Bioinspired Spiky Peroxidase‐Mimics for Localized Bacterial Capture and Synergistic Catalytic Sterilization

Yang, Yuliang; Wu, Xizheng; Ma, Lang; He, Chao; Cao, Sujiao; Long, Yanping; Huang, Jianbo; Rodriguez, Raúl D.; Cheng, Chong; Zhao, Changsheng; Qiu, Li

doi:10.1002/adma.202005477

Cited by 113 publications

(105 citation statements)

References 59 publications

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“…[25,26] Recently, many types of ROS catalytic nanoagents have been found to show efficient catalytic activity for the CDT process, like noble metal Pd nanomaterials, metal oxides, and metalorganic frameworks. [20,[27][28][29][30][31][32] At present, the semiconductor materials (e.g., TiO 2 ) and conjugated organic structure (e.g., porphyrin) are the main materials that can be utilized to integrate CDT, SDT, and PDT in one nanoplatform. However, the CDT efficiency of TiO 2 -based semiconductor materials is relatively low.…”

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confidence: 99%

Pd‐Single‐Atom Coordinated Biocatalysts for Chem‐/Sono‐/Photo‐Trimodal Tumor Therapies

et al. 2021

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clinical cancer treatments. [1] Though some conventional methods, such as surgery, radiotherapy, and chemotherapy, have been used to treat malignant melanoma in clinics, these methods have exhibited limited treatment efficiencies in inhibiting tumor growth, leading to low patient survival rates. Therefore, more creative and efficient ways are urgently needed to overcome these clinical bottlenecks; for instance, gene therapy, photodynamic therapy (PDT), photothermal therapy, sonodynamic therapy (SDT), and immunotherapy. [2][3][4][5][6] However, due to the diversity, complexity, and heterogeneity of the MM tumor, [7] mono-modal therapy has been found to show limited treatment efficiency for MM tumors. Consequently, searching for integrated therapeutic strategies with multi-modal therapeutics is highly necessary to achieve remarkable antitumor effects. [8][9][10][11][12] The SDT and PDT have been selected as potential clinical methods for treating a wide range of superficial and localized tumors. They utilize the sono-irradiation or photoexcitation to generate highly reactive oxygen species (ROS), such as singlet oxygen ( 1 O 2 ) and hydroxyl radicals (•OH). [13][14][15][16][17] Owing to the temporal and spatial management over the localization of the sound or light, the ROS can be generated precisely in the tumor tissues instead of normal tissue, thus minimizing the side effects. [18][19][20] The unique quantity of deep tissue penetration and little side The diversity, complexity, and heterogeneity of malignant tumor seriously undermine the efficiency of mono-modal treatment. Recently, multi-modal therapeutics with enhanced antitumor efficiencies have attracted increasing attention. However, designing a nanotherapeutic platform with uniform morphology in nanoscale that integrates with efficient chem-/sono-/phototrimodal tumor therapies is still a great challenge. Here, new and facile Pd-single-atom coordinated porphyrin-based polymeric networks as biocatalysts, namely, Pd-Pta/Por, for chem-/sono-/photo-trimodal tumor therapies are designed. The atomic morphology and chemical structure analysis prove that the biocatalyst consists of atomic Pd-N coordination networks with a Pd-N 2 -Cl 2 catalytic center. The characterization of peroxidase-like catalytic activities displays that the Pd-Pta/Por can generate abundant •OH radicals for chemodynamic therapies. The ultrasound irradiation or laser excitation can significantly boost the catalytic production of 1 O 2 by the porphyrin-based sono-/photosensitizers to achieve combined sono-/photodynamic therapies. The superior catalytic production of •OH is further verified by density functional theory calculation. Finally, the corresponding in vitro and in vivo experiments have demonstrated their synergistic chem-/sono-/photo-trimodal antitumor efficacies. It is believed that this study provides new promising single-atom-coordinated polymeric networks with highly efficient biocatalytic sites and synergistic trimodal therapeutic effects, which may inspire many new findings in rea...

