Bioisosteric heterocyclic analogues of natural bioactive flavonoids by scaffold-hopping approaches: State-of-the-art and perspectives in medicinal chemistry

La Monica, Gabriele; Bono, Alessia; Alamia, Federica; Lauria, Antonino; Martorana, Annamaria

doi:10.1016/j.bmc.2024.117791

Bioorganic & Medicinal Chemistry

2024

DOI: 10.1016/j.bmc.2024.117791

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Bioisosteric heterocyclic analogues of natural bioactive flavonoids by scaffold-hopping approaches: State-of-the-art and perspectives in medicinal chemistry

Gabriele La Monica,

Alessia Bono,

Federica Alamia

et al.

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Cited by 4 publications

References 145 publications

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2024

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Targeting cancer using scaffold-hopping approaches: illuminating SAR to improve drug design

Shivani,

Abdul Rahaman,

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Synthesis of azaflavanones and alpha-ylidene azaflavanones

Pinheiro,

Oliveira,

Greco

et al. 2024

Tetrahedron

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Synthesis of Thiaphenanthridinones from Sulfinate Esters and 2-Borylanilines

Nakamura,

Suzuki,

Yoshida

2024

Org. Lett.

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A facile palladium-catalyzed synthesis of thiaphenanthridinones from sulfinate esters and 2-borylanilines is disclosed. Various sulfur analogs of phenanthridinones were synthesized by bromide-selective cross-coupling and cyclization in one step. Further transformations of the obtained thiaphenanthridinones allowed preparing a broad range of thiaphenanthridinone derivatives involving analogs of bioactive compounds.

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Bioisosteric heterocyclic analogues of natural bioactive flavonoids by scaffold-hopping approaches: State-of-the-art and perspectives in medicinal chemistry

Cited by 4 publications

References 145 publications

Targeting cancer using scaffold-hopping approaches: illuminating SAR to improve drug design

Targeting cancer using scaffold-hopping approaches: illuminating SAR to improve drug design

Synthesis of azaflavanones and alpha-ylidene azaflavanones

Synthesis of Thiaphenanthridinones from Sulfinate Esters and 2-Borylanilines

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