Bioinspired polynorepinephrine nanoparticles as an efficient vehicle for enhanced drug delivery

Lu, Zhenzhen; Douek, Alon M.; Rozario, Ashley M.; Tabor, Rico F.; Kaslin, Jan; Follink, Bart; Teo, Boon Mian

doi:10.1039/c9tb02375e

Cited by 25 publications

(22 citation statements)

References 33 publications

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“…Notably, PDA structural properties can be tailored on specific application requirements by varying the synthetic conditions (i.e., DA concentration or buffer composition) [ 33 ]. Recently, norepinephrine (also known as noradrenaline), a neurotransmitter and vasopressor moiety, widely employed in medicine, has been proposed as a novel melanogenic precursor [ 34 , 35 ]. It undergoes oxidative polymerization forming both monodisperse nanoparticles [ 34 ] and thin coatings, with tough adhesive properties on different substrates.…”

Section: Synthetic Melanin-like Materials: Opportunities and Issuementioning

confidence: 99%

“…Recently, norepinephrine (also known as noradrenaline), a neurotransmitter and vasopressor moiety, widely employed in medicine, has been proposed as a novel melanogenic precursor [34,35]. It undergoes oxidative polymerization forming both monodisperse nanoparticles [34] and thin coatings, with tough adhesive properties on different substrates.…”

Section: Synthetic Melanin-like Materials: Opportunities and Issues Of Biomimetic Approachesmentioning

confidence: 99%

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Melanin and Melanin-Like Hybrid Materials in Regenerative Medicine

et al. 2020

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Melanins are a group of dark insoluble pigments found widespread in nature. In mammals, the brown-black eumelanins and the reddish-yellow pheomelanins are the main determinants of skin, hair, and eye pigmentation and play a significant role in photoprotection as well as in many biological functions ensuring homeostasis. Due to their broad-spectrum light absorption, radical scavenging, electric conductivity, and paramagnetic behavior, eumelanins are widely studied in the biomedical field. The continuing advancements in the development of biomimetic design strategies offer novel opportunities toward specifically engineered multifunctional biomaterials for regenerative medicine. Melanin and melanin-like coatings have been shown to increase cell attachment and proliferation on different substrates and to promote and ameliorate skin, bone, and nerve defect healing in several in vivo models. Herein, the state of the art and future perspectives of melanins as promising bioinspired platforms for natural regeneration processes are highlighted and discussed.

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Section: Synthetic Melanin-like Materials: Opportunities and Issuementioning

confidence: 99%

Section: Synthetic Melanin-like Materials: Opportunities and Issues Of Biomimetic Approachesmentioning

confidence: 99%

Melanin and Melanin-Like Hybrid Materials in Regenerative Medicine

et al. 2020

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“…Perhaps the most famous mussel-mimetic synthetic polymer material, and coating in particular, is poly(dopamine), PDA [44,65,[128][129][130][131][132][133][134][135], stemming from the oxidative polymerisation of dopamine in aqueous alkaline solutions. Virtually any substrate dip-coated in such a solution will receive a spontaneously formed adsorbate layer from the oxidation-driven self-polymerisation of dopamine, while self-assembled dopamine aggregates will form at the same time in solution.…”

Section: Chronology Of Synthetic Mussel Protein Analogues and Mimics: Structures And Synthesis/modification Strategiesmentioning

confidence: 99%

“…An array of studies (expanding in a very wide range of possible applications) summarised in several reviews [128][129][130][131] has followed the first polydopamine account [65], in which the process parameters were varied, aiming to address some of the issues with polydopamine coatings [128,129,131]: slow coating thickness build-up and high roughness (at least for some applications), narrow pH range, incorporation of Tris HCl in the polydopamine structure (due to its amine group) and at best modest mechanical properties. For this purpose, essentially all process parameters (concentration, solvent, temperature, immersion time, amine-free buffer molecules, additional oxidant, pH, additional UV/microwave energy) have been re-visited [128][129][130][131], including dopamine itself: it has been shown rather quickly that this oxidative self-polymerisation approach is applicable to a range of catecholamines, including l-DOPA itself [132] (this polymer however, poly(DOPA), is not to be confused with linear poly(l-DOPA) presented in Scheme 8), and norepinephrine [133]. Thermal annealing of PDA coatings (at 130 • C under vacuum) has been recently proposed as a facile way to enhance their mechanical robustness [134].…”

