Biologia futura: medicinal plants-derived bioactive peptides in functional perspective—a review

Meena, Supriya; Kanthaliya, Bhanupriya; Joshi, Abhishek; Khan, Farhana Islam; Arora, Jaya

doi:10.1007/s42977-020-00042-4

Cited by 12 publications

(4 citation statements)

References 96 publications

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“…This concentration is higher than reported for hydrolysates of Moringa oleifera seed flour with pepsin and trypsin, 2.5 h (0.883 mg mL -1 ; González Garza et al, 2017) and Amaranthus hypochondriacus seeds with alcalase, 5 h (0.6 mg mL -1 ; Quiroga et al, 2017). However, the IC 50 of the hydrolyzed moringa seeds was lower than that of Perilla frutescens seeds with flavourzyme, 4 h (5.124 mg mL -1 ; Meena et al, 2020;Park and Yoon, 2019).…”

Section: Assays Of Angiotensin-converting Enzymementioning

confidence: 74%

Characterization of seed storage protein of Moringa oleifera and analyses of their bioactive peptide’s nutraceutical properties

Peraza-Juan¹,

Espinoza-Sánchez²,

Lara-Reyes³

et al. 2022

Acta Sci Pol Technol Aliment

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Background. Bioactive peptides derived from food proteins have been the subject of considerable interest in recent years. Therefore, the present study aimed to evaluate the nutraceutical properties (antioxidant, antihypertensive, and antidiabetic activities) of bioactive peptides encrypted in seed storage proteins of Moringa oleifera using in vitro gastrointestinal digestion. Materials and methods. Seeds were ground and sieved. Next, the flour was defatted, washed, and dried. Seed storage proteins were obtained from moreinga seed flour using different solvents. Total proteins were extracted with sodium borato, centrifuged, and precipitated. Finally, hydrolysates were obtained with pepsin, trypsin, and chymotrypsin. The hydrolysates were fractionated by ultrafiltration with 10 and 3 kDa membranes.Results. Based on the obtained results, total globulin hydrolysate possessed a high percentage of angiotensinconverting enzyme inhibition (79.51 ±6.89%) and α-amylase inhibition activity (61.19 ±2.93%). On the other hand, the fraction F < 3 kDa had good antioxidant activity (290.66 ±26.9 μM). Conclusion. This study suggests that total globulin hydrolysates and F < 3 kDa had excellent in vitro nutraceutical potential.

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Section: Assays Of Angiotensin-converting Enzymementioning

confidence: 74%

Characterization of seed storage protein of Moringa oleifera and analyses of their bioactive peptide’s nutraceutical properties

Peraza-Juan¹,

Espinoza-Sánchez²,

Lara-Reyes³

et al. 2022

Acta Sci Pol Technol Aliment

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“…Plants have been fundamental to human existence, providing essential resources like food, shelter, clothing, and medicine throughout history [12][13][14]. Many cultures revere plants as gifts fulfilling various human needs, particularly in less developed countries where approximately 80% of the population relies on traditional medicine for healthcare [15,16].…”

Section: Introductionmentioning

confidence: 99%

Exploring the Pharmacological Potential of Lithospermum officinale L.: A Review of Phytochemicals and Ethnomedicinal Uses

Barkizatova,

Turgumbayeva,

Zhakipbekov

et al. 2024

Molecules

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Exploring phytochemicals from ethnomedicinal plants for pharmacological applications is a promising research area. By studying ethnomedicine, researchers can identify plants used for centuries to treat ailments and investigate their phytochemicals. Consequently, phytochemicals can be isolated, characterized, and tested for pharmacological activities, leading to new drug development. This research also helps preserve traditional knowledge and biodiversity. Lithospermum officinale L., found in Eurasia, Argentina (South), Colombia, and the United States, is valued for its medicinal properties, including anti-inflammatory, antioxidant, and antimicrobial effects. The current review emphasizes L. officinale L. as a significant reservoir of bioactive phytochemicals, with alkaloids, quinones, glucosides, phenolics, flavonoids, and lipids identified as the principal metabolites. It also unveils the unexplored potential of this plant for future research endeavors. Continued research on L. officinale L. can unlock its full potential, providing insights into its medicinal uses and contributing to biodiversity preservation.

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“…In this context, products containing medicinal plant extracts have been proposed for the treatment of OM [13]. Several forms of treatment for OM have been proposed, considering the antiinflammatory and antimicrobial properties of drugs, since the breakdown of the mucosal barrier is the gateway to colonization by fungi such as Candida albicans and bacteria from the oral microbiome [14]. The use of natural products for the treatment of diseases that affect human beings was one of the first forms of medicine in the world [15].…”

Section: Introductionmentioning

confidence: 99%

Grade IV oral mucositis treatment with Brazilian green propolis mucoadherent gel

Silva,

Caldeira,

de Sousa

et al. 2023

Explor Drug Sci

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Green propolis is collected by Apis mellifera from the flowers and buds of Baccharis dracunculifolia. It has several chemical compounds that confer anti-inflammatory, antimicrobial, healing, and antioxidant biological activities. To report a series of clinical cases in the treatment of oral mucositis (OM) in patients with cancer undergoing radiotherapy in the head and neck region. Rapid treatment of OM means restoring quality of life to patients and lowering the cost of cancer treatment for public health. There male patients with oral carcinoma undergoing radiotherapy treatment were followed between August 2018 and April 2019. The patients presented themselves to the clinics in the Faculty of Dentistry of Federal University of Minas Gerais with erythematous and ulcerated coalescing lesions with purulent fibrin pseudomembranes in the oral mucosa, classified as grade IV OM according to the World Health Organization. The patients complained about the inability to eat, drink, and speak, which caused the radiotherapy interruption. After completing the clinical forms, anamnesis, and proper oral hygiene of each patient, a mucoadherent gel containing 5% propolis was prescribed for daily use, with a 3 time-a-day application every 8 h. After 7 days of use, there was an 80% lesion reduction, with total remission after 15 days of its application. The rapid response with total remission of lesions seems to be related to the chemical composition of propolis. Clinical and cellphone monitoring of patients, weekly and daily, respectively, were essential for successful treatment. The patients were monitored for one year, being encouraged to make constant use of the gel to control hyposalivation caused by changes in the salivary glands during radiotherapy.

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Biologia futura: medicinal plants-derived bioactive peptides in functional perspective—a review

Cited by 12 publications

References 96 publications

Characterization of seed storage protein of Moringa oleifera and analyses of their bioactive peptide’s nutraceutical properties

Characterization of seed storage protein of Moringa oleifera and analyses of their bioactive peptide’s nutraceutical properties

Exploring the Pharmacological Potential of Lithospermum officinale L.: A Review of Phytochemicals and Ethnomedicinal Uses

Grade IV oral mucositis treatment with Brazilian green propolis mucoadherent gel

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