Biologic agents in the management of inflammatory eye diseases

Michalova, Kyra

doi:10.1007/s11882-008-0054-2

Cited by 23 publications

(9 citation statements)

References 54 publications

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“…Tumor necrosis factor-α (TNF-α) is a commonly accepted key inflammatory factor [29]–[31]. The level of TNF-α was increased after alkali burn, which contribute to corneal inflammation.…”

Section: Discussionmentioning

confidence: 99%

Anti-Angiogenic and Anti-Inflammatory Effects of SERPINA3K on Corneal Injury

et al. 2011

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SERPINA3K is a member of the serine proteinase inhibitor (SERPIN) family. Here we evaluated the therapeutic effects of SERPINA3K on neovascularization and inflammation in a rat cornea alkali burn model that is commonly employed to study corneal wounding. Topical treatment of the injured rat cornea with SERPINA3K (20 µg/eye/day) for 7 days significantly decreased the neovascular area, compared with the groups treated with BSA or PBS. The SERPINA3K treatment also ameliorated the corneal inflammation as evaluated by the inflammatory index. Furthermore, SERPINA3K enhanced the recovery of corneal epithelium after the alkali injury. Toward the mechanism of action, SERPINA3K down-regulated the expression of the pro-angiogenic and pro-inflammatory factors, vascular endothelial growth factor and tumor necrosis factor-α and up-regulated the expression of the anti-angiogenic factor, pigment epithelium-derived factor. SERPINA3K specifically inhibited growth of vascular endothelial cells. Meanwhile, SERPINA3K significantly up-regulated the expression of EGFR in the corneal epithelium. These findings suggest that SERPINA3K has therapeutic potential for corneal inflammation and NV.

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Section: Discussionmentioning

confidence: 99%

Anti-Angiogenic and Anti-Inflammatory Effects of SERPINA3K on Corneal Injury

et al. 2011

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“…Contrary, proinflammatory and macrophage-attracting factors including MCP1, TNF α , and IFN- γ significantly increased as a result of UVB irradiation of limbal fibroblasts. TNF α is an important proinflammatory cytokine [ 151 ] which causes leukocyte recruitment, oedema, and vasodilatation thus leading to cornea neovascularisation [ 152 ]. IFN- γ is associated to neovascularisation induced by upregulation of macrophage-produced VEGF [ 92 , 153 ] while MCP1 acts by promoting angiogenesis [ 154 ] as well as a monocyte-attracting chemokine [ 155 ].…”

Section: Effects Of Uv Irradiation To the Limbal Niche: Pterygium mentioning

confidence: 99%

The Role of Limbal Epithelial Stem Cells in Regulating Corneal (Lymph)angiogenic Privilege and the Micromilieu of the Limbal Niche following UV Exposure

Notara

Lentzsch

Coroneo

et al. 2018

Stem Cells International

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The cornea is a clear structure, void of blood, and lymphatic vessels, functioning as our window to the world. Limbal epithelial stem cells, occupying the area between avascular cornea and vascularized conjunctiva, have been implicated in tissue border maintenance, preventing conjunctivalisation and propagation of blood and lymphatic vessels into the cornea. Defects in limbal epithelial stem cells are linked to corneal neovascularisation, including lymphangiogenesis, chronic inflammation, conjunctivalisation, epithelial abnormalities including the presence of goblet cells, breaks in Bowman's membrane, persistent epithelial defects and ulceration, ocular surface squamous neoplasia, lipid keratopathy, pain, discomfort, and compromised vision. It has been postulated that pterygium is an example of focal limbal deficiency. Previous reports showing changes occurring in limbal epithelium during pterygium pathogenesis suggest that there is a link to stem cell damage. In this light, pterygium can serve as a model disease of UV-induced stem cell damage also characterised by corneal blood and lymphangiogenesis. This review focuses on the role of corneal and limbal epithelial cells and the stem cell niche in maintaining corneal avascularity and corneal immune privilege and how this may be deregulated following UV exposure. We present an overview of the PUBMED literature in the field as well as recent work from our laboratories.

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“…1 Large amounts of TNF-α are released in response to lipopolysaccharide (LPS), other bacterial products, and interleukin-1 (IL-1) release by macrophages and retinal cells (including the retinal pigment epithelium). 2 The receptors TNFR-1 (or p55) and TNFR-2 (or p75) are the targets of TNF-α and mediate its biologic activity in cells and cell membranes. TNFR-1 may be involved in pro-apoptotic and inflammatory signaling pathways, whereas TNFR-2 may be involved in cell growth and proliferation.…”

mentioning

confidence: 99%

Adalimumab for Ocular Inflammation

Durrani

Kempen

Ying

et al. 2016

Ocular Immunology and Inflammation

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Purpose To evaluate adalimumab as an immunomodulatory treatment for non-infectious ocular inflammatory diseases. Methods Characteristics of patients treated with adalimumab were abstracted in a standardized chart review. Main outcomes measured were control of inflammation, corticosteroid-sparing effect, and visual acuity. Results In total, 32 patients with ocular inflammation were treated with adalimumab. The most common ophthalmic diagnoses were anterior uveitis, occurring in 15 patients (47%), and scleritis, occurring in 9 patients (28%). At 6 months of therapy, among 15 eyes with active inflammation, 7 (47%) became completely inactive, and oral prednisone was reduced to ≤10 mg/day in 2 of 4 patients (50%). On average, visual acuity decreased by 0.13 lines during the first 6 months of treatment. Adalimumab was discontinued because of lack of effectiveness in four patients within 6 months. Conclusions Adalimumab was moderately effective in controlling inflammation in a group of highly pre-treated cases of ocular inflammatory disease.

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Biologic agents in the management of inflammatory eye diseases

Cited by 23 publications

References 54 publications

Anti-Angiogenic and Anti-Inflammatory Effects of SERPINA3K on Corneal Injury

Anti-Angiogenic and Anti-Inflammatory Effects of SERPINA3K on Corneal Injury

The Role of Limbal Epithelial Stem Cells in Regulating Corneal (Lymph)angiogenic Privilege and the Micromilieu of the Limbal Niche following UV Exposure

Adalimumab for Ocular Inflammation

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