Bioinspired Reactive Interfaces Based on Layered Double Hydroxides-Zn Rich Hydroxyapatite with Antibacterial Activity

Donnadio, Anna; Bini, Marzia; Centracchio, Catia; Mattarelli, Maurizio; Caponi, Silvia; Ambrogi, Valeria; Pietrella, Donatella; Michele, Alessandro Di; Vivani, Riccardo; Nocchetti, Morena

doi:10.1021/acsbiomaterials.0c01643

Cited by 22 publications

(15 citation statements)

References 60 publications

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“…The region between layers can store a large amount of bioactive ions where drugs are released in a sustained manner. In addition, LDHs can also be combined with other materials such as hydroxyapatite without affecting their own structure (Donnadio et al, 2021), which is beneficial for realizing the multi-functionalization of galliumcontaining materials. Li K. et al (2021) and Donnadio et al (2021) constructed and characterized gallium (Ga)-strontium (Sr) layered double hydroxides (Figure 5A) and gallium (Ga)-zinc (Zn) layered double hydroxides, respectively, both of which exhibited sustained release of Ga ions.…”

Section: Design Of Gallium-containing Layered Double Hydroxidementioning

confidence: 99%

“…In addition, LDHs can also be combined with other materials such as hydroxyapatite without affecting their own structure (Donnadio et al, 2021), which is beneficial for realizing the multi-functionalization of galliumcontaining materials. Li K. et al (2021) and Donnadio et al (2021) constructed and characterized gallium (Ga)-strontium (Sr) layered double hydroxides (Figure 5A) and gallium (Ga)-zinc (Zn) layered double hydroxides, respectively, both of which exhibited sustained release of Ga ions. On day 21, the concentrations of Ga (III) released from LDH 250 and LDH reached almost 1.75 and 1.25 μg/ml, respectively (Figure 5B).…”

Section: Design Of Gallium-containing Layered Double Hydroxidementioning

confidence: 99%

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Advancement of Gallium and Gallium-Based Compounds as Antimicrobial Agents

Huang

et al. 2022

Front. Bioeng. Biotechnol.

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With the abuse and misuse of antibiotics, antimicrobial resistance has become a challenging issue in the medical system. Iatrogenic and non-iatrogenic infections caused by multidrug-resistant (MDR) pathogens pose serious threats to global human life and health because the efficacy of traditional antibiotics has been greatly reduced and the resulting socio-economic burden has increased. It is important to find and develop non-antibiotic-dependent antibacterial strategies because the development of new antibiotics can hardly keep pace with the emergence of resistant bacteria. Gallium (III) is a multi-target antibacterial agent that has an excellent antibacterial activity, especially against MDR pathogens; thus, a gallium (III)-based treatment is expected to become a new antibacterial strategy. However, some limitations of gallium ions as antimicrobials still exist, including low bioavailability and explosive release. In recent years, with the development of nanomaterials and clathrates, the progress of manufacturing technology, and the emergence of synergistic antibacterial strategies, the antibacterial activities of gallium have greatly improved, and the scope of application in medical systems has expanded. This review summarizes the advancement of current optimization for these key factors. This review will enrich the knowledge about the efficiency and mechanism of various gallium-based antibacterial agents and provide strategies for the improvement of the antibacterial activity of gallium-based compounds.

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Section: Design Of Gallium-containing Layered Double Hydroxidementioning

confidence: 99%

Section: Design Of Gallium-containing Layered Double Hydroxidementioning

confidence: 99%

Advancement of Gallium and Gallium-Based Compounds as Antimicrobial Agents

Huang

et al. 2022

Front. Bioeng. Biotechnol.

