Bioinspired green deep eutectic solvents: preparation, catalytic activity, and biocompatibility

Joarder, Shaina; Bansal, Divyam; Meena, Harshvardhan; Kaushik, Neha; Tomar, Jaya; Kumari, Kamlesh; Bahadur, Indra; Choi, Eun Ha; Kaushik, Nagendra Kumar; Singh, Prashant

doi:10.1016/j.molliq.2023.121355

Cited by 24 publications

(9 citation statements)

References 105 publications

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“…Specifically, the biocompatibility of choline chloride has been assessed. [50,51] Although not all DESs are readily biodegradable, [52] high rates of biodegradation of choline chloride-based DESs have also been previously confirmed. [53,54] The use of choline chloride and sugars in DES also promotes the green principle of using safer solvents and auxiliaries; (eco)toxicity has also been studied before.…”

Section: Introductionmentioning

confidence: 83%

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Solubility and Stability of Carvedilol in Deep Eutectic Solvents: A Step Towards a Sustainable Pharmaceutical Formulation in the Liquid State

Lomba,

Polo,

Martínez

et al. 2024

ChemistrySelect

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Carvedilol is used to treat chronic hypertension, chronic stable angina pectoris and concomitant treatment heart failure and class II of the Biopharmaceutics Classification System (low solubility and poor bioavailability). This drug is only formulated as tablets, and liquid oral formulations are not available on the market. In this work, several aqueous eutectic mixtures formed by xylitol, citric acid, sorbitol and glucose (HBD) and choline chloride as HBA have been used to improve the solubility. Additionally, SwissADME was used to obtain physicochemical and pharmacokinetic parameters to further knowledge on the ADME (absorption, distribution, metabolism and excretion) parameters for carvedilol.The results reveal that the solubility of carvedilol increases as the content of water decreases, and the mixture formed by citric acid and choline chloride (CACh10) was the most soluble. The stability study shows that carvedilol in DES is stable during the test time, as the maximum and minimum concentration losses were 19.0 % and 0.2 %, respectively. These results help advance the green and sustainable development of new medicines in the liquid state.

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Section: Introductionmentioning

confidence: 83%

“…The chemicals forming the DESs used in this work are biocompatible. Specifically, the biocompatibility of choline chloride has been assessed [50,51] . Although not all DESs are readily biodegradable, [52] high rates of biodegradation of choline chloride‐based DESs have also been previously confirmed [53,54] .…”

Section: Introductionmentioning

confidence: 99%

Solubility and Stability of Carvedilol in Deep Eutectic Solvents: A Step Towards a Sustainable Pharmaceutical Formulation in the Liquid State

Lomba,

Polo,

Martínez

et al. 2024

ChemistrySelect

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show abstract

“…A high DES concentration may also lead to high osmotic pressure in microbial cells, leading to dehydration, and lower cell viability. 272,273 On the other hand, in type V DESs, which are composed of hydrophobic molecular compounds such as terpenes and fatty acids, and normally afford antimicrobial activity, the mechanism of action seems different. Gram-negative bacteria, due to the presence of lipopolysaccharides on the cell wall, avoid fatty acids from reaching cell membrane, while the cell wall of Gram-positive bacteria readily absorbs fatty acids allowing their passage into the inner membrane, causing a destabilization or dissolution.…”

Section: Integration Of Process Steps For Pet Upcyclingmentioning

confidence: 99%

“…It is worth to mention that these toxicity experiments also face other experimental difficulties, such as the high viscosity of DESs, which limits the precision of application of the same quantity of sample, the possible disruption of the DES in aqueous solutions and the diffusion of hydrophobic DES in agar medium-based techniques. 272,273,275,276 These toxicity assays can also be useful to screen IL-and DES-tolerant microorganisms or induce their tolerance using growth in liquid cultures, direct plating or phenotypic microarrays. The molecular mechanisms involved in resistance have pointed towards the active role of compatible solutes ( proline, betaine and choline, for example), enhanced activity of stressinduced enzymes ( peroxidase, catalase and superoxide dismutase), expression of porins or regulatory efflux pumps, adaptation in the fatty acid profile to maintain membrane homeostasis as the generic protective mechanism against IL toxicity.…”

Section: Integration Of Process Steps For Pet Upcyclingmentioning

confidence: 99%

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From trash to cash: current strategies for bio-upcycling of recaptured monomeric building blocks from poly(ethylene terephthalate) (PET) waste

Carniel,

Ferreira dos Santos,

Buarque

et al. 2024

Green Chem.

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Utilization of Cobalt and its Oxide/Hydroxide Mediated by Ionic Liquids/Deep Eutectic Solvents as Catalysts in Water Splitting

Zhang,

Wang,

Jin

et al. 2024

ChemistryOpen

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With the ever‐growing global demand for sustainable energy solutions, hydrogen has garnered significant attention as a clean, efficient, and renewable energy source. In the field of hydrogen production, catalyst research stands out as one of the foremost areas of focus. In recent years, the preparation of electrocatalysts using ionic liquids (ILs) and deep eutectic solvents (DESs) has attracted widespread attention. ILs and DESs possess unique physicochemical properties and are recognized as green media as well as functional materials. Cobalt‐based catalysts have proven to be efficient electrocatalysts for water splitting. Incorporating ILs or DESs into the preparation of cobalt‐based catalysts offers a remarkable advantage by allowing precise control over their structural design and composition. This control directly influences the adsorption properties of the catalyst's surface and the stability of reaction intermediates, thereby enabling enhanced control over reaction pathways and product selectivity. Consequently, the catalytic activity and stability of cobalt‐based catalysts can be effectively improved. In the process of preparing cobalt‐based catalysts, ILs and DESs can serve as solvents and templates. Owing to the good solubility of ILs and DESs, they can efficiently dissolve raw materials and provide a special nucleation and growth environment, obtaining catalysts with novel‐structures. The main focus of this review is to provide a detailed introduction to metal cobalt and its oxide/hydroxide derivatives in the field of water splitting, with a particular emphasis on the research progress achieved through the utilization of IL and DES. The aim is to assist readers in designing and synthesizing novel and high‐performance electrochemical catalysts.

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Bioinspired green deep eutectic solvents: preparation, catalytic activity, and biocompatibility

Cited by 24 publications

References 105 publications

Solubility and Stability of Carvedilol in Deep Eutectic Solvents: A Step Towards a Sustainable Pharmaceutical Formulation in the Liquid State

Solubility and Stability of Carvedilol in Deep Eutectic Solvents: A Step Towards a Sustainable Pharmaceutical Formulation in the Liquid State

From trash to cash: current strategies for bio-upcycling of recaptured monomeric building blocks from poly(ethylene terephthalate) (PET) waste

Utilization of Cobalt and its Oxide/Hydroxide Mediated by Ionic Liquids/Deep Eutectic Solvents as Catalysts in Water Splitting

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