Bioinspired Synthesis and Characterization of Gadolinium-Labeled Magnetite Nanoparticles for Dual ContrastT1- andT2-Weighted Magnetic Resonance Imaging

Bae, Ki Hyun; Kim, Young Beom; Lee, Yuhan; Hwang, Jinyoung; Park, Hyunwook; Park, Tae Gwan

doi:10.1021/bc900424u

Cited by 188 publications

(149 citation statements)

References 37 publications

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“…Another approach has been the addition of a Gd chelate to the polymer coating of SPIONs. 82,83 This dual contrast agent efficiently reduces both T 1 and T 2 relaxation times and achieved a good contrast in mice for both T 1 -and T 2 -weighted images. This unique combination allows for the acquisition of both highly detailed T 1 -and T 2 -weighted images with a single imaging nanoprobe.…”

Section: Dual (T 1 and T 2 ) Contrast Agentsmentioning

confidence: 96%

Nanoparticles in magnetic resonance imaging: from simple to dual contrast agents

Estelrich¹,

Sánchez-Martín²,

Busquets³

2015

IJN

281

106

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Magnetic resonance imaging (MRI) has become one of the most widely used and powerful tools for noninvasive clinical diagnosis owing to its high degree of soft tissue contrast, spatial resolution, and depth of penetration. MRI signal intensity is related to the relaxation times ( T 1 , spin–lattice relaxation and T 2 , spin–spin relaxation) of in vivo water protons. To increase contrast, various inorganic nanoparticles and complexes (the so-called contrast agents) are administered prior to the scanning. Shortening T 1 and T 2 increases the corresponding relaxation rates, 1/ T 1 and 1/ T 2 , producing hyperintense and hypointense signals respectively in shorter times. Moreover, the signal-to-noise ratio can be improved with the acquisition of a large number of measurements. The contrast agents used are generally based on either iron oxide nanoparticles or ferrites, providing negative contrast in T 2 -weighted images; or complexes of lanthanide metals (mostly containing gadolinium ions), providing positive contrast in T 1 -weighted images. Recently, lanthanide complexes have been immobilized in nanostructured materials in order to develop a new class of contrast agents with functions including blood-pool and organ (or tumor) targeting. Meanwhile, to overcome the limitations of individual imaging modalities, multimodal imaging techniques have been developed. An important challenge is to design all-in-one contrast agents that can be detected by multimodal techniques. Magnetoliposomes are efficient multimodal contrast agents. They can simultaneously bear both kinds of contrast and can, furthermore, incorporate targeting ligands and chains of polyethylene glycol to enhance the accumulation of nanoparticles at the site of interest and the bioavailability, respectively. Here, we review the most important characteristics of the nanoparticles or complexes used as MRI contrast agents.

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Section: Dual (T 1 and T 2 ) Contrast Agentsmentioning

confidence: 96%

Nanoparticles in magnetic resonance imaging: from simple to dual contrast agents

Estelrich¹,

Sánchez-Martín²,

Busquets³

2015

IJN

281

106

View full text Add to dashboard Cite

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“…Considering the different penetration depths and spatial/time resolutions of multiple imaging devices, a new strategy towards the development of NP-based dual mode contrast agent (DMCA), where two different modes of imaging (T 1 -and T 2 -weight MR imaging) are utilized simultaneously, is necessary and amenable for significant improvement of the diagnosis accuracy. For instance, Park and coworkers reported an approach to fabricating gadolinium-labeled magnetite NPs as dual-contrast agents for T 1 -and T 2 -weighted MR imaging [24]. Cheon and coworkers demonstrated a "magnetically decoupled" core-shell design concept to develop DMCA [25].…”

Section: Introductionmentioning

confidence: 99%

Targeted dual-contrast T1- and T2-weighted magnetic resonance imaging of tumors using multifunctional gadolinium-labeled superparamagnetic iron oxide nanoparticles

et al. 2011

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“…A particular advantage of the ''grafting to'' approach is that the density of one or multiple surface-presented (bio)ligands can be tailored by co-adsorbing differently functionalized dispersants in one or several subsequent assembly steps. 22,63 The polymer grafting density achieved using the ''grafting to'' approach has on flat surfaces been shown to be significantly lower than for the ''grafting from'' approach. 62 This difference in polymer grafting density is a result of the steric repulsion of adjacent polymer chains that defines the density achievable for the grafting to approach, but not limiting polymers grown in situ on the surface using grafting from strategies.…”

mentioning

confidence: 99%

Stabilization and functionalization of iron oxide nanoparticles for biomedical applications

2011

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Superparamagnetic iron oxide nanoparticles (NPs) are used in a rapidly expanding number of research and practical applications in the biomedical field, including magnetic cell labeling separation and tracking, for therapeutic purposes in hyperthermia and drug delivery, and for diagnostic purposes, e.g., as contrast agents for magnetic resonance imaging. These applications require good NP stability at physiological conditions, close control over NP size and controlled surface presentation of functionalities. This review is focused on different aspects of the stability of superparamagnetic iron oxide NPs, from its practical definition to its implementation by molecular design of the dispersant shell around the iron oxide core and further on to its influence on the magnetic properties of the superparamagnetic iron oxide NPs. Special attention is given to the selection of molecular anchors for the dispersant shell, because of their importance to ensure colloidal and functional stability of sterically stabilized superparamagnetic iron oxide NPs. We further detail how dispersants have been optimized to gain close control over iron oxide NP stability, size and functionalities by independently considering the influences of anchors and the attached sterically repulsive polymer brushes. A critical evaluation of different strategies to stabilize and functionalize core-shell superparamagnetic iron oxide NPs as well as a brief introduction to characterization methods to compare those strategies is given.

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Bioinspired Synthesis and Characterization of Gadolinium-Labeled Magnetite Nanoparticles for Dual ContrastT₁- andT₂-Weighted Magnetic Resonance Imaging

Cited by 188 publications

References 37 publications

Nanoparticles in magnetic resonance imaging: from simple to dual contrast agents

Nanoparticles in magnetic resonance imaging: from simple to dual contrast agents

Targeted dual-contrast T1- and T2-weighted magnetic resonance imaging of tumors using multifunctional gadolinium-labeled superparamagnetic iron oxide nanoparticles

Stabilization and functionalization of iron oxide nanoparticles for biomedical applications

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