Bioinspired Surface Ligand Engineering Regulates Electron Transfers in Gold Clusterzymes to Enhance the Catalytic Activity for Improving Sensing Performance

Fan, Jinsong; Zhang, Xiyue; Tan, Wenlong; Feng, Zhenzhen; Li, Kun

doi:10.1021/acs.nanolett.4c02175

Nano Lett.

2024

DOI: 10.1021/acs.nanolett.4c02175

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Bioinspired Surface Ligand Engineering Regulates Electron Transfers in Gold Clusterzymes to Enhance the Catalytic Activity for Improving Sensing Performance

Jinsong Fan,

Xiyue Zhang,

Wenlong Tan

et al.

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Cited by 5 publications

References 59 publications

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A Novel “Three‐in‐One” Copper‐Based Metal‐Organic Framework Nanozyme Eradicates Colorectal Cancer and Overcomes Chemoresistance for Tumor Therapy

Dong,

Cao,

Yuan

et al. 2024

Advanced Science

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Despite considerable advancements in the treatment of colorectal cancer (CRC), the overall survival rate for patients with advanced CRC remains below 50%, primarily due to challenges posed by drug resistance and metastasis. Here, a novel “Three‐in‐One” Cu‐based metal‐organic framework nanozyme with peroxidase‐like (POD‐like) activity has been successfully developed, aiming to promote CRC cell death by dual targeting of oxidative stress and copper ion homeostasis, which could promote CRC cell death via apoptosis and cuproptosis, and facilitate hypoxia‐inducible factor 1α (HIF‐1α) degradation, leading to the reversal of chemoresistance in tumor therapy. These nanozymes, composed of copper and 2‐propylimidazole (Cu‐PrIm), feature a distorted Cu‐N4 catalytic active center that mimics natural enzyme structures consisting of copper and histidine residues, endowing them with enzyme‐like activities. The antitumor efficacy of Cu‐PrIm nanozymes is validated in various in vivo models of CRC. Especially Cu‐PrIm nanozymes exhibit excellent biocompatibility, biodegradability, and a tolerable toxicity profile in mouse models, making them a strong candidate for clinical translation. Taken together, the study introduces a novel therapeutic paradigm in CRC treatment by targeting these vulnerabilities and leveraging the potential using “Three‐in‐One” Cu‐PrIm nanozymes to address multiple pathways simultaneously.

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A Novel “Three‐in‐One” Copper‐Based Metal‐Organic Framework Nanozyme Eradicates Colorectal Cancer and Overcomes Chemoresistance for Tumor Therapy

Dong,

Cao,

Yuan

et al. 2024

Advanced Science

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Specific and enzyme-free monitoring of propiconazole pesticide residues in vegetables with a portable nanozyme-based paper sensor

Xu,

Sun,

Zhou

et al. 2025

Food Chemistry

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Utilizing DNA Logic Device for Precise Detection of Circulating Tumor Cells via High Catalytic Activity Au Nanoparticle Anchoring

Guo,

Sun,

Tao

et al. 2024

Anal. Chem.

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As medical advancements turn most cancers into manageable chronic diseases, new challenges arise in cancer recurrence monitoring. Detecting circulating tumor cells (CTCs) is crucial for monitoring cancer recurrence, but the current methods are cumbersome and costly. This study developed a new CTC detection system combining DNA aptamer recognition, hybridization chain reaction (HCR) technology, and DNA logic devices, enabling the onestep recognition of CTCs by identifying multiple membrane proteins. After catalytically active Au nanoparticles were attached through reduction synthesis in situ onto the DNA hybridization strands of the CTCs surface, a 3,3′,5,5′-tetramethylbenzidine (TMB) colorimetric reaction was used to detect CTCs concentration via peroxidase-like catalysis. With this CTCs detection reporting system, we achieved an LOD of 4 cells/mL using an ultraviolet−visible (UV−vis) spectrophotometer. At certain concentrations, CTCs could even be detected visually without the need for an instrument. The development of this CTCs detection reporting system provided a convenient, reliable, and cost-effective detection strategy for widespread CTCs-based cancer recurrence monitoring.

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Bioinspired Surface Ligand Engineering Regulates Electron Transfers in Gold Clusterzymes to Enhance the Catalytic Activity for Improving Sensing Performance

Cited by 5 publications

References 59 publications

A Novel “Three‐in‐One” Copper‐Based Metal‐Organic Framework Nanozyme Eradicates Colorectal Cancer and Overcomes Chemoresistance for Tumor Therapy

A Novel “Three‐in‐One” Copper‐Based Metal‐Organic Framework Nanozyme Eradicates Colorectal Cancer and Overcomes Chemoresistance for Tumor Therapy

Specific and enzyme-free monitoring of propiconazole pesticide residues in vegetables with a portable nanozyme-based paper sensor

Utilizing DNA Logic Device for Precise Detection of Circulating Tumor Cells via High Catalytic Activity Au Nanoparticle Anchoring

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