Bioinspired Injectable Polyurethane Underwater Adhesive with Fast Bonding and Hemostatic Properties

Abstract

Underwater adhesives with injectable, organic solvent‐free, strong, fast adhesion, and hemostatic properties have become an urgent need in biomedical field. Herein, a novel polyurethane underwater adhesive (PUWA) inspired by mussels is developed utilizing the rapid post‐cure reaction of isocyanate esterification without organic solvents. The PUWA is created through the injectable two component curing process of component A (biocompatible polyurethane prepolymer) and component B (dopamine modified lysine derivatives: chain extender‐LDA and crosslinker‐L3DA). The two‐component adhesive cures quickly and firmly underwater, with an impressive bonding strength of 40 kPa on pork skin and excellent burst pressure of 394 mmHg. Moreover, the PUWA exhibits robust adhesion strength in hostile environments with acid, alkali and saline solutions. Combined with excellent biocompatibility and hemostatic performance, the PUWA demonstrates effectively sealing wounds and promoting healing. With the ability to bond diverse substrates rapidly and strongly, the PUWA holds significant potential for application in both biomedical and industrial fields.

Flexible Wound Patches Based on MXene/Quercetin-Waterborne Polyurethane Composites

“…Furthermore, both MXene/Que-WPU and Que-WPU exhibited excellent blood compatibility. The cytocompatibility of the film patches is essential for wound healing . It was evaluated via an in vitro MTT antitumor bioassay using HaCaT cells (Figure S5).…”

“…The cytocompatibility of the film patches is essential for wound healing. 39 It was evaluated via an in vitro MTT antitumor bioassay using HaCaT cells (Figure S5). The results revealed that HaCaT cell viability (%) was above 93.39% in a concentration range of 0.50 mg/mL.…”

A bioinspired injectable antioxidant hydrogel for prevention of postoperative adhesion

“…28–32 Among the various hydrogels, polyurethane-based hydrogels have exhibited exceptional performance. 32–36 Recently, hydrogels exhibited great potential for postoperative anti-adhesions. Particularly, physical isolation that involves the obstruction of contact between the surgical site and its surrounding tissue is convenient for injectable hydrogels.…”