance of different secondary structures, ring size, and peptide sequence. Based on this system, a variety of nanostructures could be constructed, which display different physical properties, rendering it an excellent platform for molecular interaction studies. Further, demonstrate potential applications of these peptide assemblies in bioimaging and energy storage.

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Bioinspired Flexible and Tough Layered Peptide Crystals

Cited by 35 publications

References 33 publications

Global Performance Indices for Dynamic Crystals as Organic Thermal Actuators

Global Performance Indices for Dynamic Crystals as Organic Thermal Actuators

Crystalline Dipeptide Nanobelts Based on Solid–Solid Phase Transformation Self-Assembly and Their Polarization Imaging of Cells

Self-Assembly of Constrained Cyclic Peptides Controlled by Ring Size

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