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confidence: 99%

Pd‐Single‐Atom Coordinated Biocatalysts for Chem‐/Sono‐/Photo‐Trimodal Tumor Therapies

et al. 2021

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“…Our group recently found two other different reaction mechanisms for the H 2 O 2 assisted generation of •OH radicals. [55,56] In one report, as shown in Figure 2B, we found that the Pd-single-atom coordinated biocatalysts with a Pd-N catalytic center could generate two •OH radicals by DFT calculation. The H 2 O 2 adsorbs onto the Pd atom's active site first, then *H 2 O 2 will spontaneously remove an •OH.…”

Section: Catalytic Mechanismsmentioning

confidence: 79%

ROS‐Catalytic Transition‐Metal‐Based Enzymatic Nanoagents for Tumor and Bacterial Eradication

Cao

Xiang

et al. 2021

Adv Funct Materials

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The extensive research into developing new nanomedicines during the past few years has witnessed significant progress in diverse biomedical fields, especially for combating drug resistance in antitumor and antibacterial therapies. Recently, transition-metal-based enzymatic nanoagents (TM-EnzNAs) with catalytic production of reactive oxygen species (ROS) have been designed and intensively explored, which have become powerful nanoplatforms and exciting research frontiers in constructing next-generation nanotherapeutics to combat drug-resistant tumors and bacteria. Here, the focus is on the recent design, fundamental principles, and material chemistries in developing and applications of TM-EnzNAs. At first, the different ROS-producing mechanisms and the key factors to enhance ROS level are carefully concluded, and the analytic methods are systematically summarized. Then, the rationally engineered TM-EnzNAs via different synthetic approaches with high ROS producing efficiencies are comprehensively discussed, especially the catalytic activities, mechanisms, and structure-function relationships. After that, the representative applications of these ROS-catalytic TM-EnzNAs for antitumor and bacterial eradication are summarized in detail. Finally, the primary challenges and future perspectives have also been outlined. It is anticipated new therapeutic insights into combating drug-resistant tumors and bacteria will be provided, and significant new inspiration for designing future enzymatic nanoagents is offered.

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“…[ 12 ] Different types of noble metal NPs, such as Au, Ag, platinum group metals (Pd, Pt, Ru, Rh, Os, Ir), and their alloy NPs, have been widely used in different fields, including sensing, biomedicine, and catalysis. [ 104–112 ]…”

Section: Engineering Biocatalytic and Antioxidant Nanostructures: Rational Design And Catalytic Activitiesmentioning

confidence: 99%

Biocatalytic and Antioxidant Nanostructures for ROS Scavenging and Biotherapeutics

Wang

Zhu

Deng

et al. 2021

Adv Funct Materials

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In human systems, reactive oxygen species (ROS) significantly affect different physiological activities and play critical roles in diverse living processes. It is widely known that excessive ROS generation in inflammatory tissues can further deteriorate the localized tissue injury and cause chronic diseases. Though promising for reducing ROS levels, many antioxidant molecules and natural enzymes suffer from abundant intrinsic limitations. Recently, a series of biocatalytic or antioxidant nanostructures have been designed with distinctive ROS scavenging capabilities, which show promising activities to overcome these kernel challenges. In this timely review, the most recent advances in engineering biocatalytic and antioxidant nanostructures for ROS scavenging are summarized. First, the ROS scavenging principles and corresponding methods for testing various enzymatic activities are carefully concluded. Subsequently, the rationally designed nanostructures with high ROS scavenging efficiencies are comprehensively discussed, especially on the catalytic activities, mechanisms, and structure‐function relationships. After that, the representative applications of these ROS scavenging nanostructures for diverse biotherapeutics are summarized in detail. At last, the primary challenges and future perspectives in this emerging research frontier have also been outlined. It is believed that this progress review will offer a cutting‐edge understanding and guidance to engineering future high‐performance ROS scavenging nanostructures for broad biotherapeutic applications.

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Bioinspired Spiky Peroxidase‐Mimics for Localized Bacterial Capture and Synergistic Catalytic Sterilization

Cited by 113 publications

References 59 publications

Pd‐Single‐Atom Coordinated Biocatalysts for Chem‐/Sono‐/Photo‐Trimodal Tumor Therapies

Pd‐Single‐Atom Coordinated Biocatalysts for Chem‐/Sono‐/Photo‐Trimodal Tumor Therapies

ROS‐Catalytic Transition‐Metal‐Based Enzymatic Nanoagents for Tumor and Bacterial Eradication

Biocatalytic and Antioxidant Nanostructures for ROS Scavenging and Biotherapeutics

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