Bioinspired zwitterionic dopamine-functionalized liquid-metal nanodroplets for antifouling application

He, Baoluo; Wang, Peng; Wang, Biwen; Du, Yixuan; Ji, Le; Liu, Shujuan; Ye, Qian; Zhou, Feng

doi:10.1016/j.porgcoat.2022.106922

Cited by 11 publications

(7 citation statements)

References 38 publications

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“…These results indicate that the formation of a protein corona should be taken into consideration in future research involving biological applications of Ga droplets. One possible solution to control the fouling process of Ga droplets is to attach molecules on the surface such as positive surfactants or polymers, such as poly(ethylene glycol) (PEG) or zwitterionic polymers …”

Section: Resultsmentioning

confidence: 99%

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Assessment of the Cytotoxicity of Nano Gallium Liquid Metal Droplets for Biomedical Applications

Cheeseman

Bryant

Huang

et al. 2022

ACS Appl. Nano Mater.

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Gallium-based liquid metals (LMs) have emerged as novel materials for biomedical applications. Gallium (Ga) is considered significantly less toxic than other LMs, such as mercury. However, Ga droplets have not been thoroughly assessed for their cytotoxicity. Here, we report the concentration-dependent cytotoxic effects of Ga nano- and microdroplets on HaCaT cells, a human keratinocyte cell line. We found that Ga droplets demonstrated substantial cytotoxic effects at 1000 μg/mL after 24 h exposure, while lower concentrations such as 500 μg/mL indicated only a slight reduction in cell viability at longer exposure times. At higher concentrations, it was observed that the cells were unable to form confluent layers and the cytoplasmic membrane became damaged. The formation of a protein corona on the Ga droplets in cell media is also described, which will be an important consideration for future research on Ga droplets for bio-applications. Importantly, this work provides an indication of the concentration at which Ga droplets become damaging to human cells, which will be useful information for a wide range of researchers and regulatory bodies.

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Section: Resultsmentioning

confidence: 99%

“…One possible solution to control the fouling process of Ga droplets is to attach molecules on the surface such as positive surfactants 38 or polymers, 45 such as poly(ethylene glycol) (PEG) 46 or zwitterionic polymers. 47 2.2. Evaluation of the Cytotoxic Effects of Ga Droplets.…”

Section: Synthesis and Characterization Of Ga Dropletsmentioning

confidence: 99%

Assessment of the Cytotoxicity of Nano Gallium Liquid Metal Droplets for Biomedical Applications

Cheeseman

Bryant

Huang

et al. 2022

ACS Appl. Nano Mater.

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“…However, these encapsulated LMNPs suffer from complicated fabrication processes and chemistry, broad size distribution, potential environmental threats from the utilization of non-degradable materials, and a lack of sufficient functional groups to interact with the hydrogel matrix. 19,29,30 Polydopamine (PDA), inspired by natural melanin and mussel adhesive proteins, has intrinsic versatile surface adhesion properties and abundant functional groups. 31 On one hand, its catechol groups can coordinate with Ga 3+ in LMNPs to form a stable shell, preventing LMNPs from fracture and exudation to the hydrogel network.…”

Section: Materials Horizonsmentioning

confidence: 99%

Ultra-robust, high-adhesive, self-healing, and photothermal zwitterionic hydrogels for multi-sensory applications and solar-driven evaporation

et al. 2023

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“…121 Building on this knowledge, other studies have suggested that the Ga 3+ ion enacts its bactericidal effect by interfering with several redox-related metabolic processes. 128 Films of GaLM can also be the source of species that kill bacteria. One study involved the deposition of a thin film of EGaIn onto a polyvinyl chloride substrate.…”

Section: Introductionmentioning

confidence: 99%

“…For example, Ga(III)-protoporphyrin IX, Ga(NO 3 ) 3 , and Ga(III)-maltolate have been shown to provide bactericidal activity against the majority of multidrug-resistant ESKAPE pathogens via disruption of iron-dependent metabolic pathways . Building on this knowledge, other studies have suggested that the Ga 3+ ion enacts its bactericidal effect by interfering with several redox-related metabolic processes …”

Section: Introductionmentioning

confidence: 99%

Gallium Liquid Metal: Nanotoolbox for Antimicrobial Applications

et al. 2023

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The proliferation of drug resistance in microbial pathogens poses a significant threat to human health. Hence, treatment measures are essential to surmount this growing problem. In this context, liquid metal nanoparticles are promising. Gallium, a post-transition metal notable for being a liquid at physiological temperature, has drawn attention for its distinctive properties, high antimicrobial efficacy, and low toxicity. Moreover, gallium nanoparticles demonstrate anti-inflammatory properties in immune cells. Gallium can alloy with other metals and be prepared in various composites to modify and tailor its characteristics and functionality. More importantly, the bactericidal mechanism of gallium liquid metal could sidestep the threat of emerging drug resistance mechanisms. Building on this rationale, gallium-based liquid metal nanoparticles can enable impactful and innovative strategic pathways in the battle against antimicrobial resistance. This review outlines the characteristics of gallium-based liquid metals at the nanoscale and their corresponding antimicrobial mechanisms to provide a comprehensive yet succinct overview of their current antimicrobial applications. In addition, challenges and opportunities that require further research efforts have been identified and discussed.

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Bioinspired zwitterionic dopamine-functionalized liquid-metal nanodroplets for antifouling application

Cited by 11 publications

References 38 publications

Assessment of the Cytotoxicity of Nano Gallium Liquid Metal Droplets for Biomedical Applications

Assessment of the Cytotoxicity of Nano Gallium Liquid Metal Droplets for Biomedical Applications

Ultra-robust, high-adhesive, self-healing, and photothermal zwitterionic hydrogels for multi-sensory applications and solar-driven evaporation

Gallium Liquid Metal: Nanotoolbox for Antimicrobial Applications

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