Biologic and molecular effects of granulocyte colony-stimulating factor in healthy individuals: recent findings and current challenges

Anderlini, Paolo; Champlin, Richard E.

doi:10.1182/blood-2007-07-097543

Cited by 156 publications

(150 citation statements)

References 64 publications

(59 reference statements)

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“…Most allogeneic donors are mobilized with 10 mcg/kg for 5 days [10][11][12][13][14]. Doses as high as 20 mcg/kg daily have been employed.…”

Section: Allogeneic Peripheral Blood Stem Cell Collectionmentioning

confidence: 99%

“…In addition to leukocytosis, filgrastim also causes a transient increase in serum alkaline phosphatase, transaminases, LDH levels [11].…”

Section: Allogeneic Peripheral Blood Stem Cell Collectionmentioning

confidence: 99%

“…This should ideally be established through the peripheral antecubital veins if they are large enough to accommodate a [16][17][18] [32]. Middle-age women seem to be at particular risk for this [11].…”

Section: Vascular Accessmentioning

confidence: 99%

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Allogeneic peripheral blood stem cell collection as of 2008

Rhodes

Anderlini

2008

Transfusion and Apheresis Science

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The rapid growth of the use of recombinant human granulocyte colony-stimulating factor (rhG-CSF) to mobilize and collect allogeneic peripheral blood stem cells (PBSCs) for transplantation has made it a new international standard. While the procedure remains safe, older donors, donors with significant comorbidities and pediatric donors are now often employed. This brings a new set of challenges in the donor evaluation, medical clearance, informed consent and collection process. Rare and unexpected severe adverse events related to rhG-CSF administration and PBSC apheresis have been described. Proper PBSC donor counseling, evaluation and care have become even more important.

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“…Most allogeneic donors are mobilized with 10 mcg/kg for 5 days [10][11][12][13][14]. Doses as high as 20 mcg/kg daily have been employed.…”

Section: Allogeneic Peripheral Blood Stem Cell Collectionmentioning

confidence: 99%

“…In addition to leukocytosis, filgrastim also causes a transient increase in serum alkaline phosphatase, transaminases, LDH levels [11].…”

Section: Allogeneic Peripheral Blood Stem Cell Collectionmentioning

confidence: 99%

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Allogeneic peripheral blood stem cell collection as of 2008

Rhodes

Anderlini

2008

Transfusion and Apheresis Science

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“…Indeed, during the first months of illness our patient's CRP never went below 150 mg/l and matched similar swings in ALP despite antibiotic treatment. We reasoned that G-CSF, a naturally occurring cytokine that increases proliferation and promotes the activity of myeloid cells through various biochemical effects might help with the chronic infection [3,4]. It should be said that on admission, the patient's neutrophil level was normal, and throughout the course of the illness never fell below range, in fact always increasing after G-CSF administration.…”

Section: Discussionmentioning

confidence: 99%

“…It should be said that on admission, the patient's neutrophil level was normal, and throughout the course of the illness never fell below range, in fact always increasing after G-CSF administration. After the two rounds of G-CSF treatment the CRP normalised whereas the ALP improvement was more erratic due to the transient G-CSF induced osteoclastic activity that could briefly increase bone-specific ALP [4].…”

Section: Discussionmentioning

confidence: 99%

Improvement of Chronic Osteomyelitis After Granulocyte Colony Stimulating Factor

Pearce

Cuthbert

Porter

2011

Indian J Hematol Blood Transfus

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Background: chronic osteomyelitis represents a persistent bone and bone marrow infection easy to diagnose in the presence of pain, erythema, swelling, and a draining sinus but more difficult to detect in the absence of the preceding features and with a painful orthopaedic prosthesis. Case Description: we report upon an elderly gentleman with myelodysplasia requiring revision surgery for a fractured prosthetic left knee. He had clinical, laboratory, and radiological features of chronic osteomyelitis that improved only with adminis-

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Influence of repeated subcutaneous G‐CSF injections on selected blood parameters relevant for monitoring programmes in sports drug testing

Walpurgis

Slijepcevic

Wenzel

et al. 2012

Drug Testing and Analysis

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The use of growth factors in sports is restricted under the terms of the World Anti-Doping Code (WADC). While the beneficial effects of erythropoietin (EPO) on erythropoiesis and therefore its performance-enhancing properties have been well documented and established for decades, the aim of this study was to elucidate the relevance of the cytokine G-CSF in a doping control context, particularly concerning its influence on selected blood parameters representing central aspects of the Athlete Biological Passport. For that purpose, the effect of repeated subcutaneous granulocyte colony-stimulating factor (G-CSF) injections in therapeutic dosages (10 µg/kg/d) on white blood cells, erythrocytes, hemoglobin, hematocrit and percent reticulocytes was analyzed by using commonly employed fluorescence flow cytometry-based approaches. A total of 20 people were tested (14 male, 6 female) and both white blood cell count and reticulocyte percentages were found to significantly increase following a 5-day treatment with G-CSF. Simultaneously, all other volume-dependent parameters (red blood cell count, hemoglobin, hematocrit) slightly but significantly decreased. Due to the relevance of these measurands for the validity of blood tests for doping controls and the anecdotal evidence of G-CSF being potentially misused by elite athletes, G-CSF analyses might be indicated in case of unusually altered blood profiles.

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Biologic and molecular effects of granulocyte colony-stimulating factor in healthy individuals: recent findings and current challenges

Cited by 156 publications

References 64 publications

Allogeneic peripheral blood stem cell collection as of 2008

Allogeneic peripheral blood stem cell collection as of 2008

Improvement of Chronic Osteomyelitis After Granulocyte Colony Stimulating Factor

Influence of repeated subcutaneous G‐CSF injections on selected blood parameters relevant for monitoring programmes in sports drug testing

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