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“…An impairment in just one single component at the nano-, sub-micro- or microscale can affect the biomechanics of the entire bone material [6,7]. For this reason, considering the lamellar organization at each length scale is fundamental both for understanding its complex mechanical properties and for modelling prostheses and bioinspired materials [8,9]. In addition, knowledge of bone tissue physiology can be crucial to detecting micro-alterations in the structure that can be early manifestations of orthopaedic diseases [10].…”

Section: Introductionmentioning

confidence: 99%

Brillouin–Raman microspectroscopy for the morpho-mechanical imaging of human lamellar bone

Cardinali

Michele

Mattarelli

et al. 2022

J. R. Soc. Interface.

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Bone has a sophisticated architecture characterized by a hierarchical organization, starting at the sub-micrometre level. Thus, the analysis of the mechanical and structural properties of bone at this scale is essential to understand the relationship between its physiology, physical properties and chemical composition. Here, we unveil the potential of Brillouin–Raman microspectroscopy (BRaMS), an emerging correlative optical approach that can simultaneously assess bone mechanics and chemistry with micrometric resolution. Correlative hyperspectral imaging, performed on a human diaphyseal ring, reveals a complex microarchitecture that is reflected in extremely rich and informative spectra. An innovative method for mechanical properties analysis is proposed, mapping the intermixing of soft and hard tissue areas and revealing the coexistence of regions involved in remodelling processes, nutrient transportation and structural support. The mineralized regions appear elastically inhomogeneous, resembling the pattern of the osteons' lamellae, while Raman and energy-dispersive X-ray images through scanning electron microscopy show an overall uniform distribution of the mineral content, suggesting that other structural factors are responsible for lamellar micromechanical heterogeneity. These results, besides giving an important insight into cortical bone tissue properties, highlight the potential of BRaMS to access the origin of anisotropic mechanical properties, which are almost ubiquitous in other biological tissues.

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“…LDH with antimicrobial properties can be prepared by selecting a proper composition of the layers and of the interlayer and by exploiting the surface properties. The right choice of intralayer metals with antimicrobial activity such as Cu, Zn, or Ga [ 29 , 30 ], or the intercalation of antibiotics, allowed LDH with good antibacterial properties to be obtained [ 31 , 32 ]. Immobilization of metal NPs, such as AgNPs, was achieved thanks to the presence of layer surface OH groups, acting as stabilizing agents.…”

Section: Introductionmentioning

confidence: 99%

Overcoming Antibiotic Resistance: Playing the ‘Silver Nanobullet’ Card

et al. 2022

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Enhancing the antibacterial activity of old antibiotics by a multitarget approach, such as combining antibiotics with metal nanoparticles, is a valuable strategy to overcome antibacterial resistance. In this work, the synergistic antimicrobial effect of silver nanoparticles and antibiotics, immobilized on a solid support, was investigated. Nanometric layered double hydroxides (LDH) based on Zn(II) and Al(III) were prepared by the double microemulsion technique. The dual function of LDH as an anionic exchanger and support for metal nanoparticles was exploited to immobilize both silver and antibiotics. Cefazolin (CFZ), a β-lactam, and nalidixic acid (NAL), a quinolone, were selected and intercalated into LDH obtaining ZnAl-CFZ and ZnAl-NAL samples. These samples were used for the growth of silver nanoparticles with dimension ranging from 2.5 to 8 nm. Silver and antibiotics release profiles, from LDH loaded with antibiotics and Ag/antibiotics, were evaluated in two different media: water and phosphate buffer. Interestingly, the release profiles are affected by both the acceptor media and the presence of silver. The synergistic antibacterial activity of LDH containing both silver and antibiotics were investigated on gram-positives (Staphylococcus aureus and Streptococcus pneumoniae) and gram-negatives (Pseudomonas aeruginosa) and compared with the plain antimicrobials and LDH containing only antibiotics or silver.

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Bioinspired Reactive Interfaces Based on Layered Double Hydroxides-Zn Rich Hydroxyapatite with Antibacterial Activity

Cited by 22 publications

References 60 publications

Advancement of Gallium and Gallium-Based Compounds as Antimicrobial Agents

Advancement of Gallium and Gallium-Based Compounds as Antimicrobial Agents

Brillouin–Raman microspectroscopy for the morpho-mechanical imaging of human lamellar bone

Overcoming Antibiotic Resistance: Playing the ‘Silver Nanobullet’ Card

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