Section: Recent Advances In Mussel-inspired Polymers As Marine Antifouling Coatingsmentioning

confidence: 99%

Recent Advances in Mussel-Inspired Synthetic Polymers as Marine Antifouling Coatings

Manolakis

Azhar

2020

Coatings

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Synthetic oligomers and polymers inspired by the multifunctional tethering system (byssus) of the common mussel (genus Mytilus) have emerged since the 1980s as a very active research domain within the wider bioinspired and biomimetic materials arena. The unique combination of strong underwater adhesion, robust mechanical properties and self-healing capacity has been linked to a large extent to the presence of the unusual α-amino acid derivative l-DOPA (l-3,4-dihydroxyphenylalanine) as a building block of the mussel byssus proteins. This paper provides a short overview of marine biofouling, discussing the different marine biofouling species and natural defenses against these, as well as biomimicry as a concept investigated in the marine antifouling context. A detailed discussion of the literature on the Mytilus mussel family follows, covering elements of their biology, biochemistry and the specific measures adopted by these mussels to utilise their l-DOPA-rich protein sequences (and specifically the ortho-bisphenol (catechol) moiety) in their benefit. A comprehensive account is then given of the key catechol chemistries (covalent and non-covalent/intermolecular) relevant to adhesion, cohesion and self-healing, as well as of some of the most characteristic mussel protein synthetic mimics reported over the past 30 years and the related polymer functionalisation strategies with l-DOPA/catechol. Lastly, we review some of the most recent advances in such mussel-inspired synthetic oligomers and polymers, claimed as specifically aimed or intended for use in marine antifouling coatings and/or tested against marine biofouling species.

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“…Despite a widespread study of PDA, there is a paucity of research in the utilization of polynorepinephrine (PNE) as an innovative antifouling coating. Our group recently reported on the polymerization of PNE and demonstrated that PNE nanoparticles have excellent antifouling ability against both positively and negatively charged proteins (lysozyme and bovine serum albumin (BSA), respectively) …”

Section: Introductionmentioning

confidence: 99%

Polynorepinephrine as an Efficient Antifouling-Coating Material and Its Application as a Bacterial Killing Photothermal Agent

Quek

Meaney

et al. 2020

ACS Appl. Bio Mater.

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Biomedical device-related infection (BDI) is of great concern in modern clinical and medical applications. Various approaches to combat BDI are based on two major principles: the prevention of biofoulants adhering on medical devices and the ability to eradicate biofouling once formed. To minimize the risk of BDI, an antifouling coating with bactericidal ability is highly desirable. In this work, we report on the use of polynorepinephrine (PNE) as a promising strategy to prevent BDI due to its excellent antifouling and photothermal bacterial killing capabilities. PNE coatings show superior protein resistance against a model biofoulant (bovine serum albumin (BSA)) when compared with poly(ethylene glycol) (PEG) and polydopamine (PDA) coatings. The antifouling mechanism between BSA protein molecules and coating films is investigated using atomic force microscopy (AFM). We also demonstrate that PNE-modified surfaces show remarkable bacterial killing ability against both Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli bacteria after being irradiated with an 850 nm near-infrared (NIR) laser. These results indicate that PNE coatings present a highly promising candidate for biomedical antifouling applications.

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Bioinspired polynorepinephrine nanoparticles as an efficient vehicle for enhanced drug delivery

Abstract: Biocompatible polynorepinephrine based particles with excellent biocompatibility for efficient delivery of therapeutics to cancer cells.

Cited by 25 publications

References 33 publications

Melanin and Melanin-Like Hybrid Materials in Regenerative Medicine

Melanin and Melanin-Like Hybrid Materials in Regenerative Medicine

Recent Advances in Mussel-Inspired Synthetic Polymers as Marine Antifouling Coatings

Polynorepinephrine as an Efficient Antifouling-Coating Material and Its Application as a Bacterial Killing Photothermal Agent

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