Bioinspired Materials Chemistry I: Organic–Inorganic Nanocomposites

Fernandes, Francisco M.; Wicklein, Bernd; Ruiz‐Hitzky, Eduardo; Hill, Jonathan P.; Ariga, Katsuhiko

doi:10.1002/9781118310083.ch5

Cited by 3 publications

(2 citation statements)

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“…Recently, we reported the preparation of a new type of bionanohybrid materials based on lipid modified clay minerals. , Clay minerals are large surface materials and display various types of external and internal surfaces that are generally viable to modify . The bionanohybrids in this work are composed of the fibrous magnesium silicate sepiolite as solid support for the artificial lipid membrane (Figure ).…”

Section: Introductionmentioning

confidence: 99%

Phospholipid–Sepiolite Biomimetic Interfaces for the Immobilization of Enzymes

Wicklein

Darder

Ruiz-Hitzky

2011

ACS Appl. Mater. Interfaces

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Biomimetic interfaces based on phosphatidylcholine (PC) assembled to the natural silicate sepiolite were prepared for the stable immobilization of the urease and cholesterol oxidase enzymes. This is an important issue in practical advanced applications such as biocatalysis or biosensing. The supported lipid bilayer (BL-PC), prepared from PC adsorption, was used for immobilization of enzymes and the resulting biomimetic systems were compared to several other supported layers including a lipid monolayer (ML-PC), a mixed phosphatidylcholine/octyl-galactoside layer (PC-OGal), a cetyltrimethylammonium monolayer (CTA), and also to the bare sepiolite surface. Interfacial characteristics of these layers were investigated with a focus on layer packing density, hydrophilicity/hydrophobicity, and surface charge, which are being considered as key points for enzyme immobilization and stabilization of their biological activity. Cytoplasmic urease and membrane-bound cholesterol oxidase, which served as model enzymes, were immobilized on the different PC-based hybrid materials to probe their biomimetic character. Enzymatic activity was assessed by cyclic voltammetry and UV-vis spectrophotometry. The resulting enzyme/bio-organoclay hybrids were applied as active phase of a voltammetric urea biosensor and cholesterol bioreactor, respectively. Urease supported on sepiolite/BL-PC proved to maintain its enzymatic activity over several months while immobilized cholesterol oxidase demonstrated high reusability as biocatalyst. The results emphasize the good preservation of bioactivity due to the accommodation of the enzymatic system within the biomimetic lipid interface on sepiolite.

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Section: Introductionmentioning

confidence: 99%

Phospholipid–Sepiolite Biomimetic Interfaces for the Immobilization of Enzymes

Wicklein

Darder

Ruiz-Hitzky

2011

ACS Appl. Mater. Interfaces

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“…Therefore, those observed structures in biological systems have been recognized as practical tools and inspiration for fabrication of advanced materials. 19 Many important advances using biomimetic approaches involve carbonates and phosphates, for instance to prepare artificial nacre, bone, and other bionanocomposites [20][21][22][23][24][25][26][27] but silica, silicates and polysiloxanes also offer a viable alternative for preparation of biohybrids since their chemistry is extremely versatile, allowing the formation of hierarchical superstructures, supramolecular materials and other multifunctional bioinspired systems. 1,11,19,[27][28][29][30][31] The present contribution focuses on the diverse approaches to prepare biohybrid materials specifically based on clay minerals, by assembling of smectites and sepiolite to molecular and polymeric species of biological origin, with the aim of developing suitable nanostructured materials for potential biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

Advanced biohybrid materials based on nanoclays for biomedical applications

et al. 2012

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Bio-nanohybrids prepared by assembling natural polymers (polysaccharides, proteins, nucleic acids, etc) to nanosized silicates (nanoclays) and related solids (layered double hydroxides, LDHs) give rise to the so-called bionanocomposites constituting a group of biomaterials with potential applications in medicine. In this way, biopolymers, including chitosan, pectin, alginate, xanthan gum, ι-carrageenan, gelatin, zein, and DNA, as well as phospholipids such as phosphatidylcholine, have been incorporated in layered host matrices by means of ion-exchange mechanisms producing intercalation composites. Also bio-nanohybrids have been prepared by the assembly of diverse bio-polymers with sepiolite, a natural microfibrous magnesium silicate, in this case through interactions affecting the external surface of this silicate. The properties and applications of these resulting biomaterials as active phases of ion-sensors and biosensors, for potential uses as scaffolds for tissue engineering, drug delivery, and gene transfection systems, are introduced and discussed in this work. It is also considered the use of synthetic bionanocomposites as new substrates to immobilize microorganisms, as for instance to bind Influenza virus particles, allowing their application as effective low-cost vaccine adjuvants and carriers.

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Nano Approach

Chakravorty

Rather

Ali

et al. 2020

Advances in Medical Diagnosis, Treatment, and Care

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The mortality rate for infectious diseases in India, in 2017, was 416.75 per 100,000 persons, which is two times more than the United States of America due to multi-drug resistant pathogens and many more social and ethical challenges. Nano formulates are an alternative, eco-friendly solution. Nano medicine development from different food material is one of the fastest growing research fields. The nano formulated phytochemicals of spices can solve the delivery issues and even shows antimicrobial properties against multi-drug-resistant microorganisms as well as through Indian daily food. In this chapter, the recent research approaches in antimicrobial activity of nano formulation of different Indian spices and active phytochemicals of spices are comprehensively discussed. The most common methods for antimicrobial determination and the minimum inhibitory concentration of modified materials are also enlisted. The size of any nano material usually is 1 to 100 nanometers. Different nano formulates of different spices show antimicrobial activity against different pathogens.

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Bioinspired Materials Chemistry I: Organic–Inorganic Nanocomposites

Cited by 3 publications

References 103 publications

Phospholipid–Sepiolite Biomimetic Interfaces for the Immobilization of Enzymes

Phospholipid–Sepiolite Biomimetic Interfaces for the Immobilization of Enzymes

Advanced biohybrid materials based on nanoclays for biomedical applications

Nano Approach

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